DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm7 and AgaP_AGAP004275

DIOPT Version :9

Sequence 1:	NP_523984.1	Gene:	Mcm7 / 39014	FlyBaseID:	FBgn0020633	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	XP_313198.5	Gene:	AgaP_AGAP004275 / 1274119	VectorBaseID:	AGAP004275	Length:	900	Species:	Anopheles gambiae

Alignment Length:	726	Identity:	232/726 - (31%)
Similarity:	359/726 - (49%)	Gaps:	106/726 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RESIKTFLSEFCKCDDDGKKEFVYGSQLVKLAHREQVLITIDLDDLAEFNESLA----EAVVDNC 70
            |..|....:.|.:...|.|..:||..::.::..:......:...|||.....||    ||.....
Mosquito   181 RTEISNRFNSFLRTFVDDKGHYVYRERIRRMCEQNNSSFVVSFSDLAHNQHVLAYFLPEAPFQML 245

  Fly    71 RRYTSIFSDVIAELLPSYKQ--QEVHAKDALDVYIEHRLMMESRTRNPMEQRDERNSFPSELMKR 133
            .....:..:::..|.|:|::  .|:|.:
Mosquito   246 DILDKVAKEMVLSLYPTYERVTNEIHVR------------------------------------- 273

  Fly   134 FEVGFKPLSTEKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRCGSETYQPVNSL 198
              :...||..|    :|..:..|:.:||...|:||..|.|.|.:.|..|.|.:||......|.|.
Mosquito   274 --ISDLPLVEE----LRTFRKLHLNQLVRTLGVVTATTGVLPQLSVIKYDCVKCGYVLGPFVQSQ 332

  Fly   199 SFTPVH--DCPSDDCRVNKAGGRLYLQTRGSKFVKFQEVKMQEHSDQVPVGHIPRSMTIMCRGEV 261
            : |.|.  .||  :|   ::.|...:....:.:..:|::.:||...::|.|.||||...:...::
Mosquito   333 N-TEVKPGSCP--EC---QSVGPFSINMEQTLYRNYQKITLQESPGRIPAGRIPRSKDCVLLADL 391

  Fly   262 TRMAQPGDHIVVSGVFLPLMRTGFAQMIQGL-LSETFLQAHRIICINKNDEISDKDAELTPEE-- 323
            ....:|||.|.|:|::.. ...|.....||. :..|.|.|:.::..:....:    |.||.|:
Mosquito   392 CDQCKPGDEIEVTGIYTN-NYDGSLNTEQGFPVFATVLIANHLVVKDSKQVV----ASLTDEDIS 451

  Fly   324 -LEELAQDD-FYERLATSLAPEIYGHLDVKKALLLLLVGGVDKRPDGM-KIRGNINICLMGDPGV 385
             ::.|::|. ..:|:..|:||.||||..:|:.|.|.|.||..|.|... ||||:|||.|.||||.
Mosquito   452 TIQRLSRDPRISDRITQSMAPSIYGHEYIKRGLALCLFGGESKNPGNKHKIRGDINILLCGDPGT 516

  Fly   386 AKSQLLGYISRLAVRSQYTTGRGSSGVGLTAAVMKDPLTGEMTLEGGALVLADQGVCCIDEFDKM 450
            ||||.|.|..::|.|:.:|||:|:|.|||||.|.::|.|.|.|||.|||||||.|||.|||||||
Mosquito   517 AKSQFLKYTEKIAPRAVFTTGQGASAVGLTAYVRRNPTTREWTLEAGALVLADMGVCLIDEFDKM 581

  Fly   451 ADQDRTAIHEVMEQQTISIAKAGIMTTLNARVSILAAANPAFGRYNPRRTVEQNIQLPAALLSRF 515
            .|||||:|||.||||:||::||||:|:|.||.:::|||||..|||:|..|..:|:.|...:||||
Mosquito   582 NDQDRTSIHEAMEQQSISVSKAGIVTSLQARCAVIAAANPIGGRYDPSMTFSENVNLSEPILSRF 646

  Fly   516 DLLWLIQDKPDRDNDLRLAKHITYVHSHSKQPPTR-----------VKALDMNLMRRYINLCKRK 569
            |:|.:::|:.|...|..||:.:  |.||.|..|::           ...:..:|:::||...|..
Mosquito   647 DILCVVKDEFDPMQDKHLAEFV--VASHIKHHPSKEAEEPDTQPEDTMQIPQDLLKKYIVYAKEN 709

  Fly   570 -NPTIPDELTDYIVGAYVELRREARNQKDMTFTSARNLLGILRLSTALARLRLSDSVEKDDVAEA 633
             :|.:.:...|.|...|.:||:|:.:...:..| .|::..::|:|.|.||:.|.|:|:..||..|
Mosquito   710 VHPKLSNMDQDKIANMYSQLRQESLSTGSLPIT-VRHIESVIRMSEAHARMHLRDTVQDVDVNMA 773

  Fly   634 LRL-----LEMSKDSL--------NQIHEHQKGHVPNTSDRIFAIVRELAGSGKAVKISDIMDRC 685
            :|:     :|..|.|:        .:....|:.|    |:.:|.|:|:|.....|.:      ||
Mosquito   774 IRMMLESFIEAQKFSVMKKMRATFQKYLSFQRDH----SELLFFILRQLTLDQLAYQ------RC 828

  Fly   686 TTKGFKPDQVD 696
            ...|.:..|.:
Mosquito   829 KEAGRRGKQAE 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm7	NP_523984.1	MCM_N	13..97	CDD:379644	18/89 (20%)
Mcm7	NP_523984.1	MCM	145..641	CDD:214631	196/520 (38%)
AgaP_AGAP004275	XP_313198.5	MCM2_N	37..171	CDD:289392
		MCM_N	187..296	CDD:291233	23/151 (15%)
		MCM	280..782	CDD:214631	196/519 (38%)
		P-loop_NTPase	474..648	CDD:304359	104/173 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D15169at50557
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820