DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dally and gpc2

DIOPT Version :9

Sequence 1:	NP_001246685.1	Gene:	dally / 39013	FlyBaseID:	FBgn0263930	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_001289182.1	Gene:	gpc2 / 503792	ZFINID:	ZDB-GENE-050302-31	Length:	576	Species:	Danio rerio

Alignment Length:	559	Identity:	127/559 - (22%)
Similarity:	222/559 - (39%)	Gaps:	102/559 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 CDAVKSYFES--IDIKSSGTYSEKGAICGG----------NCCNNATELEL------------RD 109
            |.|.:|..||  :..::.|:......:..|          .||::..|..|            ||
Zfish    22 CGAARSCAESRRVYAENHGSIPAPQTLISGEHLRFCPRDYTCCSSHMEDTLTQHSQQHFLSAVRD 86

  Fly   110 KAAGMFEQLLHHHTSSLRGVLETNAKQFQSHVLELAQISENMTHSLFSKVYTRMVPSSRMMIHQL 174
            .:..:|....|.|            ::|.....:|..:||.....:|:..|.|....:..:|.||
Zfish    87 SSHFLFSSFSHTH------------RRFDELFRKLIDVSEESMSEMFTHTYGRRYTQNAHIITQL 139

  Fly   175 YTEIMNHLIYTSNYTNSNGQLGRRGIGSVQSNLEEAVRHFFVQLFPVAYHQMVHLSKNNLGDLHE 239
            :|::..:      ||.     ||       .:|.|.:..|:..|....:..:     |...:|.:
Zfish   140 FTDLRRY------YTG-----GR-------VSLAEVLDDFWAGLLECVFSLL-----NPQYELSD 181

  Fly   240 DYVNCLQHNFDEMHPFGDIPQQVQSNLGKSVHMSNVFMNALLQAAEVLSEADALYGEQLTDTCKL 304
            ||:.|::.:.:::.||||.|.::.:.:.::...:...:.||....|::|:|..|   :....|..
Zfish   182 DYLECVRKHSEQLLPFGDRPLKLHTQVSRAFTAARALVQALAAGREIVSKATQL---RAGPECVR 243

  Fly   305 HLLKMHYCPNCNGHHSSSRSETKLCYGYCKNVMRGCSAEYAGLLDSPWSGVVDSLNNLV------ 363
            .|::..:||.|.|..|     .|.|:..|.|:|:||.|..|. |:|.|:..:|:|..:|
Zfish   244 ALMRQWFCPLCRGLPS-----LKPCHSLCLNIMKGCLANQAD-LNSEWNSFIDALTVVVEKLGGP 302

  Fly   364 -TTHILSDTGIINVIKHLQTYFSEAIMAAMHNGPELEKKVKKTCGTPSLTP----YSSGEPDARP 423
             ...:.:|...:.|        ||.||....|...:..||.:.||.|...|    .|:.|.||:|
Zfish   303 FNFELAADAIAVTV--------SEGIMNMQENSISISAKVFQGCGIPRPVPGRNKRSAAERDAKP 359

  Fly   424 ------PPHKNNVKWATDPDPGMVLFLSTIDKSKEFYTTIVDNFCDEQQHSRD---DHSCWSGDR 479
                  ...|.:....||.|..:....:.:...:.|:..:....|.::..:.|   :..||:|..
Zfish   360 KFRSFRTEEKPSSGSGTDLDQLVQELQARLKPMRGFWLALPHTICSDEHTAADVTNEEQCWNGQT 424

  Fly   480 FGDYTQLLINPGTDSQRYNPEVPFNAKAQTGKLNELVDKLFKIRKSIGAAAPSNSIQATH--DIQ 542
            .|.|...:...|..:|..|||:..:......:..:|   :.::|.:|.....:...:.||  |.:
Zfish   425 RGRYLPAVTADGLLNQLNNPELELDVSRPDTRTRQL---MMELRAAIHTLRLAQHGRDTHFTDGE 486

  Fly   543 NDMGEGSGGGEGQ-IGDDEEEYGGAHGSGDGSGDGPHTP 580
            .:.|.|||||..: ..||..||.....:.:...|.|..|
Zfish   487 LEPGSGSGGGASERFSDDWPEYTSFSSTRNTPVDKPLRP 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dally	NP_001246685.1	Glypican	51..622	CDD:279494	127/559 (23%)
gpc2	NP_001289182.1	Glypican	23..576	CDD:279494	126/558 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910