DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm7 and mcm4

DIOPT Version :9

Sequence 1:	NP_523984.1	Gene:	Mcm7 / 39014	FlyBaseID:	FBgn0020633	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_001005655.1	Gene:	mcm4 / 448137	XenbaseID:	XB-GENE-1011481	Length:	863	Species:	Xenopus tropicalis

Alignment Length:	733	Identity:	238/733 - (32%)
Similarity:	367/733 - (50%)	Gaps:	113/733 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RESIKTFLSEFCKCDDDGKKEFVYGSQL---VKLAHREQV------LITIDLDDLAEFNESLAEA 65
            :|..:.|:..|  .|...|:|...|..|   :.:...|::      .:.:|.|.|..|::.|...
Frog   163 KEKFQRFVQRF--IDPLAKEEENVGLDLNEPIYMQRLEEINVVGEPFLNVDCDHLRSFDQDLYRQ 225

  Fly    66 VVDNCRRYTSIFSDVIAELLPSYKQQEVHAKDALDVYIEHRLMMESRTRNPMEQRDERNSFPSEL 130
            :|  |  |..       |::|::...      |.:::.|.                    :|..:
Frog   226 LV--C--YPQ-------EVIPTFDMA------ANEIFFER--------------------YPDSI 253

  Fly   131 MKRFEVGFKPLSTEKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRCGSETYQPV 195
            ::. ::..:|.:..|..::|.:..:.|.:|:|:.|:|.|.:::.|.|..|.:.|..|...|...:
Frog   254 LEH-QIQVRPYNALKTRNMRSLNPEDIDQLITISGMVIRTSQIIPEMQEAFFKCQVCAFTTRVEI 317

  Fly   196 NSLSFTPVHDCPSDDCRVNKAGGRLYLQTRGSKFVKFQEVKMQEHSDQVPVGHIPRSMTIMCRGE 260
            :....:.    ||.....|.......:..| |.|...|.:|:||..:.:|.|..|.:..:....:
Frog   318 DRGRISE----PSVCKHCNTTHSMALIHNR-SMFSDKQMIKLQESPEDMPAGQTPHTTILYGHND 377

  Fly   261 VTRMAQPGDHIVVSGVF--LPLMRTGFAQMIQGLLSETFLQAHRIICINKNDEIS----DKDAE- 318
            :....||||.:.|:|::  :|:......:.::.:. :|.:.   :|...|.|...    |:|.|
Frog   378 LVDKVQPGDRVNVTGIYRAVPIRVNPRVRNVKSVY-KTHID---VIHYRKTDAKRLHGIDEDTEQ 438

  Fly   319 --LTPEE---LEEL-AQDDFYERLATSLAPEIYGHLDVKKALLLLLVGGVDK---RPDGMKIRGN 374
              .|.|.   |:|| |:.|.|||||::|||.||.|.|:||.:||.|.||..|   .....|.|..
Frog   439 KMFTEERVAMLKELAAKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAE 503

  Fly   375 INICLMGDPGVAKSQLLGYISRLAVRSQYTTGRGSSGVGLTAAVMKDPLTGEMTLEGGALVLADQ 439
            :||.|.||||.:|||||.|:..|..|.|||:|:|||.|||||.|||||.|.::.|:.|||||:|.
Frog   504 VNILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDN 568

  Fly   440 GVCCIDEFDKMADQDRTAIHEVMEQQTISIAKAGIMTTLNARVSILAAANPAFGRYNPRRTVEQN 504
            |:|||||||||.:..|:.:||||||||:|||||||:..||||.|:||||||...::||::|..:|
Frog   569 GICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPVESQWNPKKTTIEN 633

  Fly   505 IQLPAALLSRFDLLWLIQDKPDRDNDLRLAKHITYVHSHSKQPPTRVKALDMNLMRRYINLCKR- 568
            ||||..|||||||::|:.|..|...|.|||.|:..::..|:: ..:.:.|||.:::.||...:.
Frog   634 IQLPHTLLSRFDLIFLMLDPQDETYDRRLAHHLVALYYQSEE-QMKEEHLDMAVLKDYIAYARTY 697

  Fly   569 KNPTIPDELTDYIVGAYVELRREARNQKDMTFTSARNLLGILRLSTALARLRLSDSVEKDDVAEA 633
            .||.:.:|.:..::.|||::|: ..:.:.|.....|.|..::|||.|.|::|.|..||..||.||
Frog   698 VNPRLGEEASQALIEAYVDMRK-IGSGRGMVSAYPRQLESLIRLSEAHAKVRFSSKVETIDVEEA 761

  Fly   634 LRL----LEMS-------------------------KDSLNQIHE---HQKGHVPNTS-DRIFAI 665
            .||    |:.|                         |:.|.|:.:   ..||..|... .::|
Frog   762 KRLHREALKQSATDPRTGIVDISILTTGMSATARKRKEELAQVLKKLIQSKGKTPALKYQQLF-- 824

  Fly   666 VRELAGSGKAVKISDIMD 683
             .:|.|...|....|:.|
Frog   825 -EDLRGQSDAAVTKDMFD 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm7	NP_523984.1	MCM_N	13..97	CDD:379644	18/92 (20%)
Mcm7	NP_523984.1	MCM	145..641	CDD:214631	203/541 (38%)
mcm4	NP_001005655.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..121
		PHA03307	<3..>122	CDD:223039
		MCM_N	166..264	CDD:379644	22/137 (16%)
		MCM	267..770	CDD:214631	201/513 (39%)
		Arginine finger	642..645		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920