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Protein Alignment Mcm7 and MCM4

DIOPT Version :9

Sequence 1:	NP_523984.1	Gene:	Mcm7 / 39014	FlyBaseID:	FBgn0020633	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_005905.2	Gene:	MCM4 / 4173	HGNCID:	6947	Length:	863	Species:	Homo sapiens

Alignment Length:	678	Identity:	229/678 - (33%)
Similarity:	347/678 - (51%)	Gaps:	110/678 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 ITIDL-------DDLAEFNESLAEAVV------------DNCRRYTSIFSDVIAE---------L 84
            :.:||       :|:....:||.:.:|            :|.:|:...|.|.:|:         .
Human   125 LQVDLQSDGAAAEDIVASEQSLGQKLVIWGTDVNVAACKENFQRFLQRFIDPLAKEEENVGIDIT 189

  Fly    85 LPSYKQQ----EVHAKDALDVYIEHRLMMESRTRNPMEQRDERNSFPSELMKRF----------- 134
            .|.|.|:    .|..:..|:|..||   ::|..:|...|   ..|:|.|::..|
Human   190 EPLYMQRLGEINVIGEPFLNVNCEH---IKSFDKNLYRQ---LISYPQEVIPTFDMAVNEIFFDR 248

  Fly   135 --------EVGFKPLSTEKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRCGSET 191
                    ::..:|.:..|..::|.:..:.|.:|:|:.|:|.|.:::.|.|..|.:.|..|...|
Human   249 YPDSILEHQIQVRPFNALKTKNMRNLNPEDIDQLITISGMVIRTSQLIPEMQEAFFQCQVCAHTT 313

  Fly   192 YQPVNSLSFTPVHDCPSDDCRVNKAGGRLYLQTRGSKFVKFQEVKMQEHSDQVPVGHIPRSMTIM 256
            ...::......    ||...|.:.......:..| |.|...|.:|:||..:.:|.|..|.::.:.
Human   314 RVEMDRGRIAE----PSVCGRCHTTHSMALIHNR-SLFSDKQMIKLQESPEDMPAGQTPHTVILF 373

  Fly   257 CRGEVTRMAQPGDHIVVSGVF--LPL---------------------MRTGFAQMIQGLLSETFL 298
            ...::....||||.:.|:|::  :|:                     .|...|:.:.||..|.
Human   374 AHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEA-- 436

  Fly   299 QAHRIICINKNDEISDKDAELTPEELEELA-QDDFYERLATSLAPEIYGHLDVKKALLLLLVGGV 362
                     :....|:|..||    |:||: :.|.|||||::|||.||.|.|:||.:||.|.||.
Human   437 ---------EQKLFSEKRVEL----LKELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGT 488

  Fly   363 DK---RPDGMKIRGNINICLMGDPGVAKSQLLGYISRLAVRSQYTTGRGSSGVGLTAAVMKDPLT 424
            .|   .....|.|..|||.|.||||.:|||||.|:..|..|.|||:|:|||.|||||.|||||.|
Human   489 RKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPET 553

  Fly   425 GEMTLEGGALVLADQGVCCIDEFDKMADQDRTAIHEVMEQQTISIAKAGIMTTLNARVSILAAAN 489
            .::.|:.|||||:|.|:|||||||||.:..|:.:||||||||:|||||||:..||||.|:|||||
Human   554 RQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAAN 618

  Fly   490 PAFGRYNPRRTVEQNIQLPAALLSRFDLLWLIQDKPDRDNDLRLAKHITYVHSHSKQPPTRVKAL 554
            |...::||::|..:|||||..|||||||::|:.|..|...|.|||.|:..::..|:: ....:.|
Human   619 PIESQWNPKKTTIENIQLPHTLLSRFDLIFLLLDPQDEAYDRRLAHHLVALYYQSEE-QAEEELL 682

  Fly   555 DMNLMRRYINLCKRK-NPTIPDELTDYIVGAYVELRREARNQKDMTFTSARNLLGILRLSTALAR 618
            ||.:::.||...... .|.:.:|.:..::.|||::|: ..:.:.|.....|.|..::||:.|.|:
Human   683 DMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVDMRK-IGSSRGMVSAYPRQLESLIRLAEAHAK 746

  Fly   619 LRLSDSVEKDDVAEALRLLEMSKDSLNQ 646
            :|||:.||..||.||.||   .:::|.|
Human   747 VRLSNKVEAIDVEEAKRL---HREALKQ 771

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.