DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm7 and Mcm5

DIOPT Version :9

Sequence 1:	NP_523984.1	Gene:	Mcm7 / 39014	FlyBaseID:	FBgn0020633	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_001289469.1	Gene:	Mcm5 / 17218	MGIID:	103197	Length:	734	Species:	Mus musculus

Alignment Length:	749	Identity:	227/749 - (30%)
Similarity:	374/749 - (49%)	Gaps:	113/749 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ARRDYAQDRESIKTFLSEFCKCDDDGKKEFVYGSQLVKLAHREQVLITIDLDDLAEFNESLAEAV 66
            ||:...|.|  .|.||.::....|.....|.|..:|.:..:..:..|.::::|||.|:|.||:
Mouse    26 ARKSQLQRR--FKEFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWIEVEMEDLASFDEELAD-- 86

  Fly    67 VDNCRRYTSIFSDVIAELLPSYKQQEVHAKDALDVYIEHRLMMESRTRNPMEQRDERNSFPSELM 131
                                     .:|.:.|     ||..::|...:...::.........||:
Mouse    87 -------------------------HLHKQPA-----EHLQLLEEAAKEVADEVTRPRPAGDELL 121

  Fly   132 KRFEVGFKPLSTEKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRCGSETYQPVN 196
            :..:|..|  |.....|||.:|:..:..||.:.||:...:.|:......:..|..|    :..:.
Mouse   122 QDIQVMLK--SDASPSSIRILKSDMMSHLVKIPGIIISASAVRAKATRISIQCRSC----HNTLT 180

  Fly   197 SLSFTP---VHDCPSDDCRVNKAG------GRLYLQTRGSKFVKFQEVKMQEHSDQVPVGHIPRS 252
            :::..|   .:..|. .|.:::||      ...::.....|.|.||.:|:||..|.||.|.:||.
Mouse   181 NIAMRPGLEGYALPR-KCNMDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRH 244

  Fly   253 MTIMCRGEVTRMAQPGDHIVVSGVFLPLMRTGF------AQMIQGLLSETFLQAHRIICINKNDE 311
            |.:.|...:.....||:.:.:.|:: .:.:.|.      .::..|:.|...    |::.|..:.:
Mouse   245 MQLYCDRYLCDKVVPGNRVTIMGIY-SIKKFGLNPSKGRDRVGVGIRSSYI----RVLGIQVDTD 304

  Fly   312 ISDKD--AELTPEELEEL----AQDDFYERLATSLAPEIYGHLDVKKALLLLLVGGVDKR-PDGM 369
            .|.:.  ..::|:|.||.    |..:.||.::.|::|.|:|.:|:|||:..||.||..|| |||:
Mouse   305 GSGRSFAGSVSPQEEEEFRRLAALPNIYELISKSISPSIFGGMDMKKAIACLLFGGSRKRLPDGL 369

  Fly   370 KIRGNINICLMGDPGVAKSQLLGYISRLAVRSQYTTGRGSSGVGLTAAVMKDPLTGEMTLEGGAL 434
            ..||:||:.::||||.||||||.::.:.:....||:|:|||..||||:|::||.:....:||||:
Mouse   370 TRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLTASVIRDPSSRNFIMEGGAM 434

  Fly   435 VLADQGVCCIDEFDKMADQDRTAIHEVMEQQTISIAKAGIMTTLNARVSILAAANPAFGRYNPRR 499
            ||||.||.||||||||.:.||.||||.|||||||||||||.||||:|.|:|||||..|||::..:
Mouse   435 VLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDETK 499

  Fly   500 TVEQNIQLPAALLSRFDLLWLIQDKPDRDNDLRLAKHITYVHSHSKQPPTRVKA-LDMNLMRRYI 563
            . |.||.....:|||||::::::|:.:.:.|:.||||:..:|..:......|:. :|:..|:::|
Mouse   500 G-EDNIDFMPTILSRFDMIFIVKDEHNEERDMMLAKHVMTLHVSALTQTQAVEGEIDLAKMKKFI 563

  Fly   564 NLCK-RKNPTIPDELTDYIVGAYVELRREAR-NQKDMTFTSA-----RNLLGILRLSTALARLRL 621
            ..|: |..|.:..|..:.:...|:.:|..|| :::|....|:     |.|..|:|::.||::::|
Mouse   564 AYCRARCGPRLSAEAAEKLKNRYIIMRSGARQHERDSDRRSSIPITVRQLEAIVRIAEALSKMKL 628

  Fly   622 SDSVEKDDVAEALRLLEMS---------------------KDSLNQIHEHQKGHVPNTSDRIFAI 665
            .....:.||.|||||.::|                     ::.|::|.:..|        |.|||
Mouse   629 QPFATEADVEEALRLFQVSTLDAALSGNLSGVEGFTTQEDQEMLSRIEKQLK--------RRFAI 685

  Fly   666 VRELAGSGKAVKISDIMDRCTTKGFKPDQVDKCI 699
                   |..|....|:...|.:.:....:.|.:
Mouse   686 -------GSQVSEHSIVQDFTKQKYPEHAIRKVL 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm7	NP_523984.1	MCM_N	13..97	CDD:379644	16/83 (19%)
Mcm7	NP_523984.1	MCM	145..641	CDD:214631	186/546 (34%)
Mcm5	NP_001289469.1	MCM_N	35..130	CDD:379644	24/128 (19%)
		MCM	133..649	CDD:214631	186/526 (35%)
		Arginine finger	512..515		2/2 (100%)
		BREX_BrxC	<618..>730	CDD:380283	24/110 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820