DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm7 and mcm7

DIOPT Version :9

Sequence 1:	NP_523984.1	Gene:	Mcm7 / 39014	FlyBaseID:	FBgn0020633	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_997734.1	Gene:	mcm7 / 192333	ZFINID:	ZDB-GENE-020419-27	Length:	721	Species:	Danio rerio

Alignment Length:	722	Identity:	489/722 - (67%)
Similarity:	585/722 - (81%)	Gaps:	3/722 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MARRDYAQDRESIKTFLSEFCKCDDDGKKEFVYGSQLVKLAHREQVLITIDLDDLAEFNESLAEA 65
            ||.:||..::|..|.||.||...||.|||.|.||:|||.|||||||.:.:||||:||.:..|.|:
Zfish     1 MAPKDYTAEKEKCKRFLQEFYTEDDSGKKIFKYGAQLVSLAHREQVALLVDLDDVAEEDPDLVES 65

  Fly    66 VVDNCRRYTSIFSDVIAELLPSYKQQEVHAKDALDVYIEHRLMMESRTRNPMEQRDERNSFPSEL 130
            |.:|.:|||::|:|.|.||||.|:::|...|||||||||||||||.|.|:|.:.||.|..:|.||
Zfish    66 VCENAKRYTALFADAIHELLPEYREREAVVKDALDVYIEHRLMMEVRGRDPADTRDHRKQYPPEL 130

  Fly   131 MKRFEVGFKPLSTEKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRCGSETYQPV 195
            |:||||.|:|.:|.|...:|:|||..||:||||||||||.|||||||.|||||||:||:|||||:
Zfish   131 MRRFEVYFRPPATLKPRVVRDVKADSIGQLVTVRGIVTRATEVKPMMAVATYTCDQCGAETYQPI 195

  Fly   196 NSLSFTPVHDCPSDDCRVNKAGGRLYLQTRGSKFVKFQEVKMQEHSDQVPVGHIPRSMTIMCRGE 260
            .|.||||:..|||.:|..||:|||||||||||||:||||:::||||||||||:|||||||..|||
Zfish   196 ASPSFTPLIMCPSQECVTNKSGGRLYLQTRGSKFIKFQELRIQEHSDQVPVGNIPRSMTIYARGE 260

  Fly   261 VTRMAQPGDHIVVSGVFLPLMRTGFAQMIQGLLSETFLQAHRIICINKNDEISDKDAELTPEELE 325
            .||:||||||:.||||||||:|:||.|.:|||||||:|:.|.|..:||.::......||:.|||.
Zfish   261 NTRVAQPGDHVAVSGVFLPLLRSGFRQAVQGLLSETYLECHSITLMNKTEDDELGTEELSDEELR 325

  Fly   326 ELAQDDFYERLATSLAPEIYGHLDVKKALLLLLVGGVDKRPDGMKIRGNINICLMGDPGVAKSQL 390
            ::.::||||:||.|:|||||||.||||||||||||||::.|.|||||||||||||||||||||||
Zfish   326 QITEEDFYEKLAGSIAPEIYGHEDVKKALLLLLVGGVEQAPRGMKIRGNINICLMGDPGVAKSQL 390

  Fly   391 LGYISRLAVRSQYTTGRGSSGVGLTAAVMKDPLTGEMTLEGGALVLADQGVCCIDEFDKMADQDR 455
            |.||.|||.||||||||||||||||||||:||:|||||||||||||||.|||||||||||||.||
Zfish   391 LSYIDRLAPRSQYTTGRGSSGVGLTAAVMRDPVTGEMTLEGGALVLADLGVCCIDEFDKMADADR 455

  Fly   456 TAIHEVMEQQTISIAKAGIMTTLNARVSILAAANPAFGRYNPRRTVEQNIQLPAALLSRFDLLWL 520
            |||||||||||||||||||||:||||.|||||||||:||||||:::|||||||||||||||||||
Zfish   456 TAIHEVMEQQTISIAKAGIMTSLNARCSILAAANPAYGRYNPRKSIEQNIQLPAALLSRFDLLWL 520

  Fly   521 IQDKPDRDNDLRLAKHITYVHSHSKQPPTRVKALDMNLMRRYINLCKRKNPTIPDELTDYIVGAY 585
            |||:||.::|||||:||||||.|.:||||....:||.||||||:.||:|.|.:|:.|:|||..||
Zfish   521 IQDRPDAESDLRLAQHITYVHQHCRQPPTHFTPIDMKLMRRYISKCKQKQPVVPESLSDYITAAY 585

  Fly   586 VELRREARNQKDMTFTSARNLLGILRLSTALARLRLSDSVEKDDVAEALRLLEMSKDSLNQIHEH 650
            ||:|:|||..||.||||||.||.||||||||||||:...|||:||.||:||:||||||| |....
Zfish   586 VEMRKEARVSKDTTFTSARTLLSILRLSTALARLRMVSVVEKEDVNEAMRLMEMSKDSL-QADRS 649

  Fly   651 QKGHVPNTSDRIFAIVRELAG--SGKAVKISDIMDRCTTKGFKPDQVDKCIDDYEELNVWQVNMG 713
            ........:|.||:::|||.|  :|::|::|....||.::||.|.|....:.:||||||||:|..
Zfish   650 SSSRAQRPADVIFSLLRELCGESAGRSVRVSAAEQRCVSRGFTPAQFQAALQEYEELNVWQINQA 714

  Fly   714 RTKITFM 720
            ||:|||:
Zfish   715 RTRITFV 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm7	NP_523984.1	MCM_N	13..97	CDD:379644	45/83 (54%)
Mcm7	NP_523984.1	MCM	145..641	CDD:214631	371/495 (75%)
mcm7	NP_997734.1	MCM_N	14..93	CDD:317013	44/78 (56%)
mcm7	NP_997734.1	MCM_OB	145..641	CDD:330264	371/495 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	257	1.000	Domainoid score	I1985
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4323
Inparanoid	1	1.050	725	1.000	Inparanoid score	I611
OMA	1	1.010	-	-		QHG54225
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	1	1.000	-	-		FOG0003915
OrthoInspector	1	1.000	-	-		oto41184
orthoMCL	1	0.900	-	-		OOG6_102101
Panther	1	1.100	-	-	LDO	PTHR11630
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3219
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.980