Protein Alignment Mcm7 and Mcm4

DIOPT Version :10

• Sequence 1: NP_523984.1
• Gene: Mcm7 / 39014
• FlyBaseID: FBgn0020633
• Length: 720
• Species: Drosophila melanogaster
• Sequence 2: NP_032591.3
• Gene: Mcm4 / 17217
• MGIID: 103199
• Length: 862
• Species: Mus musculus
• Alignment Length: 667
• Identity: 228/667 - (34%)
• Similarity: 351/667 - (52%)
• Gaps: 88/667 - (13%)

  Fly    48 ITIDL-------DDLAEFNESLAEAVV------------DNCRRYTSIFSDVIAE---------L 84
            :.:||       :|:....:||.:.:|            :|.:|:...|:|.:|:         .
Mouse   124 LQVDLQSDGAAAEDIVPSEQSLGQKLVIWGTDVNVATCKENFQRFLQCFTDPLAKEEENVGIDIT 188

  Fly    85 LPSYKQQ----EVHAKDALDVYIEHRLMMESRTRNPMEQRDERNSFPSELMKRF----------- 134
            .|.|.||    .:..:..|:|..||   ::|.::|...|   ..|:|.|::..|
Mouse   189 QPLYMQQLGEINITGEPFLNVNCEH---IKSFSKNLYRQ---LISYPQEVIPTFDMAVNEIFFDR 247

  Fly   135 --------EVGFKPLSTEKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRCGSET 191
                    ::..:|.:..|..|:|.:..:.|.:|:|:.|:|.|.:::.|.|..|.:.|..|...|
Mouse   248 YPDSILEHQIQVRPFNALKTKSMRNLNPEDIDQLITISGMVIRTSQLIPEMQEAFFQCQVCAHTT 312

  Fly   192 YQPVNSLSFTPVHDCPSDDCRVNKAGGRLYLQTRGSKFVKFQEVKMQEHSDQVPVGHIPRSMTIM 256
            ...::....  ...|....|....:   :.|....|.|...|.:|:||..:.:|.|..|.::.:.
Mouse   313 RVEIDRGRI--AEPCSCVHCHTTHS---MALIHNRSFFSDKQMIKLQESPEDMPAGQTPHTIVLF 372

  Fly   257 CRGEVTRMAQPGDHIVVSGVF--LPLMRTGFAQMIQGLLSETFLQAHRIICINKNDEIS----DK 315
            ...::....||||.:.|:|::  :|:........::.:. :|.:.   :|...|.|...    |:
Mouse   373 AHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKSVY-KTHID---VIHYRKTDAKRLHGLDE 433

  Fly   316 DAE--LTPEE----LEELA-QDDFYERLATSLAPEIYGHLDVKKALLLLLVGGVDK---RPDGMK 370
            :||  |..|:    |:||: :.|.|||||::|||.||.|.|:||.:||.|.||..|   .....|
Mouse   434 EAEQKLFSEKRVKLLKELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGK 498

  Fly   371 IRGNINICLMGDPGVAKSQLLGYISRLAVRSQYTTGRGSSGVGLTAAVMKDPLTGEMTLEGGALV 435
            .|..|||.|.||||.:|||||.|:..|..|.|||:|:|||.|||||.|||||.|.::.|:.||||
Mouse   499 FRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALV 563

  Fly   436 LADQGVCCIDEFDKMADQDRTAIHEVMEQQTISIAKAGIMTTLNARVSILAAANPAFGRYNPRRT 500
            |:|.|:|||||||||.:..|:.:||||||||:|||||||:..||||.|:||||||...::||::|
Mouse   564 LSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKKT 628

  Fly   501 VEQNIQLPAALLSRFDLLWLIQDKPDRDNDLRLAKHITYVHSHSKQPPTRVKALDMNLMRRYINL 565
            ..:|||||..|||||||::|:.|..|...|.|||.|:..::..|:: ....:.|||.:::.||..
Mouse   629 TIENIQLPHTLLSRFDLIFLMLDPQDEAYDRRLAHHLVSLYYQSEE-QVEEEFLDMAVLKDYIAY 692

  Fly   566 CKRK-NPTIPDELTDYIVGAYVELRREARNQKDMTFTSARNLLGILRLSTALARLRLSDSVEKDD 629
            .... .|.:.:|.:..::.|||.:|: ..:.:.|.....|.|..::||:.|.|::|.|:.||..|
Mouse   693 AHSTIMPRLSEEASQALIEAYVNMRK-IGSSRGMVSAYPRQLESLIRLAEAHAKVRFSNKVEAID 756

  Fly   630 VAEALRLLEMSKDSLNQ 646
            |.||.||   .:::|.|
Mouse   757 VEEAKRL---HREALKQ 770

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm7	NP_523984.1	MCM_N	10..103	CDD:464206	17/86 (20%)
		MCM	145..641	CDD:475121	199/512 (39%)
Mcm4	NP_032591.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	90..121
		MCM_N	162..263	CDD:464206	21/106 (20%)
		MCM	266..769	CDD:214631	199/516 (39%)
		Arginine finger	641..644		2/2 (100%)