DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm7 and Mcm8

DIOPT Version :9

Sequence 1:	NP_523984.1	Gene:	Mcm7 / 39014	FlyBaseID:	FBgn0020633	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_001099984.1	Gene:	Mcm8 / 296178	RGDID:	1305218	Length:	830	Species:	Rattus norvegicus

Alignment Length:	729	Identity:	203/729 - (27%)
Similarity:	330/729 - (45%)	Gaps:	156/729 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 ITIDLDDLAEFNESLAEAVVDNCRRYTSIFSDVIAELLPSYKQQEVHAKDALDVYIE------HR 106
            |.:|..:|.:.||                    |..|:|..   |...:||.:..:.      |:
  Rat   111 ILVDFKELTKDNE--------------------ITNLIPDI---ENALRDAPEKTLACMGLAIHQ 152

  Fly   107 LMMESRTRNPMEQRDERN---------SFPSELMKRFEVGFKPLSTEKAHSIREVKAQHIGKLVT 162
            ::.:...|:..|.:.:..         :.|....:.:  .::||:     .::.::|...||.::
  Rat   153 VLTKDLERHAAELQAQEGLCNGGGTMVNVPHIYARVY--NYEPLT-----HLKNIRATCYGKYIS 210

  Fly   163 VRGIVTRCTEVKPMMVVATYTCDRCGSETYQPVNSLSFTPVHDCPSDDCRVNKAGGRLYLQTRGS 227
            :||.|.|.:.:||:.....:.|..||.....|:....:.....||...||     ||.:...|.|
  Rat   211 IRGTVVRVSNIKPLCTKMAFQCAACGEIQSFPLPDGKYNLPTKCPVPACR-----GRSFTPLRSS 270

  Fly   228 KF---VKFQEVKMQE-HSD-QVPVGHIPRSMTIMCR--GEVTRMAQPGDHIVVSGV--------- 276
            ..   :.:|.:|:|| .|| |...|.|||  ||.|.  .::.....|||.:.|:|:
  Rat   271 PLTVTMDWQLIKIQELMSDAQREAGRIPR--TIECELVHDLVDSCVPGDTVTVTGIVKVSNSEEG 333

  Fly   277 ---------FLPLMRTGFAQMIQGLLSETFLQAHRIICINKNDEISDKDAELTPEELEEL----- 327
                     ||..:........:|..::|             .|...|...|....|::|
  Rat   334 SRSKNDKCMFLLYIEANSVSNSKGQKAQT-------------AEDGCKHGTLMEFSLKDLYAIQE 385

  Fly   328 --AQDDFYERLATSLAPEIYGHLDVKKALLLLLVGGVDKRPDG---MKIRGNINICLMGDPGVAK 387
              |:::..:.:..||.|.|:||..||..|:|.|.||..|..|.   :.|||:.::.::||||:.|
  Rat   386 IQAEENLLKLIVNSLCPVIFGHELVKAGLMLALFGGSQKYADDKNRIPIRGDPHVLIVGDPGLGK 450

  Fly   388 SQLLGYISRLAVRSQYTTGRGSSGVGLTAAVMKDPLTGEMTLEGGALVLADQGVCCIDEFDKMAD 452
            ||:|.....:|.|..|..|..::..|||..:.||..:|:..||.|||||.|||:|.|||||||.:
  Rat   451 SQMLQAACNVAPRGVYVCGNTATSSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGN 515

  Fly   453 QDRTAIHEVMEQQTISIAKAGIMTTLNARVSILAAANPAFGRYNPRRTVEQNIQLPAALLSRFDL 517
            |.: |:.|.||||:||:||||::.:|.||.||:|||||..|.||..|||.:|:::.:||||||||
  Rat   516 QHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKARTVSENLKMGSALLSRFDL 579

  Fly   518 LWLIQDKPDRDNDLRLAKHITYVHSH-----SKQPPTRVKALDMN-------------------- 557
            ::::.|.|:..:|..|::|:..:.:.     |....:||.:.|.|
  Rat   580 VFILLDTPNEQHDHLLSEHVIAIRAGKQRAVSSATVSRVLSQDSNTSVLEVVSEKPLSERLKVAP 644

  Fly   558 ----------LMRRYINLCKR-KNPTIPDELTDYIVGAYVELRREARNQKDMTFTSARNLLGILR 611
                      |:|:||...:: .:|.:..|....:...|:|||::::.......|: |.|..::|
  Rat   645 GEKTDPIPHQLLRKYIGYARQYVHPRLSTEAAQALQDFYLELRKQSQRVGSSPITT-RQLESLIR 708

  Fly   612 LSTALARLRLSDSVEKDDVAEALRLLEMSKDSLNQIHEHQKGHVPNTSDRIFAIVRELAGSGKAV 676
            |:.|.|||.|.:...|:|..:   ::|:.|.|:...:..:.|::.        ..|...|||
  Rat   709 LTEARARLELREEATKEDAED---IIEIMKHSMLGTYSDEFGNLD--------FERSQHGSG--- 759

  Fly   677 KISDIMDRCTTKGF 690
                :.:|.|.|.|
  Rat   760 ----MSNRSTAKRF 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm7	NP_523984.1	MCM_N	13..97	CDD:379644	9/48 (19%)
Mcm7	NP_523984.1	MCM	145..641	CDD:214631	175/566 (31%)
Mcm8	NP_001099984.1	MCM_N	88..213	CDD:291233	20/131 (15%)
		Mcm2	129..827	CDD:224162	196/691 (28%)
		AAA	425..583	CDD:99707	78/158 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820