DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm7 and mcm2

DIOPT Version :9

Sequence 1:	NP_523984.1	Gene:	Mcm7 / 39014	FlyBaseID:	FBgn0020633	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_001006772.1	Gene:	mcm2 / 448458	XenbaseID:	XB-GENE-999974	Length:	884	Species:	Xenopus tropicalis

Alignment Length:	699	Identity:	233/699 - (33%)
Similarity:	350/699 - (50%)	Gaps:	138/699 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KTFLSEFCKCDDDGKKEFVYGSQLVKLAHREQVLITIDLDDLAEFNESLAEAVVDNCRRYTSIFS 78
            |..:|:.||   :.|:..|...:  .||.||.|        ||.|   |.||..:..:.:.....
Frog   201 KEKISDMCK---ENKESLVVNYE--DLAAREHV--------LAYF---LPEAPAEMLKIFDEAAK 249

  Fly    79 DVIAELLPSYKQ--QEVHAKDALDVYIEHRLMMESRTRNPMEQRDERNSFPSELMKRFEVGFKPL 141
            :|:..:.|.|.:  :|:|      |.|.|..::|
Frog   250 EVVLVMYPKYDRIAREIH------VRISHLPLVE------------------------------- 277

  Fly   142 STEKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRCG---SETYQPVNSLSFTPV 203
                  .:|.::..|:.:|:...|:||.||.|.|.:.:..|.|::|.   ...:|..|. ...|
Frog   278 ------ELRSLRQLHLNQLIRTSGVVTCCTGVLPQLSMVKYNCNKCNFILGPFFQSQNQ-EVKP- 334

  Fly   204 HDCPSDDCRVNKAGGRLYLQTRGSKFVKFQEVKMQEHSDQVPVGHIPRSMTIMCRGEVTRMAQPG 268
            ..||  :|   ::.|...:....:.:..:|.:.:||...:|..|.:|||...:...::....:||
Frog   335 GSCP--EC---QSLGPFEINMEETVYQNYQRITIQESPGKVAAGRLPRSKDAILLADLVDSCKPG 394

  Fly   269 DHIVVSGVF-------------LPLMRTGFAQMIQGLLSETFLQAHRIICINKNDEISDKDA--E 318
            |.|.::|.:             .|:    ||.:|        |..|    |.|.|   ||.|  |
Frog   395 DEIELTGTYHNNYDGSLNTANGFPV----FATVI--------LANH----ITKKD---DKVAVGE 440

  Fly   319 LTPEELE---ELAQDD-FYERLATSLAPEIYGHLDVKKALLLLLVGGVDKRPDGM-KIRGNINIC 378
            ||.|:::   .|::|: ..||:..|:||.||||.|:|:.|.|.|.||..|.|.|. |:||:||:.
Frog   441 LTDEDVKAIVALSKDERIGERIFASIAPSIYGHEDIKRGLALALFGGEAKNPGGKHKVRGDINVL 505

  Fly   379 LMGDPGVAKSQLLGYISRLAVRSQYTTGRGSSGVGLTAAVMKDPLTGEMTLEGGALVLADQGVCC 443
            |.||||.||||.|.|:.::|.|:.:|||:|:|.|||||.|.:.|:|.|.|||.|||||||:|||.
Frog   506 LCGDPGTAKSQFLKYVEKVASRAVFTTGQGASAVGLTAYVQRHPVTKEWTLEAGALVLADRGVCL 570

  Fly   444 IDEFDKMADQDRTAIHEVMEQQTISIAKAGIMTTLNARVSILAAANPAFGRYNPRRTVEQNIQLP 508
            |||||||.|||||:|||.||||:|||:||||:|:|.||.:|:||:||..|||:|..|..:|:.|.
Frog   571 IDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTIIAASNPIGGRYDPSLTFSENVDLT 635

  Fly   509 AALLSRFDLLWLIQDKPDRDNDLRLAKHITYVHSHSKQPPTR----------------VKALDMN 557
            ..::||||:|.:::|..|...|..||:.:  |.||.|..|:.                |:.|...
Frog   636 EPIVSRFDILCVVRDTVDPVQDEMLARFV--VGSHIKHHPSSKDIANGEEFALPNTFGVEPLPQE 698

  Fly   558 LMRRYINLCKRK-NPTIPDELTDYIVGAYVELRREARNQKDMTFTSARNLLGILRLSTALARLRL 621
            ::::||...|.| :|.:.....|.:...|.:||:|:.....:..| .|::..::|::.|.||:.|
Frog   699 VLKKYIMYSKEKIHPKLNQMDQDKVAKMYSDLRKESMATGSIPIT-VRHIESMIRMAEAHARMHL 762

  Fly   622 SDSVEKDDVAEALRLLEMSKDSLNQIHEHQKGHVPNTSDRIFAIVRELA 670
            .|.|.:|||..|:|::      |....:.||..|..:..:.||  |.||
Frog   763 RDYVVEDDVNMAIRVM------LESFIDTQKFSVMRSMRKTFA--RYLA 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm7	NP_523984.1	MCM_N	13..97	CDD:379644	22/84 (26%)
Mcm7	NP_523984.1	MCM	145..641	CDD:214631	198/535 (37%)
mcm2	NP_001006772.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..61
		MCM2_N	44..167	CDD:372227
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..151
		MCM_N	184..272	CDD:379644	24/92 (26%)
		MCM	276..783	CDD:214631	200/578 (35%)
		Arginine finger	640..643		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920