Protein Alignment Fhos and fhod3a

DIOPT Version :10

• Sequence 1: NP_001163387.2
• Gene: Fhos / 39004
• FlyBaseID: FBgn0266084
• Length: 2528
• Species: Drosophila melanogaster
• Sequence 2: XP_021323896.1
• Gene: fhod3a / 564742
• ZFINID: ZDB-GENE-060503-633
• Length: 1557
• Species: Danio rerio
• Alignment Length: 1601
• Identity: 622/1601 - (38%)
• Similarity: 840/1601 - (52%)
• Gaps: 318/1601 - (19%)

  Fly  1175 VEWLD-----NGSNFYEPPE-------------------QRQHQPPRRIDDAAIQVYKDGDYGAY 1215
            |::||     |.:||.||..                   .|..:.|.::||.|:|:..:   |.|
Zfish     8 VQFLDDTDPFNSTNFPEPTRPPVYTFREDIPVINQIAGVHRLLKAPHKLDDCALQLSHN---GVY 69

  Fly  1216 LDLESSLAEQAEEIEG------VNVSRKNSLVVRTQLNVRVQAIIEKLLSAQGSDLRRALFSLKQ 1274
            |||||:|.||.:|:||      ....:|:|:::||||:|||.|.||||.::.|.|||||||||||
Zfish    70 LDLESTLDEQRDELEGFQQDDCAGRGKKHSVILRTQLSVRVHACIEKLYNSNGRDLRRALFSLKQ 134

  Fly  1275 VFQEDKDLVHAFVALGGLNCLVRVGNCADQNYQNYILRALGQVMLYVDGMNGVMKHEPTMQWLYS 1339
            :||:||||||.||...||.||::||..|||||||||||||||:||||||||||:.|..::||||.
Zfish   135 IFQDDKDLVHEFVMAEGLTCLIKVGAEADQNYQNYILRALGQIMLYVDGMNGVIGHNESIQWLYQ 199

  Fly  1340 LIASNYRSVVKTALKLLLVFVEYAESNCYVLVSAIHAVDASQGTLPWSNIMRLLKDYDNADAELV 1404
            ||.|.:|.||||:||||||||||:|||..:|:.||..||..:|...|||.|.:|.:.|..|.||:
Zfish   200 LIGSKFRLVVKTSLKLLLVFVEYSESNAALLIQAIDTVDNKRGCKSWSNAMEILAEKDGVDTELL 264

  Fly  1405 IYATSLINKTLAGLNDQDSFYDESDLLEQQGMETVIQRYMSKPGTDLDLLDQLQLYEAVLKFEDG 1469
            :|..:|||||||.|.|||||||..|:||:||||:|.|||:.:.|||||||:||.:|||.|:.|||
Zfish   265 VYVMTLINKTLAALPDQDSFYDMVDVLEEQGMESVSQRYLGRKGTDLDLLEQLNIYEATLRHEDG 329

  Fly  1470 ESDGQRLPQNSMRKTQR------YRPGANTTERRKSRRHSTDN-------SPAS----LTKVL-- 1515
            :.||  ||.:..|:.:|      .|.|   .|||:|||||...       ||||    ..|::
Zfish   330 DEDG--LPPSCGRRDRRRSSVGGERRG---LERRRSRRHSLGRPGHASPLSPASPHRTNIKLMNG 389

  Fly  1516 --PTTVLRMTPTQATVDEDSSGSTNSTEFSGGLFNEKKPRDGAGVTPGLRR------RRERAERH 1572
              ..|:|:........:::....|..||  .|..|.....|..|:.|....      :.....:|
Zfish   390 QDERTLLKHECLPVIEEDEDEEETPVTE--SGSDNNDDDDDEGGINPSHHSVISGSGKSSLCNKH 452

  Fly  1573 KSFLKEQQEAAANGIFAA-LEQREGLGQIV------TAIPATIQTGDSPPQ-------------- 1616
            .:..:|::.|.::.:..| ..|...|..::      ..:|:|.|.  ||||
Zfish   453 TTEEEEKKRATSSALPPADSAQPSVLANLLARRRSSVTVPSTNQI--SPPQRPLDRLPYLPHSPF 515

  Fly  1617 -------SLQHEVPPCNNISGITNISNNNVSNLSCNDTPNNSLLVMSPSKQ----LLTGSHSISI 1670
                   ..|.|.|           ...|..:||...:|:      :|:||    .|.|     :
Zfish   516 FLFSYDMEEQEEKP-----------DEKNSRSLSAVGSPS------TPTKQNERPALGG-----L 558

  Fly  1671 INNSFDKASNNNQSEFLTKKNLFRERNSTVINGIMKNIQQTDSAYKKYENEANRLNNYYSQSPKH 1735
            :::|:.:...:..:|        ||:         :.:|:.:...:....|.||.:..|..:.:.
Zfish   559 LSSSYRQHQESLAAE--------REK---------RRVQREERLQRIEREERNRHSRDYVSNMEE 606

  Fly  1736 QIHQPIQ--PTPEVLLS---------------PKKTLNASGFDFTPAPLSS-----TPVKCDVPP 1778
            ..|...:  .|.|.|.:               |..|..:|. ..||:.::|     ||:....|.
Zfish   607 ARHAREERFKTAERLAAEEFERERQRSAPRGLPTDTCQSSR-SATPSSVTSQEEQDTPIASYPPS 670

  Fly  1779 EPE--PLSPVKKPAAAPPPPPPPPPPPPPPPGWWHAPIYNSPQARTLTSTNPELLPHPVDPS--- 1838
            ||:  .|.|..:....|....|...............:.....|....|...|.:....:.|
Zfish   671 EPDTNDLEPEAEADLEPEEKKPTEEAEEEVEEEVEEEVEEGVSAEPEVSAAEEQVAEEEEESERE 735

  Fly  1839 --DMESEDQQLLLQLKRDH---TVKDLTQKLSNLPMSPTQDSANRALVG---------------- 1882
              |.|:||..:|...:|.:   ..||.....|....|.|.:..:|...|
Zfish   736 APDGEAEDSGILSDKERQNEEVNEKDNCSASSISSASSTLEREDRLNAGAADTGQWNVNEQRHKI 800

  Fly  1883 --------DMSGLISKAK----------EGLAKSK-SKGEISR-----SSSVDQDV---KKSE-- 1918
                    ||  |.|::|          |.||:.| :.||...     :::.|::.   ||.|
Zfish   801 LDSKLFMLDM--LYSQSKKPCEEDEDEDEELAEDKEADGEEKEPDEDSATAPDENTEADKKQETQ 863

  Fly  1919 ----------------------------------PKKSENELHWEELVRNMTRPLNLCDLDFTDL 1949
                                              |.|.|::..|::|:.: .|.|.:.|:|||||
Zfish   864 SNVRAFAERFGDVVKGLTSPPIELQDLPPPPPPPPPKKESDCIWDQLMAS-PRDLRIGDIDFTDL 927

  Fly  1950 RDDDEKDVLAPRSLGA-----GIPPPPPPLGGAI-APPPMM--PPSLAPPPMYGYGGSLTNSVNS 2006
            .|:|::|||...||.:     ..||||||....: |||||.  ||   |||::...........|
Zfish   928 GDEDDQDVLDSGSLYSSGDLQAPPPPPPPCPFNLPAPPPMFGCPP---PPPVFSIRVPPPPPCFS 989

  Fly  2007 LNGSINGELVNGNNTIKKNKKTVKLFWKEVR-EDMI---PQVVGKTIWDELPDANVDTQKLEHLF 2067
            .......|:.......:|.|||::|||.||: .|.|   .:...:::|..|....:||.||||||
Zfish   990 NQAPPPPEMKAELPLFQKKKKTIRLFWSEVQPADWIYRNHKRSQESLWSRLEPVKIDTAKLEHLF 1054

  Fly  2068 ESRAKDL-MTKKQQELNKSKEIIVLDHKRSNAINIAITKLPPPRAIKTAILKMDATVVTREGIDK 2131
            ||::|:: :.||.....|..||||||.||||:|||.:|.|||||.|||||:..|...:.:|||:|
Zfish  1055 ESKSKEMPVAKKAAADGKRPEIIVLDSKRSNSINIGLTVLPPPRTIKTAIVNFDEYALNKEGIEK 1119

  Fly  2132 LLNMLPTDEERGKIQEAQLSNPELPLGSAEQFLLTLASISELEARLKLWAFRLDFDNSEKEIAEP 2196
            :|.|:||.||..:||||||:||::||||||||||||:|||||.|||:||||:||::.:|||:|||
Zfish  1120 ILTMIPTAEETQRIQEAQLANPDVPLGSAEQFLLTLSSISELSARLQLWAFKLDYEATEKEVAEP 1184

  Fly  2197 LMDLKQGIEILRQNRTFRSILSTLLSVGIFLNGAPVKGFQIEYLAKVPEVKDTVHKHSLLHHLCH 2261
            |.|||:|::.|.:|:|.|.||||||::|.||||:..|||.:.||.|||||||||||.|||||:|.
Zfish  1185 LQDLKEGMDQLEKNKTLRYILSTLLAIGNFLNGSNAKGFDLNYLEKVPEVKDTVHKQSLLHHVCS 1249

  Fly  2262 MVMESSSDTSDLYSEIGPITRASKADFTDLAHNLNQLEAECKACWDRLKLIAKHDCPPPLKQKLV 2326
            .|:|:.|||:|||||||.|||::|.||..|..||..:|..|||.||.||:||||:..|.||||:.
Zfish  1250 AVLENCSDTTDLYSEIGAITRSAKVDFEQLQENLTLMERRCKASWDHLKVIAKHEMKPVLKQKMS 1314

  Fly  2327 DFLADCAERIIILQIVHRRVMNRYRKFLLWLGMPQHSVAESRPNEFCRTLSEFALEYRTTRERVQ 2391
            |||.:||||||||:|||||:|||:..|||:||.|.:||.|.....|.:.:||||||||||||||.
Zfish  1315 DFLKECAERIIILKIVHRRIMNRFHSFLLFLGQPAYSVREISVTRFSKIISEFALEYRTTRERVL 1379

  Fly  2392 QQLEKKANHRERNKTRGKLIIDMAKFKTK-DDVADDELKKLLDTSSADQAD-------------- 2441
            ||.:|:|:||||||||||:|.|:   .|: ||..|.|....:..||:..|.
Zfish  1380 QQKQKRADHRERNKTRGKMITDV---NTQTDDEEDSEAAGRVCVSSSSSAPPAGPQMQVQPQPQP 1441

  Fly  2442 -------------------------GTLTWRRRRAEQLRS---PITRQSEEQFTDGDDEILESLV 2478
                                     ...|..|.||.|.||   |:..:|:....|..|||:|.:|
Zfish  1442 SQPQGLCDAEDAAEHQQMTAVLKTRDLRTRTRTRATQGRSAWAPVNEESQINTEDAADEIMERIV 1506

  Fly  2479 KTATKAPGTRTTPRERKRTRHADRKSLRRTLKNGLTEEEKQ 2519
            ::||::|..|..||||:|:| |:|||||||||.|||.||.|
Zfish  1507 RSATQSPRERAQPRERRRSR-ANRKSLRRTLKGGLTPEEAQ 1546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fhos	NP_001163387.2	Formin_GBD_N	1174..1265	CDD:465735	42/119 (35%)
		FH2	2020..2384	CDD:396655	217/368 (59%)
fhod3a	XP_021323896.1	Formin_GBD_N	5..125	CDD:465735	42/119 (35%)
		MAP7	570..>632	CDD:461709	12/78 (15%)
		FH2	1003..1372	CDD:396655	217/368 (59%)