DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm7 and MCM8

DIOPT Version :9

Sequence 1:	NP_523984.1	Gene:	Mcm7 / 39014	FlyBaseID:	FBgn0020633	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_001319512.1	Gene:	MCM8 / 820123	AraportID:	AT3G09660	Length:	801	Species:	Arabidopsis thaliana

Alignment Length:	613	Identity:	190/613 - (30%)
Similarity:	303/613 - (49%)	Gaps:	108/613 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 ERNSFPSELMKRFEVGFKPLSTEKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDR 186
            |.|.|.:.:.....:...|   |.:.|::.::|.:|||||||.|.|.:.:.|||::....:.|.:
plant   121 ETNEFENVMKINVRLHNYP---ESSISLKNLRAAYIGKLVTVHGTVVKVSTVKPLVTQMAFDCGK 182

  Fly   187 CGSETYQPVNSLSFTPVHDCPSDDCRVNKAGGRLYLQTRGS-KFVKFQEVKMQE------HSDQV 244
            |.:...:......|:|...|.|..|:     .:.:...|.| :.:.||::::||      |.:
plant   183 CKTGITREFTDGKFSPPLKCDSHGCK-----SKTFTPIRSSAQTIDFQKIRVQELQKPEDHEE-- 240

  Fly   245 PVGHIPRSMTIMCRGEVTRMAQPGDHIVVSGVFLPLMRTGFAQM---IQGLLSETFLQAHRIICI 306
              |.:||::......::..:..|||.:.|:|:.      |....   |.|..|:|..|....:.|
plant   241 --GRVPRTVECELMEDLVDICIPGDVVTVTGII------GVINNYMDIGGGKSKTKNQGFYYLFI 297

  Fly   307 ---------------NKND--------------EISDKDAELTPEELEELAQDDFYERLATSLAP 342
                           |..|              ..|.:|.|...:..||...|.| .|:..|:.|
plant   298 EAVSVKNTKRQSAFENSEDSSSSAQTADVGDLYSFSQRDLEFIVKFKEEYGSDTF-RRILHSVCP 361

  Fly   343 EIYGHLDVKKALLLLLVGGVDKRP---DGMKIRGNINICLMGDPGVAKSQLLGYISRLAVRSQYT 404
            .||||..||..:.|.|.|||.|..   :.:.:||:|::.::||||:.|||||...:.::.|..|.
plant   362 SIYGHEIVKAGITLSLFGGVRKHSMDRNKVPVRGDIHVIIVGDPGLGKSQLLQAAAAISPRGIYV 426

  Fly   405 TGRGSSGVGLTAAVMKDPLTGEMTLEGGALVLADQGVCCIDEFDKMADQDRTAIHEVMEQQTISI 469
            .|..::..|||.||:||.:|.:...|.||:||||.|:|||||||||..:.: |:.|.||||.:|:
plant   427 CGNATTRAGLTVAVVKDSMTNDYAFEAGAMVLADGGLCCIDEFDKMTTEHQ-ALLEAMEQQCVSV 490

  Fly   470 AKAGIMTTLNARVSILAAANPAFGRYNPRRTVEQNIQLPAALLSRFDLLWLIQDKPDRDNDLRLA 534
            ||||::.:|:||.|::|||||..|.||..:||.:|:::.|||||||||::::.||||...|.:::
plant   491 AKAGLVASLSARTSVIAAANPVGGHYNRAKTVNENLKMSAALLSRFDLVFILLDKPDELLDKQVS 555

  Fly   535 KHITYVHSHSKQPPTRVK------ALDMN---------------------------------LMR 560
            :||..:||.|.:....:|      |...|                                 |:|
plant   556 EHIMSLHSASGETSPALKKFKPVNAASQNAGYANMHAEGNSLLSRLRLDSEKDDDFSPVPGQLLR 620

  Fly   561 RYINLCKR-KNPTIPDELTDYIVGAYVELRREARNQKDMTFTSARNLLGILRLSTALARLRLSDS 624
            :||:..:. .||.:..:..:.|...|::| |:.....|.|..:||.|..::||:.|.||:.|.:.
plant   621 KYISYARNFVNPKMSKDAGEIIQKFYLKL-RDHNTSADSTPITARQLESLVRLAQARARVDLREE 684

  Fly   625 VEKDDVAEALRLLEMSKDSL--NQIHEH 650
            :   .|.:|:.::|:.|:||  ..|.||
plant   685 I---TVQDAMDVVEIMKESLYDKLIDEH 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm7	NP_523984.1	MCM_N	13..97	CDD:379644
Mcm7	NP_523984.1	MCM	145..641	CDD:214631	179/577 (31%)
MCM8	NP_001319512.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266497at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820