DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dally and gpc6b

DIOPT Version :9

Sequence 1:	NP_001246685.1	Gene:	dally / 39013	FlyBaseID:	FBgn0263930	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_001274470.1	Gene:	gpc6b / 100331176	ZFINID:	ZDB-GENE-130515-2	Length:	543	Species:	Danio rerio

Alignment Length:	608	Identity:	142/608 - (23%)
Similarity:	237/608 - (38%)	Gaps:	149/608 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 CDAVK-SY----FESIDIKSSGTYSEKGAICG--GNCCNNATELELRDKAAGMFEQLLHHHTSSL 126
            |..|| :|    |.|.|:.:..|..|...:|.  ..|||...|.....:::..|::|:...:..|
Zfish    21 CSLVKDAYSALGFSSDDVPAEQTSGEDLRVCAPLEACCNTQMEESFSHRSSHDFQKLMDDASEEL 85

  Fly   127 RGVLETNAKQFQSHVLELAQISENMTHSLFSKVYTRMVPSSRMMIHQLYTEIMNHLIYTSNYTNS 191
            |....:..|:|....|||.:.:|...:.:|.:.|.:....:..:...|::|:...      ||..
Zfish    86 RDTFMSGHKRFDDFFLELLESAERSLNEMFVRTYGKPYLQNAEVFQSLFSELRRF------YTGG 144

  Fly   192 NGQLGRRGIGSVQSNLEEAVRHFFVQLFPVAYHQMVHLSKNNLGDLHEDYVNCLQHNFDEMHPFG 256
            |            .||||.::.|:.:|....:..:     |:...:.::|:.|:....:::.|||
Zfish   145 N------------VNLEEMLKDFWTRLLERMFQLL-----NSQFQITDEYLECIGKYTEQLRPFG 192

  Fly   257 DIPQQVQSNLGKSVHMSNVFMNALLQAAEVLSEADALYGEQLTDTCKLHLLKMHYCPNCNGHHSS 321
            |:|::::|.:.::...:..|:..|....:|   |:.:....::.:|.....||.||..|.|..:
Zfish   193 DVPKKLKSQVTRAFIAARTFVQGLAVGRDV---ANRVAQVSMSSSCVSGFTKMLYCSYCQGLFT- 253

  Fly   322 SRSETKLCYGYCKNVMRGCSAEYAGLLDSPWSGVVDSLNNLVTTHILSDTGIINVIKHLQTYFSE 386
                .|.|..||.|||:||.|..|. |::.||..:|:| .|:|..:.....|.:|::.:....||
Zfish   254 ----LKPCRNYCLNVMKGCLANQAD-LNNEWSKFIDAL-LLLTERLEGPFNIESVMEPIDVKISE 312

  Fly   387 AIMAAMHNGPELEKKVKKTCGTPS------------------LTPY------SSGEPDARPPPHK 427
            |||....|..:|..:|.:.||.|.                  ..||      :||.|..|
Zfish   313 AIMNMQENSMQLSYQVFQGCGQPEPAGMTRSARSVHDSFSGRFKPYEELPTVASGAPLHR----- 372

  Fly   428 NNVKWATDPDPGMVLFLSTIDKSKE-------FYTTIVDNFCDEQQHSRD----DHSCWSGDRFG 481
                              .:.:.||       |:.::...||.::|.|.|    |..||:|...|
Zfish   373 ------------------LVSEMKEKLKHFQSFWVSLPLVFCKDEQISADGQTEDQQCWNGHHSG 419

  Fly   482 DYTQLLINPGTDSQRYNPEVPFNAKAQTGKLNELVDKLFKIRKSIGAAAPSNSIQ----ATHDIQ 542
            .|...:...|...|..||||                       |:..:.|.:.|:    |...:.
Zfish   420 RYIAEVQKDGLAQQASNPEV-----------------------SVDVSRPDSLIRQQILALRIMS 461

  Fly   543 NDMGEGSGGGEGQIGDDEEEYGGAHGSGDGSGDG-------------PHTPIEESEGTTTNEVES 594
            |.:.....|.:....|..||     .||.|||.|             .|||:.::|  ||:||.:
Zfish   462 NKLKNAYDGHDINFQDSNEE-----SSGSGSGSGCMESCVTASDSSITHTPVPKAE--TTDEVAT 519

  Fly   595 RDSGKTSGSNPLEGTATWMLLTL 617
                ....::.||.....:.|||
Zfish   520 ----AADSASALEICTLMLTLTL 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dally	NP_001246685.1	Glypican	51..622	CDD:279494	142/608 (23%)
gpc6b	NP_001274470.1	Glypican	4..526	CDD:279494	137/594 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910