DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm7 and MCM4

DIOPT Version :9

Sequence 1:	NP_523984.1	Gene:	Mcm7 / 39014	FlyBaseID:	FBgn0020633	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_015344.1	Gene:	MCM4 / 856130	SGDID:	S000006223	Length:	933	Species:	Saccharomyces cerevisiae

Alignment Length:	755	Identity:	253/755 - (33%)
Similarity:	378/755 - (50%)	Gaps:	111/755 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RESIKTFLSEFCKCDDDGKKEFVYGSQLVKLAHREQVLITIDLDDLAEFNESLAEAVVDNCRRYT 74
            |..:.:|..:|.|..|: ::||:..:...:|.:.:|      |:::.|...|..
Yeast   195 RNFLMSFKYKFRKILDE-REEFINNTTDEELYYIKQ------LNEMRELGTSNL----------- 241

  Fly    75 SIFSDVIAELLPSYKQQEVHAKDALDVYIEHRLM---------MESRTRNPMEQRDERNSFPSEL 130
                ::.|..|.:|||.|       |:|  |:|:         |:...::.|......|:...:|
Yeast   242 ----NLDARNLLAYKQTE-------DLY--HQLLNYPQEVISIMDQTIKDCMVSLIVDNNLDYDL 293

  Fly   131 ----MKRFEVGFKPLSTEKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRCGSET 191
                .|.::|  :|.:......:||:....|.||:.::|:|.|.|.|.|.|.||.:.|:.|....
Yeast   294 DEIETKFYKV--RPYNVGSCKGMRELNPNDIDKLINLKGLVLRSTPVIPDMKVAFFKCNVCDHTM 356

  Fly   192 YQPVNSLSFTPVHDCPSDDCRVNKAGGRLYLQTRGSKFVKFQEVKMQEHSDQVPVGHIPRSMTIM 256
            ...::.........|...||  |:......:..|.| |...|.:|:||..|.||.|..|.|:::.
Yeast   357 AVEIDRGVIQEPARCERIDC--NEPNSMSLIHNRCS-FADKQVIKLQETPDFVPDGQTPHSISLC 418

  Fly   257 CRGEVTRMAQPGDHIVVSGVF--LPLMRTGFAQMIQGLLSETFLQAHRIICINK-NDEISDKDAE 318
            ...|:....:.||.|.|:|.|  :|: |....|.:...|.:|::.   ::.:.| :|:..|.|..
Yeast   419 VYDELVDSCRAGDRIEVTGTFRSIPI-RANSRQRVLKSLYKTYVD---VVHVKKVSDKRLDVDTS 479

  Fly   319 LTPEEL-------------------------EELAQDDFYERLATSLAPEIYGHLDVKKALLLLL 358
            ...:||                         |..|::|.|..||.|:||.||...||||.:||.|
Yeast   480 TIEQELMQNKVDHNEVEEVRQITDQDLAKIREVAAREDLYSLLARSIAPSIYELEDVKKGILLQL 544

  Fly   359 VGGVDKR-PDGMKIRGNINICLMGDPGVAKSQLLGYISRLAVRSQYTTGRGSSGVGLTAAVMKDP 422
            .||.:|. ..|.:.||:|||.|.|||..:|||:|.|:.::..|..||:|:|||.|||||.:.:|.
Yeast   545 FGGTNKTFTKGGRYRGDINILLCGDPSTSKSQILQYVHKITPRGVYTSGKGSSAVGLTAYITRDV 609

  Fly   423 LTGEMTLEGGALVLADQGVCCIDEFDKMADQDRTAIHEVMEQQTISIAKAGIMTTLNARVSILAA 487
            .|.::.||.|||||:|.|||||||||||:|..|:.:||||||||||||||||:||||||.||||:
Yeast   610 DTKQLVLESGALVLSDGGVCCIDEFDKMSDSTRSVLHEVMEQQTISIAKAGIITTLNARSSILAS 674

  Fly   488 ANPAFGRYNPRRTVEQNIQLPAALLSRFDLLWLIQDKPDRDNDLRLAKHITYVHSHSKQPPTRVK 552
            |||...||||...|.:||.||..|||||||::|:.||.|..||..||||:|.::...|  |..:.
Yeast   675 ANPIGSRYNPNLPVTENIDLPPPLLSRFDLVYLVLDKVDEKNDRELAKHLTNLYLEDK--PEHIS 737

  Fly   553 ---ALDMNLMRRYINLCKRK-NPTIPDELTDYIVGAYVELRR---EARNQKDMTFTSARNLLGIL 610
               .|.:..:..||:..|.. :|.|.:.....:|.|||.:|:   ::|:.:.....:.|.|..::
Yeast   738 QDDVLPVEFLTMYISYAKEHIHPIITEAAKTELVRAYVGMRKMGDDSRSDEKRITATTRQLESMI 802

  Fly   611 RLSTALARLRLSDSVEKDDVAEALRLLEMS-KDSLNQIHEHQKGHVPNTSDRIFAIVRELAGSGK 674
            ||:.|.|:::|.:.||.:||.||:||:..: ||....         |.|.    .|...|..:||
Yeast   803 RLAEAHAKMKLKNVVELEDVQEAVRLIRSAIKDYATD---------PKTG----KIDMNLVQTGK 854

  Fly   675 AV---KISDIMDRCTTKGFKPDQVDKCIDDYEELNVWQVN 711
            :|   |:.:.:.|......|....|..  .:.|| :.|:|
Yeast   855 SVIQRKLQEDLSREIMNVLKDQASDSM--SFNEL-IKQIN 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm7	NP_523984.1	MCM_N	13..97	CDD:379644	17/83 (20%)
Mcm7	NP_523984.1	MCM	145..641	CDD:214631	207/532 (39%)
MCM4	NP_015344.1	MCM_N	194..306	CDD:405270	28/143 (20%)
MCM4	NP_015344.1	MCM	310..834	CDD:214631	207/532 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810