DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm7 and Mcm6

DIOPT Version :9

Sequence 1:	NP_523984.1	Gene:	Mcm7 / 39014	FlyBaseID:	FBgn0020633	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_058983.1	Gene:	Mcm6 / 29685	RGDID:	61967	Length:	821	Species:	Rattus norvegicus

Alignment Length:	734	Identity:	243/734 - (33%)
Similarity:	359/734 - (48%)	Gaps:	140/734 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 FLSEFCKCDDDGKKEFV-YGSQLVKLAHREQVLITIDLDDLAEFNESLAEAVVDN--------CR 71
            ||.||  ...||:.::: :..:|::   .|:..:.:...||.:||:.|:..:.:.        ||
  Rat    33 FLEEF--QGSDGEIKYLQFAEELIR---PERNTLVVSFADLEQFNQQLSTTIQEEFYRVYPYLCR 92

  Fly    72 RYTSIFSDVIAELLPSYKQQEVHAKDALDVYIEHRLMMESRTRNPMEQRDERNSFPSELMKRFEV 136
                                      ||..:::                 :|...|  ..|.|.|
  Rat    93 --------------------------ALKTFVK-----------------DRKEIP--FAKDFYV 112

  Fly   137 GFKPLSTEKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRCGSETYQPVNSLSFT 201
            .|:.|.|.  |.|||:.:..||.|..:.|.|.|...|.|.:|..|:.|..|.:..........:|
  Rat   113 AFQDLPTR--HKIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLDCQTVIKDVEQQFKYT 175

  Fly   202 PVHDCPSDDCRVNKAGGRLYLQTRGSKFVKFQEVKMQEHSDQVPVGHIPRSMTIMCRGEVTRMAQ 266
            ....|.:..|...|   |..|.|..|:||.||:|::||...::|.|.||||:.::.|.|....||
  Rat   176 QPSICRNPVCANRK---RFLLDTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVVLRAEAVESAQ 237

  Fly   267 PGDHIVVSGVFL----------PLMRT----------GF-AQMIQGL--LSETFLQAHRIICI-- 306
            .||....:|..:          |..|.          |: .:.|:||  |....| ::|::.:
  Rat   238 AGDRCDFTGTLIVVPDVSKLSTPGARAETNSRVSGADGYETEGIRGLRALGVRDL-SYRLVFLAC 301

  Fly   307 ---NKNDEISDK---DAELTPEELE------------ELAQD-DFYERLATSLAPEIYGHLDVKK 352
               ..|.....|   |.|.|.|.::            |::|| :.|..|.|||.|.|:|:.:||:
  Rat   302 YVAPTNPRFGGKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKR 366

  Fly   353 ALLLLLVGGVDKRP-DGMKIRGNINICLMGDPGVAKSQLLGYISRLAVRSQYTTGRGSSGVGLTA 416
            .:||:|.|||.|.. :|..:||:||:|::|||..||||.|.::...:.|:.||:|:.||..||||
  Rat   367 GVLLMLFGGVPKTTGEGTSLRGDINVCIVGDPSTAKSQFLKHVDEFSPRAVYTSGKASSAAGLTA 431

  Fly   417 AVMKDPLTGEMTLEGGALVLADQGVCCIDEFDKMADQDRTAIHEVMEQQTISIAKAGIMTTLNAR 481
            ||::|..:.|..:|.|||:|||.|||||||||||..:|:.||||.||||||||.|||:..|||||
  Rat   432 AVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDMRDQVAIHEAMEQQTISITKAGVKATLNAR 496

  Fly   482 VSILAAANPAFGRYNPRRTVEQNIQLPAALLSRFDLLWLIQDKPDRDNDLRLAKHITYVHSHSKQ 546
            .||||||||..|.|:..::::|||.|.|.::|||||.:::.|:.:...|..:|:.|..:||..::
  Rat   497 TSILAAANPVSGHYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRIEE 561

  Fly   547 PPTRVKALDMNLMRRYINLCKRKNPTIPDELTDYIVGAYVELRREARNQKDMTFTS----ARNLL 607
            ...||.:||.  :|||:...::..|.|..|..|:||..|..||:  |:...:|.:|    .|.|.
  Rat   562 SIDRVYSLDD--IRRYLLFARQFKPKISKESEDFIVEQYKRLRQ--RDGSGITKSSWRITVRQLE 622

  Fly   608 GILRLSTALARLRLSDSVEKDDVAEALRLL-------EMSKDSLNQIHEHQ----------KGHV 655
            .::|||.::||:...|.|:...|.||.|||       |....:|:|..|.|          .||.
  Rat   623 SMIRLSESMARMHCCDEVQPKHVKEAFRLLNKSIIRVETPDVNLDQEEEIQMETDEGPGGINGHA 687

  Fly   656 PNTSDRIFAIVRELAGSGK 674
            .:.     |.|....|||:
  Rat   688 DSP-----APVNGFNGSGE 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm7	NP_523984.1	MCM_N	13..97	CDD:379644	15/89 (17%)
Mcm7	NP_523984.1	MCM	145..641	CDD:214631	207/551 (38%)
Mcm6	NP_058983.1	MCM_N	27..114	CDD:405270	22/130 (17%)
		MCM	119..657	CDD:214631	207/547 (38%)
		MCM6_C	711..817	CDD:408078
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820