Protein Alignment Mcm7 and Mcm2

DIOPT Version :10

• Sequence 1: NP_523984.1
• Gene: Mcm7 / 39014
• FlyBaseID: FBgn0020633
• Length: 720
• Species: Drosophila melanogaster
• Sequence 2: NP_032590.2
• Gene: Mcm2 / 17216
• MGIID: 105380
• Length: 904
• Species: Mus musculus
• Alignment Length: 704
• Identity: 217/704 - (30%)
• Similarity: 343/704 - (48%)
• Gaps: 153/704 - (21%)

  Fly    14 KTFLSEFCKCDDDGKKEFVYGSQLVKLAHREQVLITIDLDDLAEFNESLAEAVVDNCRRYTSIFS 78
            |..:|:.||   :.::..|...:  .||.||.|        ||.|   |.||..:..:.:.....
Mouse   216 KERISDMCK---ENRESLVVNYE--DLAAREHV--------LAYF---LPEAPAELLQIFDEAAL 264

  Fly    79 DVIAELLPSYKQQEVHAKDALDVYIEHRLMMESRTRNPMEQRDERNSFPSELMKRFEVGFKPLST 143
            :|:..:.|.|.:...|    :.|.|.|..::|
Mouse   265 EVVLAMYPKYDRITNH----IHVRISHLPLVE--------------------------------- 292

  Fly   144 EKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRCG----------SETYQPVNSL 198
                .:|.::..|:.:|:...|:||.||.|.|.:.:..|.|.:|.          ::..:|
Mouse   293 ----ELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCSKCNFVLGPFCQSQNQEVKP---- 349

  Fly   199 SFTPVHDCPSDDCRVNKAGGRLYLQTRGSKFVKFQEVKMQEHSDQVPVGHIPRSMTIMCRGEVTR 263
                 ..||  :|   ::.|...:....:.:..:|.:::||...:|..|.:|||...:...::..
Mouse   350 -----GSCP--EC---QSAGPFEINMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLADLVD 404

  Fly   264 MAQPGDHIVVSGVF-------------LPLMRTGFAQMIQGLLSETFLQAHRIICINKND----- 310
            ..:|||.|.::|::             .|:    ||.:|        |..|    :.|.|
Mouse   405 SCKPGDEIELTGIYHNNYDGSLNTANGFPV----FATII--------LANH----VAKKDNKVAV 453

  Fly   311 -EISDKDAELTPEELEELAQD-DFYERLATSLAPEIYGHLDVKKALLLLLVGGVDKRPDGM-KIR 372
             |::|:|.::    :..|::| ...|::..|:||.||||.|:|:.|.|.|.||..|.|.|. |:|
Mouse   454 GELTDEDVKM----ITGLSKDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVR 514

  Fly   373 GNINICLMGDPGVAKSQLLGYISRLAVRSQYTTGRGSSGVGLTAAVMKDPLTGEMTLEGGALVLA 437
            |:||:.|.||||.||||.|.||.:::.|:.:|||:|:|.|||||.|.:.|::.|.|||.||||||
Mouse   515 GDINVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLA 579

  Fly   438 DQGVCCIDEFDKMADQDRTAIHEVMEQQTISIAKAGIMTTLNARVSILAAANPAFGRYNPRRTVE 502
            |:|||.|||||||.|||||:|||.||||:|||:||||:|:|.||.:::|||||..|||:|..|..
Mouse   580 DRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFS 644

  Fly   503 QNIQLPAALLSRFDLLWLIQDKPDRDNDLRLAKHITYVHSHSKQPPTR----------------- 550
            :|:.|...::||||:|.:::|..|...|..||:.:  |.||.:..|:.
Mouse   645 ENVDLTEPIISRFDVLCVVRDTVDPVQDEMLARFV--VGSHVRHHPSNKKDEGLTNGGTLEPAMP 707

  Fly   551 ----VKALDMNLMRRYINLCK-RKNPTIPDELTDYIVGAYVELRREARNQKDMTFTSARNLLGIL 610
                |:.|...::::||...| |..|.:.....|.:...|.:||:|:.....:..| .|::..::
Mouse   708 NTYGVEPLPQEVLKKYIIYAKERVRPKLNQMDQDKVARMYSDLRKESMATGSIPIT-VRHIESMI 771

  Fly   611 RLSTALARLRLSDSVEKDDVAEALRLLEMSKDSLNQIHEHQKGHVPNTSDRIFA 664
            |::.|.||:.|.|.|.:|||..|:|::      :....:.||..|..:..:.||
Mouse   772 RMAEAHARMHLRDYVMEDDVNMAIRVM------MESFIDTQKFSVMRSMRKTFA 819

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm7	NP_523984.1	MCM_N	10..103	CDD:464206	21/88 (24%)
		MCM	145..641	CDD:475121	188/548 (34%)
Mcm2	NP_032590.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..166
		Interaction with KAT7. /evidence=ECO:0000269|PubMed:11278932	2..257		16/56 (29%)
		Interaction with DNJC9. /evidence=ECO:0000250|UniProtKB:P49736	61..130
		MCM2_N	72..182	CDD:403724
		MCM_N	197..287	CDD:464206	22/90 (24%)
		MCM	291..803	CDD:214631	189/591 (32%)
		Arginine finger	655..658		2/2 (100%)