DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm7 and Mcm5

DIOPT Version :9

Sequence 1:	NP_523984.1	Gene:	Mcm7 / 39014	FlyBaseID:	FBgn0020633	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	XP_038953490.1	Gene:	Mcm5 / 291885	RGDID:	1306616	Length:	734	Species:	Rattus norvegicus

Alignment Length:	749	Identity:	228/749 - (30%)
Similarity:	376/749 - (50%)	Gaps:	113/749 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ARRDYAQDRESIKTFLSEFCKCDDDGKKEFVYGSQLVKLAHREQVLITIDLDDLAEFNESLAEAV 66
            ||:.:.|.|  .|.||.::....|.....|.|..:|.:..:..:..|.::::|||.|:|.||:.:
  Rat    26 ARKSHLQKR--FKEFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWIEVEMEDLASFDEELADYL 88

  Fly    67 VDNCRRYTSIFSDVIAELLPSYKQQEVHAKDALDVYIEHRLMMESRTRNPMEQRDERNSFPSELM 131
                                 |||.           .||..::|...:...::.........||:
  Rat    89 ---------------------YKQP-----------AEHLQLLEEAAKEVADEVTRPRPAGDELL 121

  Fly   132 KRFEVGFKPLSTEKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRCGSETYQPVN 196
            :..:|..|  |.....|||.:|:..:..||.:.||:...:.|:......:..|..|    :..:.
  Rat   122 QDIQVMLK--SDASPSSIRILKSDMMSHLVKIPGIIISASAVRAKATRISIQCRSC----HNTLT 180

  Fly   197 SLSFTP---VHDCPSDDCRVNKAG------GRLYLQTRGSKFVKFQEVKMQEHSDQVPVGHIPRS 252
            :::..|   .:..|. .|.:::||      ...::.....|.|.||.:|:||..|.||.|.:||.
  Rat   181 NIAMRPGLEGYALPR-KCNMDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRH 244

  Fly   253 MTIMCRGEVTRMAQPGDHIVVSGVFLPLMRTGF------AQMIQGLLSETFLQAHRIICINKNDE 311
            |.:.|...:.....||:.:.:.|:: .:.:.|.      .::..|:.|...    |::.|..:.:
  Rat   245 MQLYCDRYLCDKVVPGNRVTIMGIY-SIKKFGMNPSKGRDRVGVGIRSSYI----RVLGIQVDTD 304

  Fly   312 ISDKD--AELTPEELEEL----AQDDFYERLATSLAPEIYGHLDVKKALLLLLVGGVDKR-PDGM 369
            .|.:.  ..::|:|.||.    |..:.||.::.|::|.|:|.:|:|||:..||.||..|| |||:
  Rat   305 GSGRSFAGSVSPQEEEEFRRLAALPNIYELVSRSVSPSIFGGMDMKKAIACLLFGGSRKRLPDGL 369

  Fly   370 KIRGNINICLMGDPGVAKSQLLGYISRLAVRSQYTTGRGSSGVGLTAAVMKDPLTGEMTLEGGAL 434
            ..||:||:.::||||.||||||.::.:.:....||:|:|||..||||:|::||.:....:||||:
  Rat   370 TRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLTASVIRDPSSRNFIMEGGAM 434

  Fly   435 VLADQGVCCIDEFDKMADQDRTAIHEVMEQQTISIAKAGIMTTLNARVSILAAANPAFGRYNPRR 499
            ||||.||.||||||||.:.||.||||.|||||||||||||.||||:|.|:|||||..|||::..:
  Rat   435 VLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDETK 499

  Fly   500 TVEQNIQLPAALLSRFDLLWLIQDKPDRDNDLRLAKHITYVHSHSKQPPTRVKA-LDMNLMRRYI 563
            . |.||.....:|||||::::::|:.:.:.|:.||||:..:|..:......|:. :|:..|:::|
  Rat   500 G-EDNIDFMPTILSRFDMIFIVKDEHNEERDMMLAKHVITLHVSALTQTQAVEGEIDLAKMKKFI 563

  Fly   564 NLCK-RKNPTIPDELTDYIVGAYVELRREAR-NQKDMTFTSA-----RNLLGILRLSTALARLRL 621
            ..|: |..|.:..|..:.:...|:.:|..|| :::|:...|:     |.|..|:|::.||::::|
  Rat   564 AYCRARCGPRLSAEAAEKLKNRYIIMRSGARQHERDIDRRSSIPITVRQLEAIVRIAEALSKMKL 628

  Fly   622 SDSVEKDDVAEALRLLEMS---------------------KDSLNQIHEHQKGHVPNTSDRIFAI 665
            .....:.||.|||||.::|                     ::.|::|.:..|        |.|||
  Rat   629 QPFATEADVEEALRLFQVSTLDAALSGNLSGVEGFTTQEDQEMLSRIEKQLK--------RRFAI 685

  Fly   666 VRELAGSGKAVKISDIMDRCTTKGFKPDQVDKCI 699
                   |..|....|:...|.:.:....:.|.:
  Rat   686 -------GSQVSEHSIVQDFTKQKYPEHAIRKVL 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm7	NP_523984.1	MCM_N	13..97	CDD:379644	18/83 (22%)
Mcm7	NP_523984.1	MCM	145..641	CDD:214631	186/546 (34%)
Mcm5	XP_038953490.1	MCM_N	32..129	CDD:405270	26/130 (20%)
Mcm5	XP_038953490.1	MCM	133..649	CDD:214631	186/526 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820