DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm7 and mcm8

DIOPT Version :9

Sequence 1:	NP_523984.1	Gene:	Mcm7 / 39014	FlyBaseID:	FBgn0020633	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_001072344.1	Gene:	mcm8 / 779797	XenbaseID:	XB-GENE-961372	Length:	843	Species:	Xenopus tropicalis

Alignment Length:	739	Identity:	209/739 - (28%)
Similarity:	353/739 - (47%)	Gaps:	148/739 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 FNESLAEA--VVDNCRRYTSIFSDVIAELLPSYKQQEVHAKDALD----VYIEHRLMMESRTRN- 115
            |:|:.:::  .::..|.:...|:          ||.|::.||.::    :.::::.:::....:
Frog    74 FSEAYSDSSPFLEKVRAFEKFFT----------KQIELYDKDEIERKGSILVDYKDLLQDEDLSA 128

  Fly   116 --PMEQRDERNSFPSELMKRFEVGF------------------KPLSTEKA--------HS---- 148
              ||.  .|....|.::::...:..                  :.|.||:|        |:
Frog   129 SIPMS--SELKEMPEKILECMGLAIHQVLTKDLERHAAELQEQEGLRTEEAPIVNVPFIHARVFN 191

  Fly   149 ------IREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRCGSETYQPVNSLSFTPVHDCP 207
                  ::.::|...||.|.:||.|.|.:.:||:.|...::|:.||.....|.....:.....||
Frog   192 YDPLTPLKNLRASLYGKYVALRGTVVRVSNIKPLCVKMAFSCNMCGDIQSFPFPDGKYAVPTKCP 256

  Fly   208 SDDCRVNKAGGRLYLQTRGSKF---VKFQEVKMQE--HSDQVPVGHIPRSMTIMCRGEVTRMAQP 267
            ..:||     ||.:...|.|..   |.:|.:|:||  ..||...|.|||::......::.....|
Frog   257 VPECR-----GRSFTANRSSPLTVTVDWQTIKVQELMSDDQREAGRIPRTVECELIQDLVDSCVP 316

  Fly   268 GDHIVVSGVFLPLMRT---GFAQMIQGLLSETFLQA--------HRIICINKNDEISDKDAELTP 321
            ||.:.|:|: :.:..|   ||.......:...:::|        |:|    |:.:.|:.......
Frog   317 GDMVTVTGI-VKVSNTRDGGFKNKNNKCMFLLYIEANSVSNSKGHKI----KSTDDSESHGASMD 376

  Fly   322 EELEEL-------AQDDFYERLATSLAPEIYGHLDVKKALLLLLVGGVDKRPDG---MKIRGNIN 376
            ..|::|       ||::.::.:..||.|.||||..||..|.|.|.||..|..|.   :.|||:.:
Frog   377 FSLKDLYAIQEIQAQENLFQLIVNSLCPTIYGHELVKAGLSLALFGGCQKYADDKNRIPIRGDPH 441

  Fly   377 ICLMGDPGVAKSQLLGYISRLAVRSQYTTGRGSSGVGLTAAVMKDPLTGEMTLEGGALVLADQGV 441
            |.::||||:.|||:|..:..:|.|..|..|..::..|||..:.:|..||:..||.|||:|.|||:
Frog   442 ILVVGDPGLGKSQMLQAVCNVAPRGVYVCGNTTTTSGLTVTLSRDSATGDFGLEAGALILGDQGI 506

  Fly   442 CCIDEFDKMADQDRTAIHEVMEQQTISIAKAGIMTTLNARVSILAAANPAFGRYNPRRTVEQNIQ 506
            |.|||||||.:|.: |:.|.||||:||:|||||:.:|.||.||:|||||..|.||..:||.:|::
Frog   507 CGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGIVCSLPARTSIIAAANPVGGHYNKGKTVSENLK 570

  Fly   507 LPAALLSRFDLLWLIQDKPDRDNDLRLAKHITYVHSHSKQ--------PPT-------------- 549
            :.:||||||||::::.|.|:.|:|..|::|:..:.:.:|:        |.|
Frog   571 MGSALLSRFDLVFILLDTPNEDHDHLLSEHVMAMRAGAKEMQSADLTCPTTQNSNTSVLEEPSER 635

  Fly   550 ----RVK--------ALDMNLMRRYINLCKR-KNPTIPDELTDYIVGAYVELRREARNQK-DMTF 600
                |:|        .:...|:|:|:...:: .:||:..:....:...|:|||::  ||. |.|.
Frog   636 PLGERLKLRPGEHFDPIPHQLLRKYVGYARQYVHPTLSPDAAQVLQDFYLELRKQ--NQGIDSTP 698

  Fly   601 TSARNLLGILRLSTALARLRLSDSVEKDDVAEALRLLEMS-----KDSLNQIHEHQKGHVPNTSD 660
            .:.|.|..::||:.|.|||.|.:...|||..|.:::::.|     .|...::..|:..|....|:
Frog   699 ITTRQLESLIRLTEARARLELREKATKDDAEEVVQIMKYSLLGTFSDEFGKLDFHRSQHGSGMSN 763

  Fly   661 RIFAIVRELAGSGKAVKISDIMDR 684
            |           .||.|....::|
Frog   764 R-----------SKAKKFISALNR 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm7	NP_523984.1	MCM_N	13..97	CDD:379644	7/40 (18%)
Mcm7	NP_523984.1	MCM	145..641	CDD:214631	184/580 (32%)
mcm8	NP_001072344.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52
		Mcm2	93..769	CDD:224162	204/711 (29%)
		MCM8	397..738	CDD:350665	130/343 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920