DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dally and Gpc1

DIOPT Version :9

Sequence 1:	NP_001246685.1	Gene:	dally / 39013	FlyBaseID:	FBgn0263930	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_057905.1	Gene:	Gpc1 / 14733	MGIID:	1194891	Length:	557	Species:	Mus musculus

Alignment Length:	590	Identity:	140/590 - (23%)
Similarity:	234/590 - (39%)	Gaps:	82/590 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 AKDAVGGSTHQCDAVKSY-----FESIDIKSSGTYSEKGAIC--GGNCCNNATELELRDKAAGMF 115
            |:......:..|..|:..     |...|:..:....|...||  |..||.:..|..|.:.:....
Mouse    21 ARGDPASKSRSCSEVRQIYGAKGFSLSDVPQAEISGEHLRICPQGYTCCTSEMEENLANHSRMEL 85

  Fly   116 EQLLHHHTSSLRGVLETNAKQFQSHVLELAQISENMTHSLFSKVYTRMVPSSRMMIHQLYTEIMN 180
            |..||..:.:|:..|.|.......|...|...||......|...:..:...:......||.|:
Mouse    86 ESALHDSSRALQATLATQLHGIDDHFQRLLNDSERTLQEAFPGAFGDLYTQNTRAFRDLYAEL-- 148

  Fly   181 HLIYTSNYTNSNGQLGRRGIGSVQSNLEEAVRHFFVQLFPVAYHQMVHLSKNNLGDLHEDYVNCL 245
            .|.|             ||   ...:|||.:..|:.:|....:.|: |...     |.:||::||
Mouse   149 RLYY-------------RG---ANLHLEETLAEFWARLLERLFKQL-HPQL-----LPDDYLDCL 191

  Fly   246 QHNFDEMHPFGDIPQQVQSNLGKSVHMSNVFMNALLQAAEVLSEADALYGEQLTDTCKLHLLKMH 310
            ....:.:.||||.|::::....::...:..|:..|..|::|:.:...:   .|...|...::|:.
Mouse   192 GKQAEALRPFGDAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQV---PLAPECSRAIMKLV 253

  Fly   311 YCPNCNGHHSSSRSETKLCYGYCKNVMRGCSAEYAGLLDSPWSGVVDSLNNLVTTHILSDTGIIN 375
            ||.:|.|...:     :.|..||:||::||.|..|. ||:.|..::||: .|:|......:|..:
Mouse   254 YCAHCRGVPGA-----RPCPDYCRNVLKGCLANQAD-LDAEWRNLLDSM-VLITDKFWGPSGAES 311

  Fly   376 VIKHLQTYFSEAIMAAMHNGPELEKKVKKTCGTPSLTPYSSGEPDARPPPHKNNVKWATDPDPGM 440
            ||..:..:.:|||.|...|...|..||.:.||.|.:.|:.||     |...:...|.|....|..
Mouse   312 VIGGVHVWLAEAINALQDNKDTLTAKVIQACGNPKVNPHGSG-----PEEKRRRGKLALQEKPST 371

  Fly   441 VLFLSTIDKSK-------EFYTTIVDNFCDEQ--QHSRDDHSCWSGDRFGDYTQLLINPGTDSQR 496
            ......:.::|       :|:.::....|.|:  .....|..||:|...|.|...::..|..:|.
Mouse   372 GTLEKLVSEAKAQLRDIQDFWISLPGTLCSEKMAMSPASDDRCWNGISKGRYLPEVMGDGLANQI 436

  Fly   497 YNPEVPFNAKAQTGKLNELVDKLFKIRKSIGAAAPSNSIQATHDIQNDMGEGSGGGEGQIGDDEE 561
            .||||..:.......:.:.:.:|..:...:..|...|.:    |.|:...:|||.|.|  |...:
Mouse   437 NNPEVEVDITKPDMTIRQQIMQLKIMTNRLRGAYGGNDV----DFQDASDDGSGSGSG--GGCPD 495

  Fly   562 EYGGAHGSGDGSGDGPHTP-------IEESEGTTTNEVESRDSGKTSGSNPLEGTATWMLLTLVT 619
            :..|...|...|..  .||       :.|.||.           |||.:...| ..::.||.|||
Mouse   496 DTCGRRVSKKSSSS--RTPLTHALPGLSEQEGQ-----------KTSAATCPE-PHSFFLLFLVT 546

  Fly   620 MLFSS 624
            ::.::
Mouse   547 LVLAA 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dally	NP_001246685.1	Glypican	51..622	CDD:279494	140/586 (24%)
Gpc1	NP_057905.1	Glypican	22..538	CDD:279494	134/574 (23%)
Gpc1	NP_057905.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	477..531		18/68 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3821
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810