DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm7 and mcm6

DIOPT Version :9

Sequence 1:	NP_523984.1	Gene:	Mcm7 / 39014	FlyBaseID:	FBgn0020633	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_001016221.1	Gene:	mcm6 / 548975	XenbaseID:	XB-GENE-5870537	Length:	821	Species:	Xenopus tropicalis

Alignment Length:	679	Identity:	229/679 - (33%)
Similarity:	343/679 - (50%)	Gaps:	103/679 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KTFLS--EFCKCDDDGKKEFVYGSQLVKLAHREQVLITIDLDDLAEFNESLAEAVVDNCRRYTSI 76
            |.||.  |.||..|...   :|.|...:|...|:..:.::..|:..:|:.||..:
Frog    29 KLFLEFLEECKGKDGSN---LYVSAAEELVRPERNTLVVNFTDIEYYNQQLATTI---------- 80

  Fly    77 FSDVIAELLPSYKQQEVHAKDALDVYIEHRLMMESRTRNPMEQRDERNSFPSELMKRFEVGFKPL 141
                         |:|.:.     ||......:.|..|       :..:.|:.  |.|.|.|...
Frog    81 -------------QEEYYR-----VYPHLCRAVRSFAR-------QMGNIPAN--KEFYVAFSDF 118

  Fly   142 STEKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRCGSETYQPVNSLSFTPVHDC 206
            ...:  .|||:.:..||.|:.:.|.|.|...|.|.:|..|:.|..|.|..........:|....|
Frog   119 PARQ--KIRELSSAKIGTLLRISGQVVRTHPVHPELVSGTFLCMDCQSVVKDVEQQFRYTQPTIC 181

  Fly   207 PSDDCRVNKAGGRLYLQTRGSKFVKFQEVKMQEHSDQVPVGHIPRSMTIMCRGEVTRMAQPGDHI 271
            .:..|...:   |..|.|..|:||.||:|::||...::|.|.||||:.|:.|.|....|..||..
Frog   182 KNPVCANRR---RFTLDTNKSRFVDFQKVRIQETQAELPRGAIPRSVEIILRAEAVETAMAGDRC 243

  Fly   272 VVSGVFLPL------------MRTGF---------AQMIQGL-------LSE--TFLQAHRIICI 306
            ..:|..:.:            |.||.         ::.:|||       ||.  .||..| :...
Frog   244 DFTGTLIVVPDISALAAGDARMETGAKVTGGEGFNSEGVQGLKALGVRDLSYRLAFLACH-VGAT 307

  Fly   307 N-----KNDEISDKDAE-----LTPEELE---ELAQD-DFYERLATSLAPEIYGHLDVKKALLLL 357
            |     |:....|:.||     :|.:|.|   |::|| :.|..|.|||.|.|:|:.::|:.:||:
Frog   308 NPRFGGKDLREEDQTAESIKNQMTVQEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEIKRGVLLM 372

  Fly   358 LVGGVDKRP-DGMKIRGNINICLMGDPGVAKSQLLGYISRLAVRSQYTTGRGSSGVGLTAAVMKD 421
            |.|||.|.. :|..:||:||:|::|||..:|||.|.::...:.|:.||:|:.||..||||||:||
Frog   373 LFGGVPKTTMEGTSLRGDINVCIVGDPSTSKSQFLKHVEEFSPRAVYTSGKASSAAGLTAAVVKD 437

  Fly   422 PLTGEMTLEGGALVLADQGVCCIDEFDKMADQDRTAIHEVMEQQTISIAKAGIMTTLNARVSILA 486
            ..:.|..:|.|||:|||.|||||||||||..:|:.||||.||||||||.|||:..|||||.||||
Frog   438 EESHEFVIEAGALMLADNGVCCIDEFDKMDLKDQVAIHEAMEQQTISITKAGVKATLNARTSILA 502

  Fly   487 AANPAFGRYNPRRTVEQNIQLPAALLSRFDLLWLIQDKPDRDNDLRLAKHITYVHSHSKQPPTRV 551
            ||||..|||...::::.|:.|.|.::|||||.:::.|:.:...|..:|:.|..:|:.:::...||
Frog   503 AANPVGGRYERSKSLKHNVNLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHARNEESIERV 567

  Fly   552 KALDMNLMRRYINLCKRKNPTIPDELTDYIVGAYVELRRE-----ARNQKDMTFTSARNLLGILR 611
            .:::.  ::||:...::..|.|..|..::||..|..||:.     |::...:|   .|.|..::|
Frog   568 YSIED--IQRYLLFARQFQPKITKEAEEFIVEQYRRLRQRDGSGVAKSSWRIT---VRQLESLIR 627

  Fly   612 LSTALARLRLSDSVEKDDVAEALRLLEMS 640
            ||.::||:..||.|:...|.||.|||..|
Frog   628 LSESMARMHCSDEVQPKHVKEAFRLLSKS 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm7	NP_523984.1	MCM_N	13..97	CDD:379644	17/84 (20%)
Mcm7	NP_523984.1	MCM	145..641	CDD:214631	203/546 (37%)
mcm6	NP_001016221.1	MCM_N	31..117	CDD:379644	25/125 (20%)
		MCM	123..658	CDD:214631	203/543 (37%)
		Arginine finger	529..532		2/2 (100%)
		MCM6_C	710..819	CDD:375690
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920