Protein Alignment Mcm7 and Mcm4

DIOPT Version :9

• Sequence 1: NP_523984.1
• Gene: Mcm7 / 39014
• FlyBaseID: FBgn0020633
• Length: 720
• Species: Drosophila melanogaster
• Sequence 2: NP_387500.1
• Gene: Mcm4 / 29728
• RGDID: 3060
• Length: 862
• Species: Rattus norvegicus
• Alignment Length: 678
• Identity: 226/678 - (33%)
• Similarity: 344/678 - (50%)
• Gaps: 110/678 - (16%)

  Fly    48 ITIDL-------DDLAEFNESLAEAVV------------DNCRRYTSIFSDVIAE---------L 84
            :.:||       :|.....:||.:.:|            ::.:|:...|:|.:|:         .
  Rat   124 LQVDLQSDGAAAEDTVASEQSLGQKLVIWGTDVNVATCKEHFQRFLQCFTDPLAKEEENVGIDIT 188

  Fly    85 LPSYKQQ----EVHAKDALDVYIEHRLMMESRTRNPMEQRDERNSFPSELMKRF----------- 134
            .|.|.|:    .:..:..|:|..||   ::|..:|...|   ..|:|.|::..|
  Rat   189 QPLYMQRLGEINITGEPFLNVNCEH---IKSFGKNLYRQ---LISYPQEVIPTFDMAVNEIFFDR 247

  Fly   135 --------EVGFKPLSTEKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRCGSET 191
                    ::..:|.:..|..|:|.:..:.|.:|:|:.|:|.|.:::.|.|..|.:.|..|...|
  Rat   248 YPDSILEHQIQVRPFNALKTKSMRNLNPEDIDQLITISGMVIRTSQLIPEMQEAFFQCQVCAHTT 312

  Fly   192 YQPVNSLSFTPVHDCPSDDCRVNKAGGRLYLQTRGSKFVKFQEVKMQEHSDQVPVGHIPRSMTIM 256
            ...::....  ...|....|....:   :.|....|.|...|.:|:||..:.:|.|..|.::.:.
  Rat   313 RVEMDRGRI--AEPCTCVHCHTTHS---MALIHNRSLFSDKQMIKLQESPEDMPAGQTPHTVVLF 372

  Fly   257 CRGEVTRMAQPGDHIVVSGVF--LPL---------------------MRTGFAQMIQGLLSETFL 298
            ...::....||||.:.|:|::  :|:                     .|...|:.:.||..|.
  Rat   373 AHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEA-- 435

  Fly   299 QAHRIICINKNDEISDKDAELTPEELEELA-QDDFYERLATSLAPEIYGHLDVKKALLLLLVGGV 362
                     :....|:|..:|    |:||: :.|.|||||::|||.||.|.|:||.:||.|.||.
  Rat   436 ---------EQKLFSEKRVKL----LKELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGT 487

  Fly   363 DK---RPDGMKIRGNINICLMGDPGVAKSQLLGYISRLAVRSQYTTGRGSSGVGLTAAVMKDPLT 424
            .|   .....|.|..|||.|.||||.:|||||.|:..|..|.|||:|:|||.|||||.|||||.|
  Rat   488 RKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPET 552

  Fly   425 GEMTLEGGALVLADQGVCCIDEFDKMADQDRTAIHEVMEQQTISIAKAGIMTTLNARVSILAAAN 489
            .::.|:.|||||:|.|:|||||||||.:..|:.:||||||||:|||||||:..||||.|:|||||
  Rat   553 RQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAAN 617

  Fly   490 PAFGRYNPRRTVEQNIQLPAALLSRFDLLWLIQDKPDRDNDLRLAKHITYVHSHSKQPPTRVKAL 554
            |...::||::|..:|||||..|||||||::|:.|..|...|.|||.|:..::..|:: ....:.|
  Rat   618 PIESQWNPKKTTIENIQLPHTLLSRFDLIFLMLDPQDEAYDRRLAHHLVSLYYQSEE-QVEQEFL 681

  Fly   555 DMNLMRRYINLCKRK-NPTIPDELTDYIVGAYVELRREARNQKDMTFTSARNLLGILRLSTALAR 618
            ||.:::.||...... .|.:.:|.:..::.|||.:|: ..:.:.|.....|.|..::||:.|.|:
  Rat   682 DMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVNMRK-IGSSRGMVSAYPRQLESLIRLAEAHAK 745

  Fly   619 LRLSDSVEKDDVAEALRLLEMSKDSLNQ 646
            :|.||.||..||.||.||   .:::|.|
  Rat   746 VRFSDKVEAIDVEEAKRL---HREALKQ 770

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm7	NP_523984.1	MCM_N	13..97	CDD:379644	13/80 (16%)
		MCM	145..641	CDD:214631	199/523 (38%)
Mcm4	NP_387500.1	MCM_N	165..286	CDD:291233	25/126 (20%)
		MCM	266..769	CDD:214631	199/527 (38%)
		P-loop_NTPase	504..643	CDD:304359	88/138 (64%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820