DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm7 and MCM6

DIOPT Version :9

Sequence 1:	NP_523984.1	Gene:	Mcm7 / 39014	FlyBaseID:	FBgn0020633	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_005906.2	Gene:	MCM6 / 4175	HGNCID:	6949	Length:	821	Species:	Homo sapiens

Alignment Length:	682	Identity:	234/682 - (34%)
Similarity:	345/682 - (50%)	Gaps:	116/682 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 FLSEFCKCDDDGKKEFVYGSQLVKLAHREQVLITIDLDDLAEFNESLAEAVVDN--------CRR 72
            ||.||...|.    |..|.....:|...|:..:.:...||.:||:.|:..:.:.        ||
Human    33 FLEEFQSSDG----EIKYLQLAEELIRPERNTLVVSFVDLEQFNQQLSTTIQEEFYRVYPYLCR- 92

  Fly    73 YTSIFSDVIAELLPSYKQQEVHAKDALDVYIEHRLMMESRTRNPMEQRDERNSFPSELMKRFEVG 137
                                     ||..:::                 :|...|  |.|.|.|.
Human    93 -------------------------ALKTFVK-----------------DRKEIP--LAKDFYVA 113

  Fly   138 FKPLSTEKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRCGSETYQPVNSLSFTP 202
            |:.|.|.  |.|||:.:..||.|..:.|.|.|...|.|.:|..|:.|..|.:..........:|.
Human   114 FQDLPTR--HKIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLDCQTVIRDVEQQFKYTQ 176

  Fly   203 VHDCPSDDCRVNKAGGRLYLQTRGSKFVKFQEVKMQEHSDQVPVGHIPRSMTIMCRGEVTRMAQP 267
            .:.|.:..|...:   |..|.|..|:||.||:|::||...::|.|.||||:.::.|.|....||.
Human   177 PNICRNPVCANRR---RFLLDTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQA 238

  Fly   268 GDHIVVSGVFL----------PLMRT----------GF-AQMIQGL--LSETFLQAHRII----C 305
            ||....:|..:          |..|.          |: .:.|:||  |....| ::|::    |
Human   239 GDKCDFTGTLIVVPDVSKLSTPGARAETNSRVSGVDGYETEGIRGLRALGVRDL-SYRLVFLACC 302

  Fly   306 INKND------EISDKDA-------ELTPEELE---ELAQD-DFYERLATSLAPEIYGHLDVKKA 353
            :...:      |:.|::.       ::|.:|.|   |::|| :.|..|.|||.|.|:|:.:||:.
Human   303 VAPTNPRFGGKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRG 367

  Fly   354 LLLLLVGGVDKRP-DGMKIRGNINICLMGDPGVAKSQLLGYISRLAVRSQYTTGRGSSGVGLTAA 417
            :||:|.|||.|.. :|..:||:||:|::|||..||||.|.::...:.|:.||:|:.||..|||||
Human   368 VLLMLFGGVPKTTGEGTSLRGDINVCIVGDPSTAKSQFLKHVEEFSPRAVYTSGKASSAAGLTAA 432

  Fly   418 VMKDPLTGEMTLEGGALVLADQGVCCIDEFDKMADQDRTAIHEVMEQQTISIAKAGIMTTLNARV 482
            |::|..:.|..:|.|||:|||.|||||||||||..:|:.||||.||||||||.|||:..|||||.
Human   433 VVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKATLNART 497

  Fly   483 SILAAANPAFGRYNPRRTVEQNIQLPAALLSRFDLLWLIQDKPDRDNDLRLAKHITYVHSHSKQP 547
            ||||||||..|.|:..::::|||.|.|.::|||||.:::.|:.:...|..:|:.|..:||..::.
Human   498 SILAAANPISGHYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRIEES 562

  Fly   548 PTRVKALDMNLMRRYINLCKRKNPTIPDELTDYIVGAYVELRREARNQKDMTFTS----ARNLLG 608
            ..||.:||.  :|||:...::..|.|..|..|:||..|..||:  |:...:|.:|    .|.|..
Human   563 IDRVYSLDD--IRRYLLFARQFKPKISKESEDFIVEQYKHLRQ--RDGSGVTKSSWRITVRQLES 623

  Fly   609 ILRLSTALARLRLSDSVEKDDVAEALRLLEMS 640
            ::|||.|:||:...|.|:...|.||.|||..|
Human   624 MIRLSEAMARMHCCDEVQPKHVKEAFRLLNKS 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm7	NP_523984.1	MCM_N	13..97	CDD:379644	16/88 (18%)
Mcm7	NP_523984.1	MCM	145..641	CDD:214631	207/545 (38%)
MCM6	NP_005906.2	MCM_N	27..114	CDD:405270	24/129 (19%)
		MCM	119..657	CDD:214631	208/547 (38%)
		Arginine finger	528..531		2/2 (100%)
		MCM6_C	713..817	CDD:408078
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820