Protein Alignment Fhos and FHOD3

DIOPT Version :9

• Sequence 1: NP_001163387.2
• Gene: Fhos / 39004
• FlyBaseID: FBgn0266084
• Length: 2528
• Species: Drosophila melanogaster
• Sequence 2: XP_011524491.1
• Gene: FHOD3 / 80206
• HGNCID: 26178
• Length: 1642
• Species: Homo sapiens
• Alignment Length: 1701
• Identity: 631/1701 - (37%)
• Similarity: 832/1701 - (48%)
• Gaps: 438/1701 - (25%)

  Fly  1175 VEWLD-----NGSNFYEPPE-------------------QRQHQPPRRIDDAAIQVYKDGDYGAY 1215
            |::||     |.:||.||..                   .|..|.|.::||..:|:..:   |||
Human     8 VQFLDDTDPFNSTNFPEPSRPPLFTFREDLALGTQLAGVHRLLQAPHKLDDCTLQLSHN---GAY 69

  Fly  1216 LDLESSLAEQAEEIEG----VNVSRKNSLVVRTQLNVRVQAIIEKLLSAQGSDLRRALFSLKQVF 1276
            ||||::||||.:|:||    ....:|:|:::||||:|||.|.||||.::.|.|||||||||||:|
Human    70 LDLEATLAEQRDELEGFQDDAGRGKKHSIILRTQLSVRVHACIEKLYNSSGRDLRRALFSLKQIF 134

  Fly  1277 QEDKDLVHAFVALGGLNCLVRVGNCADQNYQNYILRALGQVMLYVDGMNGVMKHEPTMQWLYSLI 1341
            |:||||||.||...||.||::||..|||||||||||||||:||||||||||:....|:||||:||
Human   135 QDDKDLVHEFVVAEGLTCLIKVGAEADQNYQNYILRALGQIMLYVDGMNGVINRNETIQWLYTLI 199

  Fly  1342 ASNYRSVVKTALKLLLVFVEYAESNCYVLVSAIHAVDASQGTLPWSNIMRLLKDYDNADAELVIY 1406
            .|.:|.|||||||||||||||:|||..:|:.|:.|||..:|..||||||.:|::.|..|.||::|
Human   200 GSKFRLVVKTALKLLLVFVEYSESNAPLLIQAVTAVDTKRGVKPWSNIMEILEEKDGVDTELLVY 264

  Fly  1407 ATSLINKTLAGLNDQDSFYDESDLLEQQGMETVIQRYMSKPGTDLDLLDQLQLYEAVLKFEDGES 1471
            |.:|:||||:||.|||:|||..|.||:.|:..|.||:::|.||||||::||.:||..|:.|||:.
Human   265 AMTLVNKTLSGLPDQDTFYDVVDCLEELGIAAVSQRHLNKKGTDLDLVEQLNIYEVALRHEDGDE 329

  Fly  1472 DGQRLPQ--NSMRKTQRYRPGANT---TERRKSRRHSTDNSPASLTKVLPTTVLRMTPTQATVDE 1531
            ..:..|.  ...|:......|...   .:||:|||||..:..::|
Human   330 TTEPPPSGCRDRRRASVCSSGGGEHRGLDRRRSRRHSVQSIKSTL-------------------- 374

  Fly  1532 DSSGSTNSTEFSGGLFNEKKPRDGAGVTPGLRRRRERAERHKSFLKEQQEAAANGIFAALEQRE- 1595
              |..|:....|...|...:.||       ||.:.|..|..:...:...|          |:||
Human   375 --SAPTSPCSQSAPSFKPNQVRD-------LREKEEEEEEEQPITEPSSE----------EERED 420

  Fly  1596 -----GLGQIVTAIPATIQTG-DSPPQSLQHEVPPCNNIS------------GITNISNNNVSNL 1642
                 |....|.|......|| |:.|:|  ..:|..:|.|            |.|..|.::.|..
Human   421 DASCQGKDSKVGAASGQSPTGRDAAPKS--SALPAVSNASSQGKPLLVGTAGGTTWHSGSSGSEA 483

  Fly  1643 SCNDTPNNSLLVMSPS-----KQLLTGSHSIS--------IINNSFDKASNNNQSEFLTKKNLFR 1694
                ||  |.|:..|:     .....||..:|        :.::.|...|.:.:...|:.|.  :
Human   484 ----TP--SALLSPPASAARPSSATPGSLKVSPTIDKLPYVPHSPFHLFSYDFEDSSLSTKE--K 540

  Fly  1695 ERNSTVINGIMKNIQQTDS-----------------AYKKYENEANRLNNYYSQSPKHQIHQPIQ 1742
            |..|      .|....:||                 :..:|.|..|  |:|:|..|......|..
Human   541 EAES------QKENSSSDSFSLSTYSASEPYHFRSFSSNRYSNFGN--NSYHSSRPSSGSSVPTT 597

  Fly  1743 PT---------------------------PEVL--LSPKKTLNAS-------------------- 1758
            ||                           |:.|  .||...|.:|
Human   598 PTSSVSPPQEARLERQKSETRRPEAFSDFPQALPRSSPSGLLTSSFRQHQESLAAERERRRQERE 662

  Fly  1759 ------------------------------------------------------------GFDFT 1763
                                                                        ..|.|
Human   663 ERLQRIEREERNKFSRDYLDKREEQRQAREERYKYLEQLAAEEHEKELRSRSVSRGRADLSLDLT 727

  Fly  1764 P-------APLSSTPVKCD-----VPPEPEPLSPVKKPAAAPPPPPPPPPPPPPPPGWWHA---- 1812
            .       ||||.:|...|     ......|.:|....|:|..|.|.....|....|....
Human   728 SPAAPACLAPLSHSPSSSDSQEALTVSASSPGTPHHPQASAGDPEPESEAEPEAEAGAGQVADEA 792

  Fly  1813 -----------------PIYNSPQAR-----------------------------TLTSTNPE-- 1829
                             .:...|:.|                             ||.....|
Human   793 GQDIASAHEGAETEVEQALEQEPEERASLSEKERQNEGVNERDNCSASSVSSSSSTLEREEKEDK 857

  Fly  1830 --------LLPHPV-----------------------------DPSDMESEDQQLLLQLKRDHTV 1857
                    |.|..|                             .|.|.|..|.:.....:....|
Human   858 LSRDRTTGLWPAGVQDAGVNGQCGDILTNKRFMLDMLYAHNRKSPDDEEKGDGEAGRTQQEAEAV 922

  Fly  1858 KDLTQKLSNLPM-SPTQD-SANRALVG--DMSGLISKAKEGLAKSKSKGEISRSS-SVDQDVKKS 1917
            ..|..::|.|.. |.||| |..|..||  |..|.:    :..|:..:.|::.|.| |.|.:....
Human   923 ASLATRISTLQANSQTQDESVRRVDVGCLDNRGSV----KAFAEKFNSGDLGRGSISPDAEPNDK 983

  Fly  1918 EPK------KSENELHWEELVRNMTRPLNLCDLDFTDLRDDDEKDVL----------------AP 1960
            .|:      |:|::..|::|:.| .|.|.:.|:|||||.::|:.|||                .|
Human   984 VPETAPVQPKTESDYIWDQLMAN-PRELRIQDMDFTDLGEEDDIDVLDVDLGHREAPGPPPPPPP 1047

  Fly  1961 RSLGAGIPPPPPPLGGAIAPPPMMPPSLAPPPMYGYGGSLTNSVNSLNGSINGELVNGNNTIKKN 2025
            ..||.. |||||||..:|.|||:....|.|||      .:.|:...|..|   ::..|..|..|.
Human  1048 TFLGLP-PPPPPPLLDSIPPPPVPGNLLVPPP------PVFNAPQGLGWS---QVPRGQPTFTKK 1102

  Fly  2026 KKTVKLFWKEVREDMIP----QVVGKTIWDELPDANVDTQKLEHLFESRAKDL-MTKKQQELNKS 2085
            |||::|||.|||....|    :...:.:|.:|....|||.:|||||||::|:| ::||.....|.
Human  1103 KKTIRLFWNEVRPFDWPCKNNRRCREFLWSKLEPIKVDTSRLEHLFESKSKELSVSKKTAADGKR 1167

  Fly  2086 KEIIVLDHKRSNAINIAITKLPPPRAIKTAILKMDATVVTREGIDKLLNMLPTDEERGKIQEAQL 2150
            :||||||.||||||||.:|.|||||.||.|||..|...:.:|||:|:|.|:|||||:.|||||||
Human  1168 QEIIVLDSKRSNAINIGLTVLPPPRTIKIAILNFDEYALNKEGIEKILTMIPTDEEKQKIQEAQL 1232

  Fly  2151 SNPELPLGSAEQFLLTLASISELEARLKLWAFRLDFDNSEKEIAEPLMDLKQGIEILRQNRTFRS 2215
            :|||:||||||||||||:|||||.|||.||||::|::.:|||:||||:|||:||:.|..|:|...
Human  1233 ANPEIPLGSAEQFLLTLSSISELSARLHLWAFKMDYETTEKEVAEPLLDLKEGIDQLENNKTLGF 1297

  Fly  2216 ILSTLLSVGIFLNGAPVKGFQIEYLAKVPEVKDTVHKHSLLHHLCHMVMESSSDTSDLYSEIGPI 2280
            ||||||::|.||||...|.|::.||.|||||||||||.|||||:|.||:|:..|:||||||||.|
Human  1298 ILSTLLAIGNFLNGTNAKAFELSYLEKVPEVKDTVHKQSLLHHVCTMVVENFPDSSDLYSEIGAI 1362

  Fly  2281 TRASKADFTDLAHNLNQLEAECKACWDRLKLIAKHDCPPPLKQKLVDFLADCAERIIILQIVHRR 2345
            ||::|.||..|..||.|:|..|||.||.||.||||:..|.|||::.:||.|||||||||:|||||
Human  1363 TRSAKVDFDQLQDNLCQMERRCKASWDHLKAIAKHEMKPVLKQRMSEFLKDCAERIIILKIVHRR 1427

  Fly  2346 VMNRYRKFLLWLGMPQHSVAESRPNEFCRTLSEFALEYRTTRERVQQQLEKKANHRERNKTRGKL 2410
            ::||:..|||::|.|.:::.|...|:|||.:||||||||||||||.||.:|:||||||||||||:
Human  1428 IINRFHSFLLFMGHPPYAIREVNINKFCRIISEFALEYRTTRERVLQQKQKRANHRERNKTRGKM 1492

  Fly  2411 I--------IDMAKFKTK--------------DDVADDE-LKKLLDTSSADQADGTLTWRRRRAE 2452
            |        ::..||...              :|.|:.| :|.:|.|||....|.|.....|
Human  1493 ITDTDEEEEVESGKFSGSSPAPPSQPQGLSYAEDAAEHENMKAVLKTSSPSVEDATPALGVR--- 1554

  Fly  2453 QLRSPITRQSEEQFT-----------DGDDEILESLVKTATKAPGTRTTPRERKRTRHADRKSLR 2506
             .||..:|.|...:|           |..|||::.:||:||:.|..|..||||||:| |:|||||
Human  1555 -TRSRASRGSTSSWTMGTDDSPNVTDDAADEIMDRIVKSATQVPSQRVVPRERKRSR-ANRKSLR 1617

  Fly  2507 RTLKNGLTEEE 2517
            ||||:|||.||
Human  1618 RTLKSGLTPEE 1628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fhos	NP_001163387.2	FH2	2020..2384	CDD:280362	220/368 (60%)
		CSRNP_N	2357..>2451	CDD:292638	50/116 (43%)
FHOD3	XP_011524491.1	FH2	1095..1466	CDD:280362	221/370 (60%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	442	1.000	Domainoid score	I546
eggNOG	1	0.900	-	-		E1_KOG1924
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	952	1.000	Inparanoid score	I338
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003497
OrthoInspector	1	1.000	-	-		otm42051
orthoMCL	1	0.900	-	-		OOG6_104165
Panther	1	1.100	-	-	O	PTHR45920
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3293
SonicParanoid	1	1.000	-	-		X2390
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.890