DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mcm7 and MCM2

DIOPT Version :9

Sequence 1:NP_523984.1 Gene:Mcm7 / 39014 FlyBaseID:FBgn0020633 Length:720 Species:Drosophila melanogaster
Sequence 2:NP_004517.2 Gene:MCM2 / 4171 HGNCID:6944 Length:904 Species:Homo sapiens


Alignment Length:704 Identity:218/704 - (30%)
Similarity:345/704 - (49%) Gaps:153/704 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 KTFLSEFCKCDDDGKKEFVYGSQLVKLAHREQVLITIDLDDLAEFNESLAEAVVDNCRRYTSIFS 78
            |..:|:.||   :.::..|...:  .||.||.|        ||.|   |.||..:..:.:.....
Human   216 KERISDMCK---ENRESLVVNYE--DLAAREHV--------LAYF---LPEAPAELLQIFDEAAL 264

  Fly    79 DVIAELLPSYKQQEVHAKDALDVYIEHRLMMESRTRNPMEQRDERNSFPSELMKRFEVGFKPLST 143
            :|:..:.|.|.:...|    :.|.|.|..::|                                 
Human   265 EVVLAMYPKYDRITNH----IHVRISHLPLVE--------------------------------- 292

  Fly   144 EKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRCG----------SETYQPVNSL 198
                .:|.::..|:.:|:...|:||.||.|.|.:.:..|.|::|.          ::..:|    
Human   293 ----ELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCNKCNFVLGPFCQSQNQEVKP---- 349

  Fly   199 SFTPVHDCPSDDCRVNKAGGRLYLQTRGSKFVKFQEVKMQEHSDQVPVGHIPRSMTIMCRGEVTR 263
                 ..||  :|   ::.|...:....:.:..:|.:::||...:|..|.:|||...:...::..
Human   350 -----GSCP--EC---QSAGPFEVNMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLADLVD 404

  Fly   264 MAQPGDHIVVSGVF-------------LPLMRTGFAQMIQGLLSETFLQAHRIICINKND----- 310
            ..:|||.|.::|::             .|:    ||.:|        |..|    :.|.|     
Human   405 SCKPGDEIELTGIYHNNYDGSLNTANGFPV----FATVI--------LANH----VAKKDNKVAV 453

  Fly   311 -EISDKDAELTPEELEELAQD-DFYERLATSLAPEIYGHLDVKKALLLLLVGGVDKRPDGM-KIR 372
             |::|:|.::    :..|::| ...|::..|:||.||||.|:|:.|.|.|.||..|.|.|. |:|
Human   454 GELTDEDVKM----ITSLSKDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVR 514

  Fly   373 GNINICLMGDPGVAKSQLLGYISRLAVRSQYTTGRGSSGVGLTAAVMKDPLTGEMTLEGGALVLA 437
            |:||:.|.||||.||||.|.||.:::.|:.:|||:|:|.|||||.|.:.|::.|.|||.||||||
Human   515 GDINVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLA 579

  Fly   438 DQGVCCIDEFDKMADQDRTAIHEVMEQQTISIAKAGIMTTLNARVSILAAANPAFGRYNPRRTVE 502
            |:|||.|||||||.|||||:|||.||||:|||:||||:|:|.||.:::|||||..|||:|..|..
Human   580 DRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFS 644

  Fly   503 QNIQLPAALLSRFDLLWLIQDKPDRDNDLRLAKHITYVHSHSKQPPTR----------------- 550
            :|:.|...::||||:|.:::|..|...|..||:.:  |.||.:..|:.                 
Human   645 ENVDLTEPIISRFDILCVVRDTVDPVQDEMLARFV--VGSHVRHHPSNKEEEGLANGSAAEPAMP 707

  Fly   551 ----VKALDMNLMRRYINLCK-RKNPTIPDELTDYIVGAYVELRREARNQKDMTFTSARNLLGIL 610
                |:.|...::::||...| |.:|.:.....|.:...|.:||:|:.....:..| .|::..::
Human   708 NTYGVEPLPQEVLKKYIIYAKERVHPKLNQMDQDKVAKMYSDLRKESMATGSIPIT-VRHIESMI 771

  Fly   611 RLSTALARLRLSDSVEKDDVAEALRLLEMSKDSLNQIHEHQKGHVPNTSDRIFA 664
            |::.|.||:.|.|.|.:|||..|:|::      |....:.||..|..:..:.||
Human   772 RMAEAHARIHLRDYVIEDDVNMAIRVM------LESFIDTQKFSVMRSMRKTFA 819

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mcm7NP_523984.1 MCM_N 13..97 CDD:379644 20/82 (24%)
MCM 145..641 CDD:214631 188/548 (34%)
MCM2NP_004517.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..80
Interaction with KAT7. /evidence=ECO:0000250 2..257 16/56 (29%)
MCM2_N 73..182 CDD:403724
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 109..167
MCM_N 197..286 CDD:405270 21/89 (24%)
MCM 291..803 CDD:214631 190/591 (32%)
Arginine finger 655..658 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 686..705 1/18 (6%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1241
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D232729at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

Return to query results.
Submit another query.