DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fhos and DIAPH3

DIOPT Version :9

Sequence 1:NP_001163387.2 Gene:Fhos / 39004 FlyBaseID:FBgn0266084 Length:2528 Species:Drosophila melanogaster
Sequence 2:NP_001035982.1 Gene:DIAPH3 / 81624 HGNCID:15480 Length:1193 Species:Homo sapiens


Alignment Length:1248 Identity:252/1248 - (20%)
Similarity:408/1248 - (32%) Gaps:439/1248 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  1398 NADAELVIYATSL-INKTLAGLNDQDSFYDESDLLEQQGMETVIQRYMSKPGTDLDLLDQL---Q 1458
            :||..||....|| ::.|...::..:||..|       |:           |..||:|::|   :
Human   187 SADERLVTCLESLRVSLTSNPVSWVESFGHE-------GL-----------GLLLDILEKLISGK 233

  Fly  1459 LYEAVLKFEDGESDGQRLPQNSMRKTQRYRPGANTTERRKSRRHSTDNSPASLTKV-------LP 1516
            :.|.|:|            :|..:..|..:...| |:....|..|.:.|.:.|.|.       :.
Human   234 IQEKVVK------------KNQHKVIQCLKALMN-TQYGLERIMSEERSLSLLAKAVDPRHPNMM 285

  Fly  1517 TTVLRMTPTQATVDEDS------SGSTNSTEFSGGLFNEKKPRDGAGVTPGLRRRRERAERHKSF 1575
            |.|:::......|.|:|      ...|::.|       |||......:..||        ||.|.
Human   286 TDVVKLLSAVCIVGEESILEEVLEALTSAGE-------EKKIDRFFCIVEGL--------RHNSV 335

  Fly  1576 LKEQQEAAANGIFAALEQREGLGQIVTAIPATIQTGDSPPQ-----SLQHEVPPCNNISGITNIS 1635
               |.:.|...:..||         ||          ||..     .:::|...|    |:..| 
Human   336 ---QLQVACMQLINAL---------VT----------SPDDLDFRLHIRNEFMRC----GLKEI- 373

  Fly  1636 NNNVSNLSC--NDTPNNSLLVMSPSKQ--LLTGSHSISIINNSFDKASNNNQSEFLTKKN----- 1691
               :.||.|  ||..:..|.|....|:  |...||.:..|....|:|.:.....:.|.|.     
Human   374 ---LPNLKCIKNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEG 435

  Fly  1692 ----------------LFRERNSTVINGIMKNI------QQTDSAYKK----------------- 1717
                            ..|::...:|:..:..|      ...|..|:|                 
Human   436 YFISILQHLLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQA 500

  Fly  1718 ----YENEANRL-NNYYSQSPKHQIHQ-PIQPTPEVLLSPKKTLNASGFDFTPAPLSSTPVKCDV 1776
                :|.:|:.| ..:..:...||..| .:|.....:...:..|.|....|     .:.|..|::
Human   501 KLEEFEEKASELYKKFEKEFTDHQETQAELQKKEAKINELQAELQAFKSQF-----GALPADCNI 560

  Fly  1777 PPEPEPLSPVKKPAAAPPPP-------PPPPPPPPPPPGWWHAPIYNSPQARTLTSTNPELLPHP 1834
            |..|.........|..||||       |||||||||||                           
Human   561 PLPPSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPPPP--------------------------- 598

  Fly  1835 VDPSDMESEDQQLLLQLKRDHTVKDLTQKLSNLPMSPTQDSANRALVGDMSGLISKAKEGLAKSK 1899
                                            ||                               
Human   599 --------------------------------LP------------------------------- 600

  Fly  1900 SKGEISRSSSVDQDVKKSEPKKSENELHWEELVRNMTRPLNLCDLDFTDLRDDDEKDVLAPRSLG 1964
                                              .|..|.                         
Human   601 ----------------------------------GMRMPF------------------------- 606

  Fly  1965 AGIPPPPPP---LGGAIAPP-PMMPPSLAP-----PPMYGYGGSLTNSVNSLNGSINGELVNGNN 2020
            :|..|||||   |||..:|| |::|..|.|     |.:         |:..||..          
Human   607 SGPVPPPPPLGFLGGQNSPPLPILPFGLKPKKEFKPEI---------SMRRLNWL---------- 652

  Fly  2021 TIKKNKKTVKLFWKEVREDMIPQVVGKTIWDELPDANVDTQ-KLEHLF-----ESRAKDLMTKKQ 2079
            .|:.::.|...||.:|.|:..              .|||.. |||:.|     |.|.::.:.:|:
Human   653 KIRPHEMTENCFWIKVNENKY--------------ENVDLLCKLENTFCCQQKERREEEDIEEKK 703

  Fly  2080 QELNKSKEIIVLDHKRSNAINIAITKLPPP-RAIKTAILKMDATVVTREGIDKLLNMLPTDEERG 2143
            ....|.||:..||.|.:..::|.::....| ..|:..||::|.|.:....|..|:..||..|:..
Human   704 SIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDETRLAESMIQNLIKHLPDQEQLN 768

  Fly  2144 KIQE--AQLSNPELPLGSAEQFLLTLASISELEARLKLWAFRLDFDNSEKEIAEPLMDLKQGIEI 2206
            .:.:  ::.||    |...|||::.::::..|..||....|:|.|:.....|...:|.:....|.
Human   769 SLSQFKSEYSN----LCEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEE 829

  Fly  2207 LRQNRTFRSILSTLLSVGIFLN----GAPVKGFQIEYLAKVPEVKDTVHKHSLLHHLCHMVMESS 2267
            ::::::|..:|..:|.:|.::|    .|...||.:..|.|:.:.|....|.:|||.|..:..|..
Human   830 IKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKY 894

  Fly  2268 SDTSDLYSEIGPITRASKADFTDLAHNLNQLEAECKACWDRLKLIAKHDCPPP--LKQKLVD--- 2327
            .|..:...::.|:.:|||.....|..||.|:..:.:.....|:..     |||  |..|.|.   
Human   895 PDILNFVDDLEPLDKASKVSVETLEKNLRQMGRQLQQLEKELETF-----PPPEDLHDKFVTKMS 954

  Fly  2328 -FLADCAERIIILQIVHRRVMNRYRKFLLWLGMPQHSVAESRPNEFCRTLSEFALEYRTT-RERV 2390
             |:....|:...|..:|..:...|:..   :|.....|.:....:|...|:.|    ||| .:.:
Human   955 RFVISAKEQYETLSKLHENMEKLYQSI---IGYYAIDVKKVSVEDFLTDLNNF----RTTFMQAI 1012

  Fly  2391 QQQLEKKANHRERNKTRGKLIIDMAKFKTKDDVADDELKKLLDTSSADQADGTLTWRRRRAEQLR 2455
            ::.::|:  ..|..:.|.::..::|:                               |.|.|  |
Human  1013 KENIKKR--EAEEKEKRVRIAKELAE-------------------------------RERLE--R 1042

  Fly  2456 SPITRQSEEQFTDGD-----DEILESLVKTATKAPGTRTTPRERKRTRHADRKSLRRTL------ 2509
            ....::..|..|:||     |.:||:|...|......:.||..:...:.....|.|..|      
Human  1043 QQKKKRLLEMKTEGDETGVMDNLLEALQSGAAFRDRRKRTPMPKDVRQSLSPMSQRPVLKVCNHE 1107

  Fly  2510 --KNGLTEEEKQH 2520
              |..|||..:.|
Human  1108 NQKVQLTEGSRSH 1120

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FhosNP_001163387.2 FH2 2020..2384 CDD:280362 92/382 (24%)
CSRNP_N 2357..>2451 CDD:292638 13/94 (14%)
DIAPH3NP_001035982.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..57
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9Z207 36..60
Drf_GBD 115..297 CDD:283920 30/140 (21%)
Drf_FH3 305..488 CDD:283917 44/227 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 558..622 31/212 (15%)
FH2 636..1008 CDD:280362 99/420 (24%)
Nuclear export signal. /evidence=ECO:0000250|UniProtKB:Q9Z207 1184..1193
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1924
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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