DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm7 and MCM8

DIOPT Version :9

Sequence 1:	NP_523984.1	Gene:	Mcm7 / 39014	FlyBaseID:	FBgn0020633	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_001268450.1	Gene:	MCM8 / 84515	HGNCID:	16147	Length:	880	Species:	Homo sapiens

Alignment Length:	773	Identity:	209/773 - (27%)
Similarity:	331/773 - (42%)	Gaps:	204/773 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 ITIDLDDLAEFNESLAEAVVDNCRRYTSIFSDVIAELLPSYKQQEVHAKDALDVYIE------HR 106
            |.:|..:|.|..|            .|::..|:..||           :||.:..:.      |:
Human   121 ILVDFKELTEGGE------------VTNLIPDIATEL-----------RDAPEKTLACMGLAIHQ 162

  Fly   107 LMMESRTRNPME-QRDERNSFPSELMKRFE------VGFKPLSTEKAHSIREVKAQHIGKLVTVR 164
            ::.:...|:..| |..|..|...|.|....      ..::||:     .::.|:|.:.||.:.:|
Human   163 VLTKDLERHAAELQAQEGLSNDGETMVNVPHIHARVYNYEPLT-----QLKNVRANYYGKYIALR 222

  Fly   165 GIVTRCTEVKPMMVVATYTCDRCGSETYQPVNSLSFTPVHDCPSDDCRVNKAGGRLYLQTRGSKF 229
            |.|.|.:.:||:.....:.|..||.....|:....::....||...||     ||.:...|.|..
Human   223 GTVVRVSNIKPLCTKMAFLCAACGEIQSFPLPDGKYSLPTKCPVPVCR-----GRSFTALRSSPL 282

  Fly   230 ---VKFQEVKMQE--HSDQVPVGHIPRSMTIMCR--GEVTRMAQPGDHIVVSGVFLPLMRTGFAQ 287
               :.:|.:|:||  ..||...|.|||  ||.|.  .::.....|||.:.::|:    ::...|:
Human   283 TVTMDWQSIKIQELMSDDQREAGRIPR--TIECELVHDLVDSCVPGDTVTITGI----VKVSNAE 341

  Fly   288 MIQGLLSETFLQAHRIICINKNDE-----------ISDKDAELTPEE--------LEELAQDDFY 333
                       :..|    ||||:           ||:...:.|...        |.|.:..|.|
Human   342 -----------EGSR----NKNDKCMFLLYIEANSISNSKGQKTKSSEDGCKHGMLMEFSLKDLY 391

  Fly   334 --------ERL-------ATSLAPEI-YG---------HLD------------------------ 349
                    |.|       :.:|:|.: |.         ||.
Human   392 AIQEIQAEENLFKLIVKWSLALSPRLEYSGAISAHCNLHLPSSNSSPTSACRVAGTTGMRHQTQL 456

  Fly   350 ---VKKALLLLLVGGVDKRPDG---MKIRGNINICLMGDPGVAKSQLLGYISRLAVRSQYTTGRG 408
               ||..|.|.|.||..|..|.   :.|||:.:|.::||||:.|||:|.....:|.|..|..|..
Human   457 LLLVKAGLALALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNT 521

  Fly   409 SSGVGLTAAVMKDPLTGEMTLEGGALVLADQGVCCIDEFDKMADQDRTAIHEVMEQQTISIAKAG 473
            ::..|||..:.||..:|:..||.|||||.|||:|.|||||||.:|.: |:.|.||||:||:||||
Human   522 TTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAG 585

  Fly   474 IMTTLNARVSILAAANPAFGRYNPRRTVEQNIQLPAALLSRFDLLWLIQDKPDRDNDLRLAKHIT 538
            ::.:|.||.||:|||||..|.||..:||.:|:::.:||||||||::::.|.|:..:|..|::|:.
Human   586 VVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVI 650

  Fly   539 YVHSH-----SKQPPTRVKALDMN------------------------------LMRRYINLCKR 568
            .:.:.     |.....|:.:.|.|                              |:|:||...::
Human   651 AIRAGKQRTISSATVARMNSQDSNTSVLEVVSEKPLSERLKVVPGETIDPIPHQLLRKYIGYARQ 715

  Fly   569 -KNPTIPDELTDYIVGAYVELRREARNQKDMTFTSARNLLGILRLSTALARLRLSDSVEKDDVAE 632
             ..|.:..|....:...|:|||::::.......|: |.|..::||:.|.|||.|.:...|:|..:
Human   716 YVYPRLSTEAARVLQDFYLELRKQSQRLNSSPITT-RQLESLIRLTEARARLELREEATKEDAED 779

  Fly   633 ALRLLEMSKDSLNQIHEHQKGHVPNTSDRIFAIVRELAGSGKAVKISDIMDRCTTKGF 690
               ::|:.|.|:...:..:.|::.        ..|...|||       :.:|.|.|.|
Human   780 ---IVEIMKYSMLGTYSDEFGNLD--------FERSQHGSG-------MSNRSTAKRF 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm7	NP_523984.1	MCM_N	13..97	CDD:379644	9/48 (19%)
Mcm7	NP_523984.1	MCM	145..641	CDD:214631	177/612 (29%)
MCM8	NP_001268450.1	MCM_N	98..223	CDD:291233	25/129 (19%)
		Mcm2	139..877	CDD:224162	203/743 (27%)
		AAA	475..633	CDD:99707	78/158 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820