DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dally and Gpc5

DIOPT Version :9

Sequence 1:	NP_001246685.1	Gene:	dally / 39013	FlyBaseID:	FBgn0263930	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	XP_036014229.1	Gene:	Gpc5 / 103978	MGIID:	1194894	Length:	626	Species:	Mus musculus

Alignment Length:	645	Identity:	160/645 - (24%)
Similarity:	258/645 - (40%)	Gaps:	117/645 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 AAKHLD-----LDGIHHHQHHLHSATTHHRRRLQRDSRAKD---------AVGGST-----HQCD 70
            :|.||.     |..:....|....||    |..:.|:|...         |:.|||     ..|:
Mouse    44 SATHLPPALPMLGALESEDHSGEGAT----RTPRMDARTWRLGWRCLLLLALLGSTRSEGVESCE 104

  Fly    71 AVKSYFESIDIKSSGTYSEKGAICG------------------GNCCNNATELELRDKAAGMFEQ 117
            .|:..|:         :...||:.|                  ..||....|...:..|....:|
Mouse   105 EVRKLFQ---------WRLGGAVKGLPEAPRAGPDLQVCLSKNPTCCTRKMEERYQIAARQDLQQ 160

  Fly   118 LLHHHTSSLRGVLETNAKQFQSHVLELAQISENMTHSLFSKVYTRMVPSSRMMIHQLYTEIMNHL 182
            :|...:|:|:.::..||..||..:..|.:.:||.|..||...|..|...:...|.:.:|::..:|
Mouse   161 VLQTSSSTLKLLISRNAAAFQETLETLIRQAENYTSILFCNTYRNMALEAAASIQEFFTDVGLYL 225

  Fly   183 IYTSNYTNSNGQLGRRGIGSVQSNLEEAVRHFFVQLFPVAYHQMVHLSKNNLGDLHEDYVNCLQH 247
            .                  ....|.||.|..||..|||:.|:   ||....:.|....|..|::.
Mouse   226 F------------------GADVNPEEFVNRFFDSLFPLVYN---HLINPGVTDSSLQYSECIRM 269

  Fly   248 NFDEMHPFGDIPQQVQSNLGKSVHMSNVFMNALLQAAEVLSEADALYGEQLTDTCKLHLLKMHYC 312
            ...::.|||:||::|...:|:|:.....|:.||....||::..|.::   .:..|...||||.||
Mouse   270 ARQDVSPFGNIPKRVMGQMGRSLLPGRTFLQALNLGIEVINTTDHIH---FSKECSRALLKMQYC 331

  Fly   313 PNCNGHHSSSRSETKLCYGYCKNVMRGCSAEYAGLLDSPWSGVVDSLNNLVTTHILSDT-----G 372
            |:|     .|...:|.|.|||.||:|||.|.... |:..|...:.||..      |||.     .
Mouse   332 PHC-----QSLMLSKPCMGYCLNVIRGCLAHMTE-LNPHWHAYIRSLEE------LSDAMHGTYD 384

  Fly   373 IINVIKHLQTYFSEAIMAAMHNGPELEKKVKKTCGTPSLTPYSSGEPDARPPPHKNNVKWATDPD 437
            :.:|:.:.....::|::.|..||.:|..:|...||.|..||..|......|...|:.:|.:....
Mouse   385 VEHVLLNFHLLVNDAVLQAHLNGQKLLDQVNTICGHPVRTPTQSPRCTFDPSKEKHGMKISARNG 449

  Fly   438 PGMVL-----FLSTIDKSKEFYTTIVDNFCDEQQHSRDDHSCWSGDRF-GDYTQLLINPGTDSQR 496
            ...:.     |::::.....||..:.|..|..:..:.:...||:|:.. ..|.|.::..|..:|.
Mouse   450 EETLANRRKEFINSLRLHGSFYGGLADQLCVNELAAPEGRPCWNGEEIVKSYAQRVVGNGIKAQS 514

  Fly   497 YNPEVPFNAKAQTGKLNELVDKLFKIRKSIGAAAPS-NSIQATHDIQNDMGEGSGGG--EGQIGD 558
            .||||  ..:.....:|:::|||..:.:.:...:|. |..:.       :..|||||  |...||
Mouse   515 ANPEV--RVRGTDPVVNQIIDKLKHVIQLLRGRSPKPNKWEL-------LQPGSGGGMLENSSGD 570

  Fly   559 DEEEYGGAHGSGDGSGDGPHTPIEESEGTTTNEVESRDSGKTSGSNPLEG----TATWML 614
            .::|.|   ..|.|||:...| ::.:..:.......:...||.|.....|    |..|:|
Mouse   571 CDDEDG---CGGSGSGEVKRT-LKITNFSCHKTSLEKACHKTKGHQRAGGCVSLTTEWLL 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dally	NP_001246685.1	Glypican	51..622	CDD:279494	152/614 (25%)
Gpc5	XP_036014229.1	Glypican	93..592	CDD:395918	142/556 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837935
Domainoid	1	1.000	169	1.000	Domainoid score	I3796
eggNOG	1	0.900	-	-		E1_KOG3821
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H3285
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7032
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003365
OrthoInspector	1	1.000	-	-		oto93858
orthoMCL	1	0.900	-	-		OOG6_109158
Panther	1	1.100	-	-	O	PTHR10822
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4978
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.650