Protein Alignment Mcm7 and mei-218

DIOPT Version :10

• Sequence 1: NP_523984.1
• Gene: Mcm7 / 39014
• FlyBaseID: FBgn0020633
• Length: 720
• Species: Drosophila melanogaster
• Sequence 2: NP_728052.2
• Gene: mei-218 / 3772646
• FlyBaseID: FBgn0002709
• Length: 1186
• Species: Drosophila melanogaster
• Alignment Length: 743
• Identity: 133/743 - (17%)
• Similarity: 230/743 - (30%)
• Gaps: 275/743 - (37%)

  Fly    57 EFNESLAEAVVDNCRRYTSIFSDVIAELLPSYKQQ----------EVHAKDAL------------ 99
            ||.|||.|.         |.......|::| |:||          |:||...:
  Fly   484 EFTESLLEG---------SSGKTPEKEVVP-YQQQEKPRQVKSSPEIHASSHMRKLAMGSVLNSN 538

  Fly   100 --------DVYIEHRLMMESRTR--------------NPMEQRDERNSFPSELMK-RFEVGFKPL 141
                    :.::.|::...|:.|              ||.||....:|.|..::: ..|:..:|
  Fly   539 AKEFHPTGESHLTHKVSRLSQRRCRQRFTRSLHAKKNNPREQLPNPDSAPEPILEYTSEIDDQP- 602

  Fly   142 STEKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRCGSETYQPVNSLSFTPVHDC 206
                                        |   .|...|.|            |:.::       .
  Fly   603 ----------------------------C---PPRQTVDT------------PIEAI-------V 617

  Fly   207 PSDDCRVNKAGGR---LYLQTRGSKFVKFQEVKMQEHSDQVPV--------GHIPRSMTIMCRGE 260
            |.....|:..|..   .|...:..       :.....|.|:||        ..:.|..::.|.|.
  Fly   618 PPAMIEVSATGNLPPVFYFDQQSG-------IIWSNSSPQIPVEIQSNSVSQSVFRLASLPCTGV 675

  Fly   261 -------VTRMAQPGDHIVVSGVFLPLMRTGFAQMIQGLLSETFLQAHR----IICINKNDEIS- 313
                   .|....|..|  :|...||...:|..|:...|.|......|:    ..||::::::.
  Fly   676 GTTNMDIFTSSPPPIQH--MSSSRLPSSISGPTQLSHTLSSPPVENQHQQHLWESCIHQDEDLMY 738

  Fly   314 -----DKDAELT-PE----------ELE--------ELAQDDFYER---LATSLAPEIYGHL--- 348
                 |.|.|.| ||          |:|        ::..|:..|.   ||....|.:..|:
  Fly   739 SRPLLDMDQEETQPEQQDQEWQWESEIEPPSFQSENQVVADEHGEENAYLAKDAGPPLERHMIFR 803

  Fly   349 -------------------DVKK----------------AL------------------LLLLVG 360
                               .:||                ||                  ::||..
  Fly   804 APSQHGQEYPKPDLNCVPSSIKKLHHLISSQYSDYSFVYALSAQISQDCVPMDCFVYLKMILLAS 868

  Fly   361 GVDKRPDGMKIRGNINICLMGDPGVAKSQLLGYISRLAVRSQYTTGRGSSGVGLTAAVMKDPLTG 425
            .|....|  ::|..|::|::....:..::||..:.:||.|.     .|....||.......| |.
  Fly   869 IVSIESD--EVRAPISLCIIATDSLMANRLLNKVGQLAPRF-----LGPHEYGLQPTFNALP-TR 925

  Fly   426 EMTLEGGALVLADQGVCCIDEFDKMADQDRTAIHEVMEQQTISIAKAGIMTTLNARVSILAAANP 490
            ...:....|:||.|||....::::::......:.:.:|...:.:.:..|...|.|.|
  Fly   926 FNWIVASPLLLAQQGVYYAGDWNRLSKDQGCQLEKCIENGAVPVPQLHIDQPLKAAV-------- 982

  Fly   491 AFGRYNPRRTVEQNIQLPAALLSRFDL-----------LWLIQDKPDRDNDLRLAKHITYVHSHS 544
             :..:.|..:..|.:.| |.|...|.|           ||         |.:        :..|:
  Fly   983 -WTYWQPNNSTNQTLAL-AKLCPIFGLPIYMGAQASNSLW---------NSI--------IQKHN 1028

  Fly   545 KQPPTRVK---ALDMNLMRRYINLCKRKNPTIPDELTDYIVGAYVELRREARNQKDMTFTSARNL 606
            .:....|.   ::..:.||..|:|..::..|:.|.....:...||..|:|..|     ..|::..
  Fly  1029 AEGQIVVNDGLSIPEDDMRMLIHLLHQRKTTLTDGAQHMLQKYYVISRKERPN-----VFSSKTY 1088

  Fly   607 LGILRLSTALARLRLSDSVEKDDVAEAL 634
            :.:.:|:...|:|.|...|.:.||..|:
  Fly  1089 IVLKQLAECFAKLALRLEVLESDVCVAI 1116

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm7	NP_523984.1	MCM_N	10..103	CDD:464206	15/75 (20%)
		MCM	145..641	CDD:475121	107/610 (18%)
mei-218	NP_728052.2	PTZ00112	122..>417	CDD:240274
		SP1-4_N	<152..>287	CDD:425404
		MCM	862..1116	CDD:475121	59/293 (20%)
		MCM_lid	1044..1116	CDD:465534	19/76 (25%)