DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm7 and Mcm4

DIOPT Version :9

Sequence 1:	NP_523984.1	Gene:	Mcm7 / 39014	FlyBaseID:	FBgn0020633	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_032591.3	Gene:	Mcm4 / 17217	MGIID:	103199	Length:	862	Species:	Mus musculus

Alignment Length:	667	Identity:	228/667 - (34%)
Similarity:	351/667 - (52%)	Gaps:	88/667 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 ITIDL-------DDLAEFNESLAEAVV------------DNCRRYTSIFSDVIAE---------L 84
            :.:||       :|:....:||.:.:|            :|.:|:...|:|.:|:         .
Mouse   124 LQVDLQSDGAAAEDIVPSEQSLGQKLVIWGTDVNVATCKENFQRFLQCFTDPLAKEEENVGIDIT 188

  Fly    85 LPSYKQQ----EVHAKDALDVYIEHRLMMESRTRNPMEQRDERNSFPSELMKRF----------- 134
            .|.|.||    .:..:..|:|..||   ::|.::|...|   ..|:|.|::..|
Mouse   189 QPLYMQQLGEINITGEPFLNVNCEH---IKSFSKNLYRQ---LISYPQEVIPTFDMAVNEIFFDR 247

  Fly   135 --------EVGFKPLSTEKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRCGSET 191
                    ::..:|.:..|..|:|.:..:.|.:|:|:.|:|.|.:::.|.|..|.:.|..|...|
Mouse   248 YPDSILEHQIQVRPFNALKTKSMRNLNPEDIDQLITISGMVIRTSQLIPEMQEAFFQCQVCAHTT 312

  Fly   192 YQPVNSLSFTPVHDCPSDDCRVNKAGGRLYLQTRGSKFVKFQEVKMQEHSDQVPVGHIPRSMTIM 256
            ...::....  ...|....|....:   :.|....|.|...|.:|:||..:.:|.|..|.::.:.
Mouse   313 RVEIDRGRI--AEPCSCVHCHTTHS---MALIHNRSFFSDKQMIKLQESPEDMPAGQTPHTIVLF 372

  Fly   257 CRGEVTRMAQPGDHIVVSGVF--LPLMRTGFAQMIQGLLSETFLQAHRIICINKNDEIS----DK 315
            ...::....||||.:.|:|::  :|:........::.:. :|.:.   :|...|.|...    |:
Mouse   373 AHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKSVY-KTHID---VIHYRKTDAKRLHGLDE 433

  Fly   316 DAE--LTPEE----LEELA-QDDFYERLATSLAPEIYGHLDVKKALLLLLVGGVDK---RPDGMK 370
            :||  |..|:    |:||: :.|.|||||::|||.||.|.|:||.:||.|.||..|   .....|
Mouse   434 EAEQKLFSEKRVKLLKELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGK 498

  Fly   371 IRGNINICLMGDPGVAKSQLLGYISRLAVRSQYTTGRGSSGVGLTAAVMKDPLTGEMTLEGGALV 435
            .|..|||.|.||||.:|||||.|:..|..|.|||:|:|||.|||||.|||||.|.::.|:.||||
Mouse   499 FRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALV 563

  Fly   436 LADQGVCCIDEFDKMADQDRTAIHEVMEQQTISIAKAGIMTTLNARVSILAAANPAFGRYNPRRT 500
            |:|.|:|||||||||.:..|:.:||||||||:|||||||:..||||.|:||||||...::||::|
Mouse   564 LSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKKT 628

  Fly   501 VEQNIQLPAALLSRFDLLWLIQDKPDRDNDLRLAKHITYVHSHSKQPPTRVKALDMNLMRRYINL 565
            ..:|||||..|||||||::|:.|..|...|.|||.|:..::..|:: ....:.|||.:::.||..
Mouse   629 TIENIQLPHTLLSRFDLIFLMLDPQDEAYDRRLAHHLVSLYYQSEE-QVEEEFLDMAVLKDYIAY 692

  Fly   566 CKRK-NPTIPDELTDYIVGAYVELRREARNQKDMTFTSARNLLGILRLSTALARLRLSDSVEKDD 629
            .... .|.:.:|.:..::.|||.:|: ..:.:.|.....|.|..::||:.|.|::|.|:.||..|
Mouse   693 AHSTIMPRLSEEASQALIEAYVNMRK-IGSSRGMVSAYPRQLESLIRLAEAHAKVRFSNKVEAID 756

  Fly   630 VAEALRLLEMSKDSLNQ 646
            |.||.||   .:::|.|
Mouse   757 VEEAKRL---HREALKQ 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm7	NP_523984.1	MCM_N	13..97	CDD:379644	15/80 (19%)
Mcm7	NP_523984.1	MCM	145..641	CDD:214631	199/512 (39%)
Mcm4	NP_032591.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..71
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..121
		MCM_N	165..286	CDD:291233	26/126 (21%)
		MCM	266..769	CDD:214631	199/516 (39%)
		P-loop_NTPase	504..643	CDD:304359	88/138 (64%)
		Arginine finger	641..644		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820