DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm7 and mei-218

DIOPT Version :9

Sequence 1:	NP_523984.1	Gene:	Mcm7 / 39014	FlyBaseID:	FBgn0020633	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_001027068.1	Gene:	mei-218 / 3772646	FlyBaseID:	FBgn0002709	Length:	1186	Species:	Drosophila melanogaster

Alignment Length:	743	Identity:	133/743 - (17%)
Similarity:	230/743 - (30%)	Gaps:	275/743 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 EFNESLAEAVVDNCRRYTSIFSDVIAELLPSYKQQ----------EVHAKDAL------------ 99
            ||.|||.|.         |.......|::| |:||          |:||...:
  Fly   484 EFTESLLEG---------SSGKTPEKEVVP-YQQQEKPRQVKSSPEIHASSHMRKLAMGSVLNSN 538

  Fly   100 --------DVYIEHRLMMESRTR--------------NPMEQRDERNSFPSELMK-RFEVGFKPL 141
                    :.::.|::...|:.|              ||.||....:|.|..::: ..|:..:|
  Fly   539 AKEFHPTGESHLTHKVSRLSQRRCRQRFTRSLHAKKNNPREQLPNPDSAPEPILEYTSEIDDQP- 602

  Fly   142 STEKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRCGSETYQPVNSLSFTPVHDC 206
                                        |   .|...|.|            |:.::       .
  Fly   603 ----------------------------C---PPRQTVDT------------PIEAI-------V 617

  Fly   207 PSDDCRVNKAGGR---LYLQTRGSKFVKFQEVKMQEHSDQVPV--------GHIPRSMTIMCRGE 260
            |.....|:..|..   .|...:..       :.....|.|:||        ..:.|..::.|.|.
  Fly   618 PPAMIEVSATGNLPPVFYFDQQSG-------IIWSNSSPQIPVEIQSNSVSQSVFRLASLPCTGV 675

  Fly   261 -------VTRMAQPGDHIVVSGVFLPLMRTGFAQMIQGLLSETFLQAHR----IICINKNDEIS- 313
                   .|....|..|  :|...||...:|..|:...|.|......|:    ..||::::::.
  Fly   676 GTTNMDIFTSSPPPIQH--MSSSRLPSSISGPTQLSHTLSSPPVENQHQQHLWESCIHQDEDLMY 738

  Fly   314 -----DKDAELT-PE----------ELE--------ELAQDDFYER---LATSLAPEIYGHL--- 348
                 |.|.|.| ||          |:|        ::..|:..|.   ||....|.:..|:
  Fly   739 SRPLLDMDQEETQPEQQDQEWQWESEIEPPSFQSENQVVADEHGEENAYLAKDAGPPLERHMIFR 803

  Fly   349 -------------------DVKK----------------AL------------------LLLLVG 360
                               .:||                ||                  ::||..
  Fly   804 APSQHGQEYPKPDLNCVPSSIKKLHHLISSQYSDYSFVYALSAQISQDCVPMDCFVYLKMILLAS 868

  Fly   361 GVDKRPDGMKIRGNINICLMGDPGVAKSQLLGYISRLAVRSQYTTGRGSSGVGLTAAVMKDPLTG 425
            .|....|  ::|..|::|::....:..::||..:.:||.|.     .|....||.......| |.
  Fly   869 IVSIESD--EVRAPISLCIIATDSLMANRLLNKVGQLAPRF-----LGPHEYGLQPTFNALP-TR 925

  Fly   426 EMTLEGGALVLADQGVCCIDEFDKMADQDRTAIHEVMEQQTISIAKAGIMTTLNARVSILAAANP 490
            ...:....|:||.|||....::::::......:.:.:|...:.:.:..|...|.|.|
  Fly   926 FNWIVASPLLLAQQGVYYAGDWNRLSKDQGCQLEKCIENGAVPVPQLHIDQPLKAAV-------- 982

  Fly   491 AFGRYNPRRTVEQNIQLPAALLSRFDL-----------LWLIQDKPDRDNDLRLAKHITYVHSHS 544
             :..:.|..:..|.:.| |.|...|.|           ||         |.:        :..|:
  Fly   983 -WTYWQPNNSTNQTLAL-AKLCPIFGLPIYMGAQASNSLW---------NSI--------IQKHN 1028

  Fly   545 KQPPTRVK---ALDMNLMRRYINLCKRKNPTIPDELTDYIVGAYVELRREARNQKDMTFTSARNL 606
            .:....|.   ::..:.||..|:|..::..|:.|.....:...||..|:|..|     ..|::..
  Fly  1029 AEGQIVVNDGLSIPEDDMRMLIHLLHQRKTTLTDGAQHMLQKYYVISRKERPN-----VFSSKTY 1088

  Fly   607 LGILRLSTALARLRLSDSVEKDDVAEAL 634
            :.:.:|:...|:|.|...|.:.||..|:
  Fly  1089 IVLKQLAECFAKLALRLEVLESDVCVAI 1116

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm7	NP_523984.1	MCM_N	13..97	CDD:379644	15/49 (31%)
Mcm7	NP_523984.1	MCM	145..641	CDD:214631	107/610 (18%)
mei-218	NP_001027068.1	PTZ00112	122..>417	CDD:240274
mei-218	NP_001027068.1	MCM	<1023..1116	CDD:278895	21/105 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11630
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100