DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm7 and Mcm6

DIOPT Version :9

Sequence 1:	NP_523984.1	Gene:	Mcm7 / 39014	FlyBaseID:	FBgn0020633	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_032593.1	Gene:	Mcm6 / 17219	MGIID:	1298227	Length:	821	Species:	Mus musculus

Alignment Length:	683	Identity:	234/683 - (34%)
Similarity:	347/683 - (50%)	Gaps:	118/683 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 FLSEFCKCDDDGKKEFV-YGSQLVKLAHREQVLITIDLDDLAEFNESLAEAVVDN--------CR 71
            ||.||  ...||:.::: :..:|::   .|:..:.:...||.:||:.|:..:.:.        ||
Mouse    33 FLEEF--QGSDGEIKYLQFAEELIR---PERNTLVVSFADLEQFNQQLSTTIQEEFYRVYPYLCR 92

  Fly    72 RYTSIFSDVIAELLPSYKQQEVHAKDALDVYIEHRLMMESRTRNPMEQRDERNSFPSELMKRFEV 136
                                      ||..:::                 :|...|  ..|.|.|
Mouse    93 --------------------------ALKTFVK-----------------DRKEIP--FAKDFYV 112

  Fly   137 GFKPLSTEKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRCGSETYQPVNSLSFT 201
            .|:.|.|.  |.|||:.:..||.|..:.|.|.|...|.|.:|..|:.|..|.:..........:|
Mouse   113 AFQDLPTR--HKIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLDCQTVIKDVEQQFKYT 175

  Fly   202 PVHDCPSDDCRVNKAGGRLYLQTRGSKFVKFQEVKMQEHSDQVPVGHIPRSMTIMCRGEVTRMAQ 266
            ..:.|.:..|...|   |..|.|..|:||.||:|::||...::|.|.||||:.::.|.|....||
Mouse   176 QPNICRNPVCANRK---RFLLDTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQ 237

  Fly   267 PGDHIVVSGVFL----------PLMRT----------GF-AQMIQGL-------LSE--TFLQAH 301
            .||....:|..:          |..|.          |: .:.|:||       ||.  .||..|
Mouse   238 AGDRCDFTGALIVVPDVSKLSTPGARAETNSRVSGADGYETEGIRGLRALGVRDLSYRLVFLACH 302

  Fly   302 RIICINK---NDEISDKDA-------ELTPEELE---ELAQD-DFYERLATSLAPEIYGHLDVKK 352
             :...|.   ..|:.|::.       ::|.:|.|   |::|| :.|..|.|||.|.|:|:.:||:
Mouse   303 -VAPTNPRFGGKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKR 366

  Fly   353 ALLLLLVGGVDKRP-DGMKIRGNINICLMGDPGVAKSQLLGYISRLAVRSQYTTGRGSSGVGLTA 416
            .:||:|.|||.|.. :|..:||:||:|::|||..||||.|.::...:.|:.||:|:.||..||||
Mouse   367 GVLLMLFGGVPKTTGEGTSLRGDINVCIVGDPSTAKSQFLKHVDEFSPRAVYTSGKASSAAGLTA 431

  Fly   417 AVMKDPLTGEMTLEGGALVLADQGVCCIDEFDKMADQDRTAIHEVMEQQTISIAKAGIMTTLNAR 481
            ||::|..:.|..:|.|||:|||.|||||||||||..:|:.||||.||||||||.|||:..|||||
Mouse   432 AVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDMRDQVAIHEAMEQQTISITKAGVKATLNAR 496

  Fly   482 VSILAAANPAFGRYNPRRTVEQNIQLPAALLSRFDLLWLIQDKPDRDNDLRLAKHITYVHSHSKQ 546
            .||||||||..|.|:..::::|||.|.|.::|||||.:::.|:.:...|..:|:.|..:||..::
Mouse   497 TSILAAANPVSGHYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRIEE 561

  Fly   547 PPTRVKALDMNLMRRYINLCKRKNPTIPDELTDYIVGAYVELRREARNQKDMTFTS----ARNLL 607
            ...||.:||.  :|||:...::..|.|..|..|:||..|..||:  |:...:|.:|    .|.|.
Mouse   562 SIDRVYSLDD--IRRYLLFARQFKPKISKESEDFIVEQYKRLRQ--RDGSGVTKSSWRITVRQLE 622

  Fly   608 GILRLSTALARLRLSDSVEKDDVAEALRLLEMS 640
            .::|||.::||:...|.|:...|.||.|||..|
Mouse   623 SMIRLSESMARMHCCDEVQPKHVKEAFRLLNKS 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm7	NP_523984.1	MCM_N	13..97	CDD:379644	15/89 (17%)
Mcm7	NP_523984.1	MCM	145..641	CDD:214631	209/545 (38%)
Mcm6	NP_032593.1	MCM_N	29..139	CDD:291233	32/157 (20%)
		MCM	119..657	CDD:214631	210/547 (38%)
		P-loop_NTPase	<447..534	CDD:304359	58/86 (67%)
		Arginine finger	528..531		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	676..708
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820