DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm7 and mcm8

DIOPT Version :9

Sequence 1:	NP_523984.1	Gene:	Mcm7 / 39014	FlyBaseID:	FBgn0020633	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	XP_002665161.2	Gene:	mcm8 / 100333576	ZFINID:	ZDB-GENE-120927-1	Length:	852	Species:	Danio rerio

Alignment Length:	725	Identity:	221/725 - (30%)
Similarity:	343/725 - (47%)	Gaps:	123/725 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 FVYGSQLV-KLAHREQVLIT-IDLDDLAEFNESLAEAVVDNCRRYTSIFSD-----VIAELLPSY 88
            ||..|..| |:...||...: |||.|..|. |.....:||    |..:.|:     .:.:|....
Zfish    98 FVESSPYVEKIKVFEQYFTSQIDLYDKDEI-ERKGSILVD----YKDLLSNKQVSHSLPDLARDL 157

  Fly    89 KQQEVHAKDALDVYIEHRLMMESRTRNPMEQRDERNSFPSELMKRFEVGFKPL-----------S 142
            |:......|.|.|.|...|.::.          ||::...:..:....|.:|:           :
Zfish   158 KEMPEKILDCLGVAIHQVLTLDL----------ERHAAELQGQEELPAGIRPIINIPHISARLYN 212

  Fly   143 TEKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRCGSETYQPVNSLSFTPVHDCP 207
            .|....::.::|...||.|.:||.|.|.:.:||:.:...:.|:.||......:....:|....|.
Zfish   213 YEPLTPLKSLRANLYGKFVVIRGTVVRVSNIKPLCMKLAFVCNSCGDTQSVTLPDGKYTMPTKCL 277

  Fly   208 SDDCRVNKAGGRLYLQTRGSKF---VKFQEVKMQE--HSDQVPVGHIPRSMTIMCRGEVTR---- 263
            ..:||     ||.:...|.|.|   |.:|.:|:||  ..||...|.|||  ||.|  |:|:
Zfish   278 QSECR-----GRSFTPNRSSPFTLTVDWQTIKVQELMSGDQRESGRIPR--TIEC--ELTQDLVD 333

  Fly   264 MAQPGDHIVVSGVFLPLMRTGFAQ----MIQGLLSETFLQAHRIICI--NKNDEISDKD-----A 317
            ...|||.:.::||.......|..:    ....||   ::||:.:...  .|:..:|:.:     .
Zfish   334 SCVPGDMVTITGVIKVSNEEGSTRNKKDKCMFLL---YIQANSVSNSKGQKSKAVSESEGQGPSV 395

  Fly   318 ELTPEEL----EELAQDDFYERLATSLAPEIYGHLDVKKALLLLLVGGVDKRPDG---MKIRGNI 375
            |.:.::|    |..||:|.::.:..||.|.|||||.||..|.|.|.||..|..|.   :.|||:.
Zfish   396 EFSIKDLYAIQEIQAQEDLFKLIVNSLCPVIYGHLLVKAGLALALFGGCQKYVDDKNRIPIRGDP 460

  Fly   376 NICLMGDPGVAKSQLLGYISRLAVRSQYTTGRGSSGVGLTAAVMKDPLTGEMTLEGGALVLADQG 440
            ::.::||||:.|||:|..:..:|.|..|..|..::..|||.::.:|..:|:..||.|||||.|||
Zfish   461 HMLIVGDPGLGKSQMLQAVCNVAPRGVYVCGNTTTTSGLTVSLSRDSGSGDYALEAGALVLGDQG 525

  Fly   441 VCCIDEFDKMADQDRTAIHEVMEQQTISIAKAGIMTTLNARVSILAAANPAFGRYNPRRTVEQNI 505
            :|||||||||..|.: |:.|.||||:||:|||||:.||.||.||:|||||..|.||..:||.:|:
Zfish   526 ICCIDEFDKMGSQHQ-ALLEAMEQQSISLAKAGIVCTLPARTSIIAAANPVGGHYNKGKTVSENL 589

  Fly   506 QLPAALLSRFDLLWLIQDKPDRDNDLRLAKHI----------------TYVHSHSKQ-------- 546
            ::.:||||||||::::.|.|:.|:|..|::|:                |..::|...
Zfish   590 KMGSALLSRFDLVFILLDTPNEDHDHLLSEHVMAMRAGKSGAVSGAAATRFNTHESSISILEVSS 654

  Fly   547 -----------PPTRVKALDMNLMRRYINLCKR-KNPTIPDELTDYIVGAYVELRREARNQ-KDM 598
                       |......:...|:|:|:...:. .:||:..|....:...|:|||::  || .|.
Zfish   655 EKPLADTLKLVPGEAFDPIPHQLLRKYVGYARHYVHPTLSAEAAQVLQDFYLELRKQ--NQTADS 717

  Fly   599 TFTSARNLLGILRLSTALARLRLSDSVEKDDVAEALRLLEMSKDSLNQIHEHQKGHVPNTSDRIF 663
            |..:.|.|..::||:.|.||:.|.:...:.|..:   ::|:.|.||...:..:.|.:.
Zfish   718 TPITTRQLESLIRLTEARARVELREKATQSDAED---VVEIMKHSLTDTYSDEFGRLD------- 772

  Fly   664 AIVRELAGSG 673
             ..|...|||
Zfish   773 -FDRSQLGSG 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm7	NP_523984.1	MCM_N	13..97	CDD:379644	19/72 (26%)
Mcm7	NP_523984.1	MCM	145..641	CDD:214631	184/559 (33%)
mcm8	XP_002665161.2	Mcm2	110..801	CDD:224162	216/713 (30%)
		MCM_N	111..235	CDD:291233	28/138 (20%)
		AAA	451..605	CDD:99707	78/154 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910