DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm7 and Mcm8

DIOPT Version :9

Sequence 1:	NP_523984.1	Gene:	Mcm7 / 39014	FlyBaseID:	FBgn0020633	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_001277983.1	Gene:	Mcm8 / 66634	MGIID:	1913884	Length:	833	Species:	Mus musculus

Alignment Length:	731	Identity:	215/731 - (29%)
Similarity:	339/731 - (46%)	Gaps:	148/731 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 IDLDDLAEFNESLAEAVVDNCRRYTSIFSDVIAELLPSYKQQEVHAKDALDVYIE------HRLM 108
            |||.|..|. |.....:|| .:..|.  :|.|..|:|..   |...:||.:..:.      |:::
Mouse   100 IDLYDKDEI-ERKGSILVD-FKELTK--ADEITNLIPDI---ENALRDAPEKTLACMGLAIHQVL 157

  Fly   109 MESRTRNPME-QRDERNSFPSELMKRFE------VGFKPLSTEKAHSIREVKAQHIGKLVTVRGI 166
            .:...|:..| |..|..|...|.|....      ..::||:     .::.::|...||.:::||.
Mouse   158 TKDLERHAAELQAQEGLSNGGETMVNVPHIYARVYNYEPLT-----HLKNIRATCYGKYISIRGT 217

  Fly   167 VTRCTEVKPMMVVATYTCDRCGSETYQPVNSLSFTPVHDCPSDDCRVNKAGGRLYLQTRGSKF-- 229
            |.|.:.:||:.....:.|..||.....|:....:|....||...||     ||.:...|.|..
Mouse   218 VVRVSNIKPLCTNMAFQCAACGEIQSFPLPDGKYTLPTKCPVPACR-----GRSFAPLRSSPLTV 277

  Fly   230 -VKFQEVKMQE-HSD-QVPVGHIPRSMTIMCR--GEVTRMAQPGDHIVVSGVFLPLMRTGFAQMI 289
             :.:|.:|:|| .|| |...|.|||  ||.|.  .::.....|||.:.|:|:            :
Mouse   278 TLDWQLIKIQELMSDAQREAGRIPR--TIECELVHDLVDSCVPGDTVTVTGI------------V 328

  Fly   290 QGLLSETFLQAHRIICINKNDE-----------ISD-------------KDAELTPEELEEL--- 327
            :...||   :..|    ||||:           :|:             |...|....|::|
Mouse   329 KVSNSE---EGSR----NKNDKCMFLLYIEANSVSNSKGPKAQTAEDGCKHGTLMEFSLKDLYAI 386

  Fly   328 ----AQDDFYERLATSLAPEIYGHLDVKKALLLLLVGGVDKRPDG---MKIRGNINICLMGDPGV 385
                |:::..:.:..||.|.|:||..||..|.|.|.||..|..|.   :.|||:.::.::||||:
Mouse   387 REIQAEENLLKLVVNSLCPVIFGHELVKAGLTLALFGGSQKYADDKNRIPIRGDPHVLIVGDPGL 451

  Fly   386 AKSQLLGYISRLAVRSQYTTGRGSSGVGLTAAVMKDPLTGEMTLEGGALVLADQGVCCIDEFDKM 450
            .|||:|.....:|.|..|..|..::..|||..:.||..:|:..||.|||||.|||:|.|||||||
Mouse   452 GKSQMLQAACNVAPRGVYVCGNTTTSSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKM 516

  Fly   451 ADQDRTAIHEVMEQQTISIAKAGIMTTLNARVSILAAANPAFGRYNPRRTVEQNIQLPAALLSRF 515
            .:|.: |:.|.||||:||:||||::.:|.||.||:|||||..|.||..|||.:|:::.:||||||
Mouse   517 GNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKARTVSENLKMGSALLSRF 580

  Fly   516 DLLWLIQDKPDRDNDLRLAKHITYVHSH-----SKQPPTRVKALDMN------------------ 557
            ||::::.|.|:..:|..|::|:..:.:.     |....|||.:.|.|
Mouse   581 DLVFILLDTPNEQHDHLLSEHVIAIRAGKQKAVSSATVTRVLSQDSNTSVLEVVSEKPLSERLKV 645

  Fly   558 ------------LMRRYINLCKR-KNPTIPDELTDYIVGAYVELRREARNQKDMTFTSARNLLGI 609
                        |:|:||...:: .:|.:..:....:...|:|||::::.......|: |.|..:
Mouse   646 APGEQTDPIPHQLLRKYIGYARQYVHPRLSTDAAQALQDFYLELRKQSQRVGSSPITT-RQLESL 709

  Fly   610 LRLSTALARLRLSDSVEKDDVAEALRLLEMSKDSLNQIHEHQKGHVPNTSDRIFAIVRELAGSGK 674
            :||:.|.|||.|.:...::|..:   ::|:.|.|:...:..:.|::.        ..|...|||
Mouse   710 IRLTEARARLELREEATREDAED---IIEIMKHSMLGTYSDEFGNLD--------FERSQHGSG- 762

  Fly   675 AVKISDIMDRCTTKGF 690
                  :.:|.|.|.|
Mouse   763 ------MSNRSTAKRF 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm7	NP_523984.1	MCM_N	13..97	CDD:379644	14/46 (30%)
Mcm7	NP_523984.1	MCM	145..641	CDD:214631	178/572 (31%)
Mcm8	NP_001277983.1	MCM_N	91..216	CDD:291233	29/127 (23%)
		Mcm2	132..830	CDD:224162	203/695 (29%)
		AAA	428..586	CDD:99707	78/158 (49%)
		PEPcase	<676..>747	CDD:304407	18/74 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820