DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm7 and Mcm2

DIOPT Version :9

Sequence 1:	NP_523984.1	Gene:	Mcm7 / 39014	FlyBaseID:	FBgn0020633	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_032590.2	Gene:	Mcm2 / 17216	MGIID:	105380	Length:	904	Species:	Mus musculus

Alignment Length:	704	Identity:	217/704 - (30%)
Similarity:	343/704 - (48%)	Gaps:	153/704 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KTFLSEFCKCDDDGKKEFVYGSQLVKLAHREQVLITIDLDDLAEFNESLAEAVVDNCRRYTSIFS 78
            |..:|:.||   :.::..|...:  .||.||.|        ||.|   |.||..:..:.:.....
Mouse   216 KERISDMCK---ENRESLVVNYE--DLAAREHV--------LAYF---LPEAPAELLQIFDEAAL 264

  Fly    79 DVIAELLPSYKQQEVHAKDALDVYIEHRLMMESRTRNPMEQRDERNSFPSELMKRFEVGFKPLST 143
            :|:..:.|.|.:...|    :.|.|.|..::|
Mouse   265 EVVLAMYPKYDRITNH----IHVRISHLPLVE--------------------------------- 292

  Fly   144 EKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRCG----------SETYQPVNSL 198
                .:|.::..|:.:|:...|:||.||.|.|.:.:..|.|.:|.          ::..:|
Mouse   293 ----ELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCSKCNFVLGPFCQSQNQEVKP---- 349

  Fly   199 SFTPVHDCPSDDCRVNKAGGRLYLQTRGSKFVKFQEVKMQEHSDQVPVGHIPRSMTIMCRGEVTR 263
                 ..||  :|   ::.|...:....:.:..:|.:::||...:|..|.:|||...:...::..
Mouse   350 -----GSCP--EC---QSAGPFEINMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLADLVD 404

  Fly   264 MAQPGDHIVVSGVF-------------LPLMRTGFAQMIQGLLSETFLQAHRIICINKND----- 310
            ..:|||.|.::|::             .|:    ||.:|        |..|    :.|.|
Mouse   405 SCKPGDEIELTGIYHNNYDGSLNTANGFPV----FATII--------LANH----VAKKDNKVAV 453

  Fly   311 -EISDKDAELTPEELEELAQD-DFYERLATSLAPEIYGHLDVKKALLLLLVGGVDKRPDGM-KIR 372
             |::|:|.::    :..|::| ...|::..|:||.||||.|:|:.|.|.|.||..|.|.|. |:|
Mouse   454 GELTDEDVKM----ITGLSKDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVR 514

  Fly   373 GNINICLMGDPGVAKSQLLGYISRLAVRSQYTTGRGSSGVGLTAAVMKDPLTGEMTLEGGALVLA 437
            |:||:.|.||||.||||.|.||.:::.|:.:|||:|:|.|||||.|.:.|::.|.|||.||||||
Mouse   515 GDINVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLA 579

  Fly   438 DQGVCCIDEFDKMADQDRTAIHEVMEQQTISIAKAGIMTTLNARVSILAAANPAFGRYNPRRTVE 502
            |:|||.|||||||.|||||:|||.||||:|||:||||:|:|.||.:::|||||..|||:|..|..
Mouse   580 DRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFS 644

  Fly   503 QNIQLPAALLSRFDLLWLIQDKPDRDNDLRLAKHITYVHSHSKQPPTR----------------- 550
            :|:.|...::||||:|.:::|..|...|..||:.:  |.||.:..|:.
Mouse   645 ENVDLTEPIISRFDVLCVVRDTVDPVQDEMLARFV--VGSHVRHHPSNKKDEGLTNGGTLEPAMP 707

  Fly   551 ----VKALDMNLMRRYINLCK-RKNPTIPDELTDYIVGAYVELRREARNQKDMTFTSARNLLGIL 610
                |:.|...::::||...| |..|.:.....|.:...|.:||:|:.....:..| .|::..::
Mouse   708 NTYGVEPLPQEVLKKYIIYAKERVRPKLNQMDQDKVARMYSDLRKESMATGSIPIT-VRHIESMI 771

  Fly   611 RLSTALARLRLSDSVEKDDVAEALRLLEMSKDSLNQIHEHQKGHVPNTSDRIFA 664
            |::.|.||:.|.|.|.:|||..|:|::      :....:.||..|..:..:.||
Mouse   772 RMAEAHARMHLRDYVMEDDVNMAIRVM------MESFIDTQKFSVMRSMRKTFA 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm7	NP_523984.1	MCM_N	13..97	CDD:379644	20/82 (24%)
Mcm7	NP_523984.1	MCM	145..641	CDD:214631	188/548 (34%)
Mcm2	NP_032590.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..166
		Interaction with KAT7. /evidence=ECO:0000269\|PubMed:11278932	2..257		16/56 (29%)
		MCM2_N	72..182	CDD:289392
		MCM_N	198..310	CDD:291233	27/150 (18%)
		MCM	291..803	CDD:214631	189/591 (32%)
		P-loop_NTPase	485..>632	CDD:304359	91/146 (62%)
		Arginine finger	655..658		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820