DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm7 and Mcm5

DIOPT Version :9

Sequence 1:	NP_523984.1	Gene:	Mcm7 / 39014	FlyBaseID:	FBgn0020633	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_524308.2	Gene:	Mcm5 / 41296	FlyBaseID:	FBgn0017577	Length:	733	Species:	Drosophila melanogaster

Alignment Length:	762	Identity:	242/762 - (31%)
Similarity:	375/762 - (49%)	Gaps:	147/762 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RESIKTFLSE--FCKCDDDGKKEFVYGSQLVKLAHREQVLITIDLDDLAEFNESLAEAVVDNCRR 72
            :|.|:||..|  |.|..|..|:.::.|          :..:.|:::||..|:|:||:.:......
  Fly    35 KEFIRTFNEENFFYKYRDTLKRNYLNG----------RYFLEIEMEDLVGFDETLADKLNKQPTE 89

  Fly    73 YTSIFS----DVIAELLPSYKQQEVHAKDALDVYIEHRLMMESRTRNPMEQRDERNSFPSELMKR 133
            :..||.    :|..|:.....:.|.|..|.       ::::.|            |:.|:
  Fly    90 HLEIFEEAAREVADEITAPRPEHEEHMHDI-------QILLSS------------NANPT----- 130

  Fly   134 FEVGFKPLSTEKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRCGSETYQPVNSL 198
                          :||::|:..:.|||.:.||:...:.:.......:..|..|.:    .:.:|
  Fly   131 --------------NIRQLKSDCVSKLVKIAGIIVAASGISAKATRMSIQCLSCST----VIPNL 177

  Fly   199 SFTP---VHDCPSDDCRVNKAG------GRLYLQTRGSKFVKFQEVKMQEHSDQVPVGHIPRSMT 254
            ...|   .:..|. .|...:||      ...::.....|.|.||.:|:||..|.||.|.|||.:.
  Fly   178 KVNPGLEGYALPR-KCNTEQAGRPKCPLDPFFIMPDKCKCVDFQTLKLQELPDFVPQGEIPRHLQ 241

  Fly   255 IMCRGEVTRMAQPGDHIVVSGVF------LPLMRTGFAQMIQGLLSETFLQAHRIICINKNDE-- 311
            :.|...:.....||:.:::.|::      .|..|.|..:.:.|:.:...    |::.|..:.|
  Fly   242 LFCDRSLCERVVPGNRVLIQGIYSIRKVGKPSRRDGREKAVVGVRAPYM----RVVGITVDSEGA 302

  Fly   312 --ISDKDAELTPEELEEL----AQDDFYERLATSLAPEIYGHLDVKKALLLLLVGGVDKR-PDGM 369
              || :.:.:|.:|.|..    |..|.||||:.||||.|:|..|:|||:..:|.||..|| |||:
  Fly   303 GAIS-RYSNITSDEEEHFRRMAASGDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRLPDGL 366

  Fly   370 KIRGNINICLMGDPGVAKSQLLGYISRLAVRSQYTTGRGSSGVGLTAAVMKDPLTGEMTLEGGAL 434
            ..||:||:.|:||||.||||||.::.::|..:.||:|:|||..||||:|||||.|....:||||:
  Fly   367 CRRGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGKGSSAAGLTASVMKDPQTRNFVMEGGAM 431

  Fly   435 VLADQGVCCIDEFDKMADQDRTAIHEVMEQQTISIAKAGIMTTLNARVSILAAANPAFGRYNPRR 499
            ||||.||.||||||||.:.||.||||.|||||||||||||.||||:|.|:|||||..|||::..:
  Fly   432 VLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDTK 496

  Fly   500 TVEQNIQLPAALLSRFDLLWLIQDKPDRDNDLRLAKHITYVH-SHSKQPPTRVK--ALDMNLMRR 561
            . |:||.....:|||||::::::|..|...|:.|||||..|| |.:|..|:...  .:.::..::
  Fly   497 G-EENIDFMPTILSRFDMIFIVKDIHDESRDITLAKHIINVHLSSNKSAPSEPAEGEISLSTFKK 560

  Fly   562 YINLCKRK-NPTIPDELTDYIVGAYVELR-----REARNQKDMTF-TSARNLLGILRLSTALARL 619
            ||:.|:.. .|.:.:...:.:...||.:|     :|..:.|.::. .:.|.|..::|:|.:||::
  Fly   561 YIHYCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKRLSIPITVRQLEAVIRISESLAKI 625

  Fly   620 RLSDSVEKDDVAEALRLLEMS---------------------KDSLNQIHEHQKGHVPNTSDRIF 663
            ||......:.|.|||||.::|                     :::||:|.:..|        |.|
  Fly   626 RLQPFATDEHVNEALRLFQVSTLDAAMTGSLAGAEGFTTEEDQETLNRIEKQLK--------RRF 682

  Fly   664 AIVRELAGSGKAVKISDIMDRCTTKGFKPDQVDKCIDDYEELNVWQV 710
            ||       |..|...:|:.            |.....|||..|.:|
  Fly   683 AI-------GSQVSEQNILQ------------DFLRQKYEERTVMKV 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm7	NP_523984.1	MCM_N	13..97	CDD:379644	22/89 (25%)
Mcm7	NP_523984.1	MCM	145..641	CDD:214631	198/550 (36%)
Mcm5	NP_524308.2	MCM_N	31..124	CDD:405270	24/105 (23%)
Mcm5	NP_524308.2	MCM	128..648	CDD:214631	199/549 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446132
Domainoid	1	1.000	52	1.000	Domainoid score	I661
eggNOG	1	0.900	-	-		E1_COG1241
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D15169at50557
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11630
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850