DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm7 and mcm3l

DIOPT Version :9

Sequence 1:	NP_523984.1	Gene:	Mcm7 / 39014	FlyBaseID:	FBgn0020633	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_001164539.1	Gene:	mcm3l / 100147915	ZFINID:	ZDB-GENE-040121-2	Length:	807	Species:	Danio rerio

Alignment Length:	771	Identity:	246/771 - (31%)
Similarity:	377/771 - (48%)	Gaps:	160/771 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RESIKTFLSEFCKCDDDGKKEFVYGSQLVKLAHREQVLITIDLDDLAEFNESLAEAVVDNC---- 70
            |||.:.:| :|.   ||.:.:.:|..::..:....|..:.::::||...:|..|:.::.|.
Zfish    11 RESQREYL-DFL---DDDQDQGIYHEKVRSMVSDGQCRLIVNINDLRRKSEKRAKELLKNAFAEL 71

  Fly    71 RRYTSIFSDVIAELLPSYKQQEVHAKDALDVYIEHRLMMESRTRNPMEQRDERNSFPSELMKRFE 135
            ..:.....|::|.:..:|.:|                                       .:.|.
Zfish    72 VAFQKALKDLVASIDATYAKQ---------------------------------------FEEFH 97

  Fly   136 VGFKPLSTEKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTC---DRCGSETYQPVNS 197
            |||:.....|..|.|.:.|:.:|.||.|.||||:|:.|:|.::.:.:.|   .:.....|..:.|
Zfish    98 VGFEGSFGNKHVSPRTLSARFLGNLVCVEGIVTKCSLVRPKIMRSVHYCPATKKTLERKYTDLTS 162

  Fly   198 LSFTPVHDC-PSDDCRVNKAGGRLYLQTRGSK--FVKFQEVKMQEHSDQVPVGHIPRSMTIMCRG 259
            |...|.... |:.|...|.      |:|....  :...|.:.:||..::.|.|.:|||:.|:...
Zfish   163 LDAFPSSAIYPTKDEENNP------LETEFGLCCYKDHQTLTIQEMPEKAPAGQLPRSVDIIAND 221

  Fly   260 EVTRMAQPGDHIVVSGVF--LPLMRTGFAQMIQGLLSETFLQAHRIICINKNDEISDKDAELTP- 321
            ::....:|||.:.:.||:  ||..:.||.       |.||    |.|.:..|.::..|  |:.|
Zfish   222 DLVDRVKPGDRVQIVGVYRCLPAKQGGFT-------SGTF----RTILLANNVKLMSK--EIVPT 273

  Fly   322 ---EELEELAQ------DDFYERLATSLAPEIYGHLDVKKALLLLLVGGVDKR-PDGMKIRGNIN 376
               :::.::.:      .|.:|:|:.||||.|:||..:|||:|.||:||.:.. .:|.:|||:||
Zfish   274 FSGDDVAKIKKFCKAHSKDVFEQLSRSLAPSIHGHEYIKKAILCLLLGGNETNLENGTRIRGDIN 338

  Fly   377 ICLMGDPGVAKSQLLGYISRLAVRSQYTTGRGSSGVGLTAAVMKDPLTGEMTLEGGALVLADQGV 441
            |.|:|||.|||||||.|:...|.|:..|||||||||||||||..|..|||..||.||:||||:||
Zfish   339 ILLIGDPSVAKSQLLRYVLFTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGV 403

  Fly   442 CCIDEFDKMADQDRTAIHEVMEQQTISIAKAGIMTTLNARVSILAAANPAFGRYNPRRTVEQNIQ 506
            .||||||||:|.|||||||||||..::|:||||...||||.|:||||||.:|||:..:|..:||.
Zfish   404 VCIDEFDKMSDMDRTAIHEVMEQGRVTISKAGIQARLNARCSVLAAANPVYGRYDQYKTPMENIG 468

  Fly   507 LPAALLSRFDLLWLIQDKPDRDNDLRLAKHI---------------------------------- 537
            |..:||||||||:::.|:.|.|:|..:::|:
Zfish   469 LQDSLLSRFDLLFIVLDQMDPDSDKEISEHVLRMHRYRAPGEAEGTAMPLGSTVDVFATEDPNIT 533

  Fly   538 --------------TYVHSHSKQPPTRVKALDMNLMRRYINLCKRKNPTIPDELTDYIVGAYVEL 588
                          ..:|.|.|:   |.|.:.|..:|:||::.|...|.:..|.:|||...|..|
Zfish   534 EASEQELQIYEKKDNVLHGHRKK---REKIVTMEFIRKYIHVAKLVKPVLTQEASDYIAEEYSRL 595

  Fly   589 RREARNQKDMTFT---SARNLLGILRLSTALARLRLSDSVEKDDVAEALRLLEMS--KDSLNQIH 648
            |...:...|...|   :||.|..::|||||.|:.|:|.:|:..|...||.|::.:  |..|.::
Zfish   596 RSHDQVNSDSARTMPVTARALETMIRLSTAHAKARMSKTVDLADAEAALELMQFAYFKKILEKV- 659

  Fly   649 EHQKGHVPNTSDRIFAIVRELAGSGKAVKISDIMDRCTTKGF-KPDQVDKCIDDYE 703
              :|..||..|:               :.:|...:..:.:.. |..::.|..||.|
Zfish   660 --KKRKVPEDSE---------------IDVSQSQETDSQRSLRKRSRISKDGDDVE 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm7	NP_523984.1	MCM_N	13..97	CDD:379644	15/87 (17%)
Mcm7	NP_523984.1	MCM	145..641	CDD:214631	212/567 (37%)
mcm3l	NP_001164539.1	MCM_N	29..127	CDD:291233	23/136 (17%)
		MCM	107..652	CDD:214631	212/566 (37%)
		P-loop_NTPase	338..477	CDD:304359	91/138 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820