DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fhos and Diaph3

DIOPT Version :9

Sequence 1:NP_001163387.2 Gene:Fhos / 39004 FlyBaseID:FBgn0266084 Length:2528 Species:Drosophila melanogaster
Sequence 2:NP_062644.1 Gene:Diaph3 / 56419 MGIID:1927222 Length:1171 Species:Mus musculus


Alignment Length:1573 Identity:276/1573 - (17%)
Similarity:482/1573 - (30%) Gaps:581/1573 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly  1044 DAHSER------PPPLGQCASPVRCPSPYDN----------------IPRSQLQEPPPPPTTTLT 1086
            |:.|.|      .||.|......:.|..:.|                ||.|:.:.||.|...|::
Mouse    12 DSKSSRRKGLQSAPPAGPYEPGEKRPKLHLNIRTLTDDMLDKFASIRIPGSKKERPPLPHLKTVS 76

  Fly  1087 SL-------------QPRFSPQTRRAGEKLFISRHQNIDELLGGACRPLSPLFYGNSNPAESELT 1138
            .:             .|:..|::...  |||....:::                   |..|.:..
Mouse    77 GISDSSSLSSETMENNPKALPESEVL--KLFEKMMEDM-------------------NLNEDKKA 120

  Fly  1139 PLAGKNMFLLEEVTPDQVRIHDSTAQLPVIQRMQRDVEWLDNGSNFYEPPEQRQHQPPRRIDDAA 1203
            ||..|:..:.:|:....:.....|..|    |..|.:.           |::..|:......|..
Mouse   121 PLREKDFGIKKEMVMQYINTASKTGSL----RSSRQIS-----------PQEFLHELKMGYTDER 170

  Fly  1204 IQVYKDGDYGAYLDLESSLAE------QAEEIEGVNVSRKNSLVVRTQLNVRVQAIIEKLLSAQG 1262
            :..|.:       .|..||..      |:...||:.:               :..|:|||::.| 
Mouse   171 LFTYLE-------SLRVSLTSHPVSWVQSFGHEGLGL---------------LLDILEKLINGQ- 212

  Fly  1263 SDLRRALFSLKQVFQEDKDLVHAFVALGGLNCLVRVGNCADQNYQNYILRALGQVMLYVDGMNGV 1327
                         .||.                      ..:..|:.:::.|..:|....|:..:
Mouse   213 -------------IQEK----------------------VVKKTQHKVIQCLRALMNTQYGLERI 242

  Fly  1328 MKHEPTMQWLYSLIASNYRSVVKTALKLLLVFVEYAESNCYVLVSAIHAVDASQGTLPWSNIMRL 1392
            |..:.::..|...:.....:::...:|||.......|.:  :|...:.|:.::...........:
Mouse   243 MSDKRSLSLLAKAMDPRQPAMMADVVKLLSAVCIVGEES--ILEEVLEALTSAGEERKIDRFFSI 305

  Fly  1393 LKDYDNADAELVIYATSLINKTLAGLNDQDSFYDESDLLEQQGMETVIQRYMSKPGTDLDLLDQL 1457
            ::...:....|.:....|||..:...:|.|......:...:.|::.::..........||:  ||
Mouse   306 VEGLRHNSVNLQVACMQLINALVTSPDDLDFRLHLRNEFMRCGLKEILPNLKGIKNDGLDI--QL 368

  Fly  1458 QLYEAVLKFEDGESDGQRLPQNSMRKTQRYRPGANTTERRKSRRHSTDNSPASLTKVLPTTVLRM 1522
            ::::     |..|.|                                          |.....|:
Mouse   369 KVFD-----EHKEED------------------------------------------LSEFFHRL 386

  Fly  1523 TPTQATVDEDSSGSTNSTEFSGGLFNEKKPRDGAGVTPGLRRRRERAE-------------RHKS 1574
            ...:|.:||       :::....|::..|              ..|||             |:..
Mouse   387 EDIRAELDE-------ASDVYSMLWDTVK--------------ETRAEGHFLSILQHLLLIRNDR 430

  Fly  1575 FLKEQQEAAANGIFAALEQREGLGQIVTAIPATIQTGDSPPQSLQHEVPPCNNISGITNISNNNV 1639
            |::||       .|..::  |.:.|||..     :.|..|..:.:..:.  .::|...::     
Mouse   431 FIREQ-------YFKLID--ECVSQIVLH-----RDGTDPDFTYRKRLD--LDLSQFVDV----- 474

  Fly  1640 SNLSCNDTPNNSLLVMSPSKQLLTGSHSISIINNSFDKASNNNQSEFLTKKNLFRERNSTVINGI 1704
                |.|           ..:|.......|.....|:|...::|.   |:..|  ::....||.:
Mouse   475 ----CID-----------QAKLDEWEEKASEHCKKFEKECTDHQE---TQAQL--QKREAKINEL 519

  Fly  1705 MKNIQQTDSAYKKYENEANRLNNYYSQSPKHQIHQPIQPTPEVLLSPKKTLNASGFDFTPAPLSS 1769
            ...:|    |:|         :.:.:..|..:|  |:||:.|....|..                
Mouse   520 QAELQ----AFK---------SQFGALPPGTKI--PLQPSVEGEAGPSA---------------- 553

  Fly  1770 TPVKCDVPPEPEPLSPVKKPAAAPPPPPPPPPPPPPPPGWWHAPIYNSPQARTLTSTNPELLPHP 1834
                  :||.|..||     ...|||||||||||||.||                      :|.|
Mouse   554 ------LPPAPPALS-----GGVPPPPPPPPPPPPPLPG----------------------MPMP 585

  Fly  1835 VDPSDMESEDQQLLLQLKRDHTVKDLTQKLSNLPMSPTQDSANRALVGDMSGLISKAKEGLAKSK 1899
                                                                             
Mouse   586 ----------------------------------------------------------------- 585

  Fly  1900 SKGEISRSSSVDQDVKKSEPKKSENELHWEELVRNMTRPLNLCDLDFTDLRDDDEKDVLAPRSLG 1964
                                                                           .|
Mouse   586 ---------------------------------------------------------------FG 587

  Fly  1965 AGIPPPPPP--LGGAIAPPPMMPPSLAP-----PPMYGYGGSLTNSVNSLNGSINGELVNGNNTI 2022
            ..:|||||.  |||..:.|..:|..|.|     |.:         |:..||.     |..|.|.:
Mouse   588 GPVPPPPPLGFLGGQSSIPLNLPFGLKPKKEFKPEI---------SMRRLNW-----LKIGPNEM 638

  Fly  2023 KKNKKTVKLFWKEVREDMIPQVVGKTIWDELPDANVDTQ-KLEHLF-----ESRAKDLMTKKQQE 2081
            .:|     .||.:|.|:..              .|.|.. |||:.|     |.|..:...:|:..
Mouse   639 SEN-----CFWIKVNENKY--------------ENRDLLCKLENTFCCQEKEKRNTNDFDEKKVI 684

  Fly  2082 LNKSKEIIVLDHKRSNAINIAITKLPPP-RAIKTAILKMDATVVTREGIDKLLNMLPTDEERGKI 2145
            ..:.||:..||.|.:..::|.::....| ..|:|.||::|.|.::...|..|:..||.:|:...:
Mouse   685 KKRMKELKFLDPKIAQNLSIFLSSFRVPYEKIRTMILEVDETQLSESMIQNLIKHLPDEEQLKSL 749

  Fly  2146 QEAQLSNPELPLGSAEQFLLTLASISELEARLKLWAFRLDFDNSEKEIAEPLMDLKQGIEILRQN 2210
              :|..:....|...|||.:.::::..|..||....|:|.|:.....|...:|.:....|.::::
Mouse   750 --SQFRSDYNSLCEPEQFAVVMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKS 812

  Fly  2211 RTFRSILSTLLSVGIFLN----GAPVKGFQIEYLAKVPEVKDTVHKHSLLHHLCHMVMESSSDTS 2271
            :.|..:|..:|.:|.::|    .|...||.:..|.|:.:.|....|.:|||.|..:..|..:|..
Mouse   813 KGFSKLLELVLLMGNYMNAGSRNAQTFGFDLSSLCKLKDTKSADQKTTLLHFLVDVCEEKHADIL 877

  Fly  2272 DLYSEIGPITRASKADFTDLAHNLNQLEAECKACWDRLKLIAKHDCPPP--LKQKLV----DFLA 2330
            ....::..:.:||:.....|..|:.|:..:.:.....|:..     |||  |..|.|    .|:.
Mouse   878 HFVDDLAHLDKASRVSVEMLEKNVKQMGRQLQQLEKNLETF-----PPPEDLHDKFVIKMSSFVI 937

  Fly  2331 DCAERIIILQIVHRRVMNRYRKFLLWLGMPQHSVAESRPNEFCRTLSEFALEYRTTRERVQQQLE 2395
            ...|:...|..:...:...|:..:.:..:....|:   ..||...|:.|         |....|.
Mouse   938 SANEQYEKLSTLLGSMTQLYQSIMGYYAVDMKKVS---VEEFFNDLNNF---------RTSFMLA 990

  Fly  2396 KKANHRERNKTRGKLIIDMAKFKTKDDVADDELKKLLDTSSADQADGTLTWRRRRAEQLRSPITR 2460
            .|.|.::|                  :.|:.|.:..:              .:.|||:.|  :.|
Mouse   991 LKENIKKR------------------EAAEKEKRARI--------------AKERAEKER--LER 1021

  Fly  2461 QSE-----EQFTDGD-----DEILESLVKTATKAPGTRTTPRERKRTRHADRKSLRRTL------ 2509
            |.|     |..|:||     |.:||:|...|......:.||:.:...:.....|.|..|      
Mouse  1022 QQEKKRLLEMKTEGDETGVMDSLLEALQSGAAFRDRRKRTPKLKDIRQSLSPMSQRPVLKVCNHE 1086

  Fly  2510 --KNGLTEEEKQH 2520
              |..|||..:.|
Mouse  1087 NQKMQLTEGSRPH 1099

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FhosNP_001163387.2 FH2 2020..2384 CDD:280362 86/380 (23%)
CSRNP_N 2357..>2451 CDD:292638 12/93 (13%)
Diaph3NP_062644.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..40 7/27 (26%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:19117945 16..39 5/22 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 60..95 7/34 (21%)
Drf_GBD 96..276 CDD:283920 40/273 (15%)
Drf_FH3 284..471 CDD:283917 37/272 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 532..601 36/247 (15%)
FH2 615..987 CDD:280362 94/423 (22%)
Nuclear export signal. /evidence=ECO:0000269|PubMed:19117945 1162..1171
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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