DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm7 and Mcm3

DIOPT Version :9

Sequence 1:	NP_523984.1	Gene:	Mcm7 / 39014	FlyBaseID:	FBgn0020633	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_032589.1	Gene:	Mcm3 / 17215	MGIID:	101845	Length:	812	Species:	Mus musculus

Alignment Length:	706	Identity:	232/706 - (32%)
Similarity:	347/706 - (49%)	Gaps:	139/706 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ARRDYAQDRESIKTFLSEFCKCDDDGKKEFVYGSQLVKLAHREQVLITIDLDDLAEFNESLAEAV 66
            |:|||..       ||       ||.:.:.:|.:::.:|....|..:.:.::||...||..|..:
Mouse    15 AQRDYLD-------FL-------DDEEDQGIYQNKVRELISDNQYRLIVSVNDLRRKNEKRANRL 65

  Fly    67 VDNCRR----YTSIFSDVIAELLPSYKQQEVHAKDALDVYIEHRLMMESRTRNPMEQRDERNSFP 127
            ::|...    :.....|.:|.:..:|.:|
Mouse    66 LNNAFEELVAFQRALKDFVASIDATYAKQ------------------------------------ 94

  Fly   128 SELMKRFEVGFKPLSTEKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTC---DRCGS 189
               .:.|.:|.:.....|..|.|.:.:..:..:|.|.||||:|:.|:|.:|.:.:.|   .:...
Mouse    95 ---YEEFYIGLEGSFGSKHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIE 156

  Fly   190 ETYQPVNSL-SFTPVHDCPSDDCRVNKAGGRLYLQTRG--SKFVKFQEVKMQEHSDQVPVGHIPR 251
            ..|..:.:| :|......|:.|...|.      |:|..  |.:...|.:.:||..::.|.|.:||
Mouse   157 RRYSDLTTLVAFPSSSVYPTKDEENNP------LETEYGLSVYKDHQTITIQEMPEKAPAGQLPR 215

  Fly   252 SMTIMCRGEVTRMAQPGDHIVVSGVF--LPLMRTGFAQMIQGLLSETFLQAHRIICINKNDEISD 314
            |:.::...::....:|||.|.|.|.:  ||..:..:.       |.||    |.:.|..|.:...
Mouse   216 SVDVILDDDLVDKVKPGDRIQVVGTYRCLPGKKGCYT-------SGTF----RTVLIACNVKQMS 269

  Fly   315 KDAE--LTPEELEELAQ------DDFYERLATSLAPEIYGHLDVKKALLLLLVGGVDKR-PDGMK 370
            ||.:  .:.:::.::.:      .|.:|:||.||||.|:||..||||:|.||:|||::. .:|..
Mouse   270 KDIQPAFSADDIAKIKKFSKTRSKDVFEQLARSLAPSIHGHDYVKKAILCLLLGGVERELENGSH 334

  Fly   371 IRGNINICLMGDPGVAKSQLLGYISRLAVRSQYTTGRGSSGVGLTAAVMKDPLTGEMTLEGGALV 435
            |||:|||.|:|||.|||||||.|:...|.|:..|||||||||||||||..|..|||..||.||:|
Mouse   335 IRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMV 399

  Fly   436 LADQGVCCIDEFDKMADQDRTAIHEVMEQQTISIAKAGIMTTLNARVSILAAANPAFGRYNPRRT 500
            |||:||.||||||||:|.|||||||||||..::||||||...||||.|:||||||.:|||:..:|
Mouse   400 LADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKT 464

  Fly   501 VEQNIQLPAALLSRFDLLWLIQDKPDRDNDLRLAKHITYVHSH---------------------- 543
            ..:||.|..:||||||||:::.|:.|.:.|..::.|:..:|.:
Mouse   465 PMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHQYRAPGEQDGDALPLGSSVDILAT 529

  Fly   544 -------SKQPPTRV----------------KALDMNLMRRYINLCKRKNPTIPDELTDYIVGAY 585
                   ..|..||:                |.:....|::||::.|...||:..|...||...|
Mouse   530 DDPDFTQDDQQDTRIYEKHDSLLHGTKKKKEKMVSAAFMKKYIHVAKIIKPTLTQESAAYIAEEY 594

  Fly   586 VELRREARNQKDMTFTS---ARNLLGILRLSTALARLRLSDSVEKDDVAEALRLLE 638
            ..||.:.....|...||   ||.|..::||:||.|:.|:|.:|:..|..||:.|::
Mouse   595 SRLRSQDSMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQ 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm7	NP_523984.1	MCM_N	13..97	CDD:379644	17/87 (20%)
Mcm7	NP_523984.1	MCM	145..641	CDD:214631	209/559 (37%)
Mcm3	NP_032589.1	MCM_N	17..129	CDD:291233	27/164 (16%)
		MCM	109..654	CDD:214631	209/559 (37%)
		P-loop_NTPase	340..479	CDD:304359	92/138 (67%)
		Arginine finger	477..480		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	664..744
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810