Protein Alignment Mcm7 and MCM3

DIOPT Version :9

• Sequence 1: NP_523984.1
• Gene: Mcm7 / 39014
• FlyBaseID: FBgn0020633
• Length: 720
• Species: Drosophila melanogaster
• Sequence 2: NP_001353298.1
• Gene: MCM3 / 4172
• HGNCID: 6945
• Length: 833
• Species: Homo sapiens
• Alignment Length: 757
• Identity: 241/757 - (31%)
• Similarity: 360/757 - (47%)
• Gaps: 168/757 - (22%)

  Fly     2 ARRDYAQDRESIKTFLSEFCKCDDDGKKEFVYGSQLVKLAHREQVLITIDLDDLAEFNESLAEAV 66
            |:|||..       ||       ||.:.:.:|.|::.:|....|..:.::::||...||..|..:
Human    15 AQRDYLD-------FL-------DDEEDQGIYQSKVRELISDNQYRLIVNVNDLRRKNEKRANRL 65

  Fly    67 VDNCRR----YTSIFSDVIAELLPSYKQQEVHAKDALDVYIEHRLMMESRTRNPMEQRDERNSFP 127
            ::|...    :.....|.:|.:..:|.:|
Human    66 LNNAFEELVAFQRALKDFVASIDATYAKQ------------------------------------ 94

  Fly   128 SELMKRFEVGFKPLSTEKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTC---DRCGS 189
               .:.|.||.:.....|..|.|.:.:..:..:|.|.||||:|:.|:|.:|.:.:.|   .:...
Human    95 ---YEEFYVGLEGSFGSKHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIE 156

  Fly   190 ETYQPVNSL-SFTPVHDCPSDDCRVNKAGGRLYLQTRG--SKFVKFQEVKMQEHSDQVPVGHIPR 251
            ..|..:.:| :|......|:.|...|.      |:|..  |.:...|.:.:||..::.|.|.:||
Human   157 RRYSDLTTLVAFPSSSVYPTKDEENNP------LETEYGLSVYKDHQTITIQEMPEKAPAGQLPR 215

  Fly   252 SMTIMCRGEVTRMAQPGDHIVVSGVF--LPLMRTGFAQMIQGLLSETFLQAHRIICINKNDEISD 314
            |:.::...::...|:|||.:.|.|.:  ||..:.|:.       |.||    |.:.|..|.:...
Human   216 SVDVILDDDLVDKAKPGDRVQVVGTYRCLPGKKGGYT-------SGTF----RTVLIACNVKQMS 269

  Fly   315 KDAE--LTPEELEELAQ------DDFYERLATSLAPEIYGHLDVKKALLLLLVGGVDK-RPDGMK 370
            |||:  .:.|::.::.:      .|.:::||.||||.|:||..||||:|.||:|||:: ..:|..
Human   270 KDAQPSFSAEDIAKIKKFSKTRSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSH 334

  Fly   371 IRGNINICLMGDPGVAKSQLLGYISRLAVRSQYTTGRGSSGVGLTAAVMKDPLTGEMTLEGGALV 435
            |||:|||.|:|||.|||||||.|:...|.|:..|||||||||||||||..|..|||..||.||:|
Human   335 IRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMV 399

  Fly   436 LADQGVCCIDEFDKMADQDRTAIHEVMEQQTISIAKAGIMTTLNARVSILAAANPAFGRYNPRRT 500
            |||:||.||||||||:|.|||||||||||..::||||||...||||.|:||||||.:|||:..:|
Human   400 LADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKT 464

  Fly   501 VEQNIQLPAALLSRFDLLWLIQDKPDRDNDLRLAKHITYVH------------------------ 541
            ..:||.|..:||||||||:::.|:.|.:.|..::.|:..:|
Human   465 PMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYRAPGEQDGDAMPLGSAVDILAT 529

  Fly   542 -----SHSKQPPTRV----------------KALDMNLMRRYINLCKRKNPTIPDELTDYIVGAY 585
                 |...|..|::                |.:....|::||::.|...|.:..|...||...|
Human   530 DDPNFSQEDQQDTQIYEKHDNLLHGTKKKKEKMVSAAFMKKYIHVAKIIKPVLTQESATYIAEEY 594

  Fly   586 VELRREARNQKDMTFTS---ARNLLGILRLSTALARLRLSDSVEKDDVAEALRLL---------- 637
            ..||.:.....|...||   ||.|..::||:||.|:.|:|.:|:..|..||:.|:
Human   595 SRLRSQDSMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLE 659

  Fly   638 -------------------EMSKDSLNQIHEHQKGHVPNTSD 660
                               |.|::...|..:.:|...|:..|
Human   660 KEKKRKKRSEDESETEDEEEKSQEDQEQKRKRRKTRQPDAKD 701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm7	NP_523984.1	MCM_N	13..97	CDD:379644	18/87 (21%)
		MCM	145..641	CDD:214631	211/589 (36%)
MCM3	NP_001353298.1	MCM_N	19..104	CDD:317013	22/137 (16%)
		MCM	109..654	CDD:214631	210/561 (37%)
		Arginine finger	477..480		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	662..739		6/40 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920