DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm7 and MCM7

DIOPT Version :9

Sequence 1:	NP_523984.1	Gene:	Mcm7 / 39014	FlyBaseID:	FBgn0020633	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_005907.3	Gene:	MCM7 / 4176	HGNCID:	6950	Length:	719	Species:	Homo sapiens

Alignment Length:	723	Identity:	487/723 - (67%)
Similarity:	596/723 - (82%)	Gaps:	7/723 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MARRDYAQDRESIKTFLSEFCKCDDDGKKEFVYGSQLVKLAHREQVLITIDLDDLAEFNESLAEA 65
            ||.:|||.::|.:|.||.||.:.|:.|||:|.||:|||:|||||||.:.:||||:||.:..|.::
Human     1 MALKDYALEKEKVKKFLQEFYQDDELGKKQFKYGNQLVRLAHREQVALYVDLDDVAEDDPELVDS 65

  Fly    66 VVDNCRRYTSIFSDVIAELLPSYKQQEVHAKDALDVYIEHRLMMESRTRNPMEQRDERNSFPSEL 130
            :.:|.|||..:|:|.:.||||.||::||..||.||||||||||||.|:|:|...|..:|.:|:||
Human    66 ICENARRYAKLFADAVQELLPQYKEREVVNKDVLDVYIEHRLMMEQRSRDPGMVRSPQNQYPAEL 130

  Fly   131 MKRFEVGFKPLSTEKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRCGSETYQPV 195
            |:|||:.|:..|:.|...||||:|..:||||||||||||.:||||.|||||||||:||:|||||:
Human   131 MRRFELYFQGPSSNKPRVIREVRADSVGKLVTVRGIVTRVSEVKPKMVVATYTCDQCGAETYQPI 195

  Fly   196 NSLSFTPVHDCPSDDCRVNKAGGRLYLQTRGSKFVKFQEVKMQEHSDQVPVGHIPRSMTIMCRGE 260
            .|.:|.|:..|||.:|:.|::|||||||||||:|:||||:||||||||||||:||||:|::..||
Human   196 QSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGE 260

  Fly   261 VTRMAQPGDHIVVSGVFLPLMRTGFAQMIQGLLSETFLQAHRIICINKNDEISDKDAELTPEELE 325
            .||:||||||:.|:|:|||::||||.|::|||||||:|:||||:.:||:::......|||.|||.
Human   261 NTRIAQPGDHVSVTGIFLPILRTGFRQVVQGLLSETYLEAHRIVKMNKSEDDESGAGELTREELR 325

  Fly   326 ELAQDDFYERLATSLAPEIYGHLDVKKALLLLLVGGVDKRPDGMKIRGNINICLMGDPGVAKSQL 390
            ::|::||||:||.|:|||||||.|||||||||||||||:.|.|||||||||||||||||||||||
Human   326 QIAEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQSPRGMKIRGNINICLMGDPGVAKSQL 390

  Fly   391 LGYISRLAVRSQYTTGRGSSGVGLTAAVMKDPLTGEMTLEGGALVLADQGVCCIDEFDKMADQDR 455
            |.||.|||.|||||||||||||||||||::|.::||:||||||||||||||||||||||||:.||
Human   391 LSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADR 455

  Fly   456 TAIHEVMEQQTISIAKAGIMTTLNARVSILAAANPAFGRYNPRRTVEQNIQLPAALLSRFDLLWL 520
            |||||||||||||||||||:||||||.|||||||||:|||||||::|||||||||||||||||||
Human   456 TAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWL 520

  Fly   521 IQDKPDRDNDLRLAKHITYVHSHSKQPPTRVKALDMNLMRRYINLCKRKNPTIPDELTDYIVGAY 585
            |||:||||||||||:||||||.||:|||::.:.|||.||||||.:|:.|.|.:|:.|.|||..||
Human   521 IQDRPDRDNDLRLAQHITYVHQHSRQPPSQFEPLDMKLMRRYIAMCREKQPMVPESLADYITAAY 585

  Fly   586 VELRREARNQKDMTFTSARNLLGILRLSTALARLRLSDSVEKDDVAEALRLLEMSKDSLNQIHEH 650
            ||:||||...||.|:||||.||.||||||||||||:.|.|||:||.||:||:|||||||    ..
Human   586 VEMRREAWASKDATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMSKDSL----LG 646

  Fly   651 QKGHVPNT---SDRIFAIVRELAGSGKAVKISDIMDRCTTKGFKPDQVDKCIDDYEELNVWQVNM 712
            .||....|   :|.|||.||||...|::|:.|:...||.::||.|.|....:|:||||||||||.
Human   647 DKGQTARTQRPADVIFATVRELVSGGRSVRFSEAEQRCVSRGFTPAQFQAALDEYEELNVWQVNA 711

  Fly   713 GRTKITFM 720
            .||:|||:
Human   712 SRTRITFV 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm7	NP_523984.1	MCM_N	13..97	CDD:379644	43/83 (52%)
Mcm7	NP_523984.1	MCM	145..641	CDD:214631	369/495 (75%)
MCM7	NP_005907.3	MCM_N	10..93	CDD:405270	42/82 (51%)
		MCM	145..641	CDD:214631	369/495 (75%)
		Arginine finger	513..516		2/2 (100%)
		Interaction with RAD17. /evidence=ECO:0000269\|PubMed:15538388	521..564		32/42 (76%)
		Interaction with ATRIP	577..719		85/145 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147574
Domainoid	1	1.000	386	1.000	Domainoid score	I811
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4323
Inparanoid	1	1.050	988	1.000	Inparanoid score	I309
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54225
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	1	1.000	-	-		FOG0003915
OrthoInspector	1	1.000	-	-		oto88689
orthoMCL	1	0.900	-	-		OOG6_102101
Panther	1	1.100	-	-	LDO	PTHR11630
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R697
SonicParanoid	1	1.000	-	-		X3219
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800