Protein Alignment Mcm7 and MCMDC2

DIOPT Version :9

• Sequence 1: NP_523984.1
• Gene: Mcm7 / 39014
• FlyBaseID: FBgn0020633
• Length: 720
• Species: Drosophila melanogaster
• Sequence 2: NP_775789.3
• Gene: MCMDC2 / 157777
• HGNCID: 26368
• Length: 681
• Species: Homo sapiens
• Alignment Length: 771
• Identity: 132/771 - (17%)
• Similarity: 227/771 - (29%)
• Gaps: 298/771 - (38%)

  Fly     6 YAQDRESIKTFLSEFCKCDDDGKKEFVYGSQLVKLAHREQVLITIDLDDLAEFNESLAEAVVDNC 70
            |......::.|:.: ||..:|.|:.:.        .:|.::|  |:..|:.|.:..|...::...
Human    13 YLDRSGGLQKFIDD-CKYYNDSKQSYA--------VYRFKIL--INPSDVVELDAELGNHILHQP 66

  Fly    71 RRYTSIFSDV----------IAEL-----------------LPSYKQQEVHAKDALDV------Y 102
            .:...:|..|          |.:|                 ||||         .||:      |
Human    67 LKAAEVFQSVCFIAVKTLSLIGQLQTETQINIVLKLTHLPPLPSY---------GLDLCEFPLDY 122

  Fly   103 IEHR--------LMMESRTRNPMEQRDERNSFPSELMKRFEVGFK------PLSTEKAHSIREVK 153
            ...|        :.|.:.|:.....|...:.....|.|    ||:      |.:||.|
Human   123 TSQRFYMMQGIVIAMTTITKYTQGARFLCSDEACPLSK----GFQYIRVHVPGATESA------- 176

  Fly   154 AQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRCGSETYQPVNSLSFTPVHDCPSDDCRVNKAGG 218
                    |:|.               .:.|:.|.|..                .:|.:....|.
Human   177 --------TIRN---------------DFLCNLCASSL----------------QEDRKFRVLGD 202

  Fly   219 RLYLQTRGSKFVKFQEVKMQEHSDQVPVGHIPRSMTIMCRGEVTRMAQPGDHIVVSGVFLPL--- 280
            :..::...:|.::    ..|.:|:..|...  :|:||..|.|.......|:...:.|:  |.
Human   203 KQIVEIIATKALR----AFQGYSNNQPFRF--QSLTIFLRDESVNKMNIGNEYKIIGI--PTCVK 259

  Fly   281 -------------------MRTGFAQMIQGLLSETFLQAHRIICINKNDEISDKDAELTPEELEE 326
                               :.:|.:...:.|||.|.....:...|..|...|    ::||
Human   260 TSQTAVCIEANSITFCNSKVPSGISDNFRCLLSLTSSSCWKFTAILANIFAS----QITP----- 315

  Fly   327 LAQDDFYERLATSLAPEIYGHLDVKKALLLLLVGGVDKRPDGMKIRGNINICLMGDPGVAKSQLL 391
                           |..|..|  |..||:.||...|:..:   :...::|.::....:...:||
Human   316 ---------------PGTYNLL--KLCLLMSLVQTTDRNKE---LEDCLDILIITSDTLLIDRLL 360

  Fly   392 GYISRLAVRSQY---------TTGRGSSGVGLTAAVMKDPLTGEMTLEGGALVLADQGVCCIDEF 447
            .:...|..|...         |..|...|            ||.::::.|:.:||..|:|.|.:.
Human   361 NFSINLVPRGIRHLVSTEIFPTLSRNKYG------------TGAVSIQAGSALLAKGGICFIGDL 413

  Fly   448 DKMADQDRTAIHEVMEQQTISIAKAGIMTTLNARVSILAAANPAFGRYNPRRTVEQNIQLPAALL 512
            ..........:..|:|.::|::...|                ..||     ..::|.:..|...
Human   414 ASHKKDKLEQLQTVLESRSITVYIPG----------------KKFG-----EDIDQQMTFPVQC- 456

  Fly   513 SRFDLLWLIQDKPDRDNDLRLAKHITYVHSHSKQPPTRVKAL---------DMNLMRRY---INL 565
                ..|...|                |.|.|::...::..|         ..||:..:   ||
Human   457 ----SFWSFVD----------------VDSSSRRNAQKINTLIGQMDCSLIPANLVEAFGLLIN- 500

  Fly   566 CKRKNPTIP-------------------------------DELTDYIVGAYVELRREARNQKDMT 599
            |...:|..|                               ::|..:.....||...||.......
Human   501 CNESSPCHPFLPTVQHTLNKAINPEGLFYAASRQFTTEDFEKLLAFAKNLNVEFSLEAERMTHGY 565

  Fly   600 FTSARN---------------LLGILRLSTALARLRLSDSVEKDDVAEALRLLEMS 640
            :.::|.               |..::.||.|.|||.|.:.|.|:||..|..|.|.|
Human   566 YLASRRIRTGSVCGSKLSASALKYLVFLSEAHARLNLRNKVLKEDVLIAALLFETS 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm7	NP_523984.1	MCM_N	13..97	CDD:379644	19/110 (17%)
		MCM	145..641	CDD:214631	98/585 (17%)
MCMDC2	NP_775789.3	PTZ00111	<358..>435	CDD:173403	18/88 (20%)
		MCM	<514..622	CDD:278895	22/108 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900