DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm7 and mcm6

DIOPT Version :9

Sequence 1:	NP_523984.1	Gene:	Mcm7 / 39014	FlyBaseID:	FBgn0020633	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_001076318.1	Gene:	mcm6 / 566409	ZFINID:	ZDB-GENE-030909-6	Length:	830	Species:	Danio rerio

Alignment Length:	712	Identity:	240/712 - (33%)
Similarity:	354/712 - (49%)	Gaps:	121/712 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KTFLSEFCKCDDDGKKEFVYGSQLVKLAHREQVLITIDLDDLAEFNESLAEAVVDNCRRYTSIFS 78
            :.||.||  .:.||:.:::..::  :|...|:..:.:...||..||:.||.|:
Zfish    29 QAFLEEF--QNSDGEVKYLRDAE--ELIRPERNTLAVSFTDLEGFNQELATAI------------ 77

  Fly    79 DVIAELLPSYKQQEVHAKDALDVYIEHRLMMESRTRNPMEQRDERNSFPSELMKRFEVGFKPLST 143
                       |:|.:   .|..|:...:...:|         |....|:.  |.|.|.|:.|.|
Zfish    78 -----------QEEFY---RLYPYLCRAVRNFAR---------EHGEVPTS--KEFYVAFQDLPT 117

  Fly   144 EKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRCGSETYQPVNSLSFTPVHDCPS 208
            .  |.|||:....:|.||.:.|.|.|...|.|.:|..|:.|..|............:|....|.:
Zfish   118 R--HKIRELTTVKVGSLVRISGQVVRTHPVHPELVSGTFLCLDCQGVIKDVEQQFKYTQPSICRN 180

  Fly   209 DDCRVNKAGGRLYLQTRGSKFVKFQEVKMQEHSDQVPVGHIPRSMTIMCRGEVTRMAQPGDH--- 270
            ..|...:   |..|.|..|||:.||::::||...::|.|.|||||.::.|.|....||.||.
Zfish   181 PVCNNRR---RFLLDTNKSKFIDFQKLRIQETQAELPRGSIPRSMEVILRAEAVESAQAGDKCDF 242

  Fly   271 ----IVV---SGVFLPLMRTGFAQM---IQGLLSE-----------------TFLQAHRIICINK 308
                |||   |.:..|.:|...:..   :||..:|                 .||..|   ....
Zfish   243 IGSLIVVPDISQLATPGVRAETSSRTAGVQGYENEGLRGLKALGVRELSYKLAFLACH---VAPT 304

  Fly   309 NDEISDK---DAELTPEELE------------ELAQD-DFYERLATSLAPEIYGHLDVKKALLLL 357
            |.....|   |.|.|.|.::            |::|| :.|..|.|||.|.|:|:.:||:.:||:
Zfish   305 NPRFGGKEIRDEEQTAESIKKQMSVQEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGILLM 369

  Fly   358 LVGGVDKRP-DGMKIRGNINICLMGDPGVAKSQLLGYISRLAVRSQYTTGRGSSGVGLTAAVMKD 421
            |.|||.|.. :|..:||:||:|::|||..||||.|.::.....|:.||:|:.||..||||||::|
Zfish   370 LFGGVPKTTMEGTSLRGDINVCVVGDPSTAKSQFLKHVEEFCPRAVYTSGKASSAAGLTAAVVRD 434

  Fly   422 PLTGEMTLEGGALVLADQGVCCIDEFDKMADQDRTAIHEVMEQQTISIAKAGIMTTLNARVSILA 486
            ..:.|..:|.|||:|||.|||||||||||..:|:.||||.||||||||.|||:..|||||.||||
Zfish   435 EESHEFVIEAGALMLADNGVCCIDEFDKMETRDQVAIHEAMEQQTISITKAGVKATLNARTSILA 499

  Fly   487 AANPAFGRYNPRRTVEQNIQLPAALLSRFDLLWLIQDKPDRDNDLRLAKHITYVHSHSKQPPTRV 551
            ||||..|||:..::::||:.|.|.::|||||.:::.|..:...|..:|:.|..:||..:....||
Zfish   500 AANPVSGRYDRSKSLKQNVNLTAPIMSRFDLFFILVDDCNEVTDYAIARRIVDLHSRIENSVDRV 564

  Fly   552 KALDMNLMRRYINLCKRKNPTIPDELTDYIVGAYVELRREARNQKDMTFT----SARNLLGILRL 612
            .:||.  :|||:...::..|.|..|..::||..|..||:  |:...:|.:    :.|.|..::||
Zfish   565 YSLDE--IRRYLLFARQFKPKISKESEEFIVEQYKRLRQ--RDGSGVTKSAWRITVRQLESLIRL 625

  Fly   613 STALARLRLSDSVEKDDVAEALRLLEMS---------------KDSLNQIHEHQ-KGH-VPN 657
            |.::||:...|.|:...|.||.|||..|               ::::.:..::| .|| |||
Zfish   626 SESMARMHCCDEVQPKHVKEAFRLLNKSIIRVETPDVNLDQEEEEAMEEEEDNQMNGHDVPN 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm7	NP_523984.1	MCM_N	13..97	CDD:379644	17/82 (21%)
Mcm7	NP_523984.1	MCM	145..641	CDD:214631	206/561 (37%)
mcm6	NP_001076318.1	MCM_N	27..137	CDD:291233	35/150 (23%)
		MCM	117..655	CDD:214631	207/549 (38%)
		P-loop_NTPase	<445..532	CDD:304359	58/86 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820