Protein Alignment dally and GPC2

DIOPT Version :10

• Sequence 1: NP_523983.1
• Gene: dally / 39013
• FlyBaseID: FBgn0263930
• Length: 626
• Species: Drosophila melanogaster
• Sequence 2: NP_689955.1
• Gene: GPC2 / 221914
• HGNCID: 4450
• Length: 579
• Species: Homo sapiens
• Alignment Length: 578
• Identity: 127/578 - (21%)
• Similarity: 215/578 - (37%)
• Gaps: 133/578 - (23%)

  Fly    98 CCNNATELELRDKAAGMFEQLLHHHTSSLRGVLETNAKQFQSHVLELAQISENMTHSLFSKVYTR 162
            ||::.||..|..:....|..|:....|.|...|....::|....||:..::::....|||..|.|
Human    68 CCSSETEQRLIRETEATFRGLVEDSGSFLVHTLAARHRKFDEFFLEMLSVAQHSLTQLFSHSYGR 132

  Fly   163 MVPSSRMMIHQLYTEIMNHLIYTSNYTNSNGQLGRRGIGSVQSNLEEAVRHFFVQL----FPVAY 223
            :.....::.:.|::.:.:.             .|..|.|     |::.:..|:.||    ||:.:
Human   133 LYAQHALIFNGLFSRLRDF-------------YGESGEG-----LDDTLADFWAQLLERVFPLLH 179

  Fly   224 HQMVHLSKNNLGDLHEDYVNCLQH----NFDEMHPFGDIPQQVQSNLGKSVHMSNVFMNALLQAA 284
            .|.         ....||:.||..    ....:.||||.|::::..:.:::..:..|:..|....
Human   180 PQY---------SFPPDYLLCLSRLASSTDGSLQPFGDSPRRLRLQITRTLVAARAFVQGLETGR 235

  Fly   285 EVLSEADALYGEQLTDTCKLHLLKMHYCPNCNGHHSSSRSETKLCYGYCKNVMRGCSAEYAGLLD 349
            .|:|||..:   .:::.|...|:::..||.|.|..|     ...|.|:|.||:|||.:...  |:
Human   236 NVVSEALKV---PVSEGCSQALMRLIGCPLCRGVPS-----LMPCQGFCLNVVRGCLSSRG--LE 290

  Fly   350 SPWSGVVDSLNNLVTTHILSDTGIINVIKHLQTYF-------------SEAIMAAMHNGPELEKK 401
            ..|...:|.|      .||:|        .||..|             ||.:|....|..::..:
Human   291 PDWGNYLDGL------LILAD--------KLQGPFSFELTAESIGVKISEGLMYLQENSAKVSAQ 341

  Fly   402 VKKTCGTPSLTPYSSGEPDARPPPHKNNVKWA--TDPD-----PGMVL------FLSTIDKSKEF 453
            |.:.||.|.  |..:....|.||..:....|:  |:.:     .|..|      ....:.:.:.|
Human   342 VFQECGPPD--PVPARNRRAPPPREEAGRLWSMVTEEERPTTAAGTNLHRLVWELRERLARMRGF 404

  Fly   454 YTTIVDNFCDEQQHSRDDH----SCWSGDRFGDYTQLLINPGTDSQRYNPEVPFNAKAQTGKLNE 514
            :..:....|.:.:.:.|..    .||:|...|.|...::......|..|||:..:|.........
Human   405 WARLSLTVCGDSRMAADASLEAAPCWTGAGRGRYLPPVVGGSPAEQVNNPELKVDASGPDVPTRR 469

  Fly   515 LVDKLFKIRKSIGAAAPSNSIQATHDIQ----NDMGEGSGGGEGQIGDDEEEYGGA--------- 566
               :..::|   .|.|...:....||:.    ::...|||||: |..||  ...||
Human   470 ---RRLQLR---AATARMKTAALGHDLDGQDADEDASGSGGGQ-QYADD--WMAGAVAPPARPPR 525

  Fly   567 -------HGSGDGSGDGPHTPIEESEGTTTNEVESRDSGKTSGSNPLEGTATWMLLTL 617
                   .|||...|.|         ....|:..||..|.:.|.:    |.|.::|:|
Human   526 PPYPPRRDGSGGKGGGG---------SARYNQGRSRSGGASIGFH----TQTILILSL 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dally	NP_523983.1	Glypican	51..622	CDD:460084	127/578 (22%)
GPC2	NP_689955.1	Glypican	29..512	CDD:460084	111/505 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	444..468		5/23 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	485..555		20/81 (25%)