DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fhos and diaph2

DIOPT Version :9

Sequence 1:	NP_001163387.2	Gene:	Fhos / 39004	FlyBaseID:	FBgn0266084	Length:	2528	Species:	Drosophila melanogaster
Sequence 2:	XP_021336921.1	Gene:	diaph2 / 556029	ZFINID:	ZDB-GENE-090115-1	Length:	1166	Species:	Danio rerio

Alignment Length:	1551	Identity:	288/1551 - (18%)
Similarity:	489/1551 - (31%)	Gaps:	564/1551 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  1001 ASSDDEEQPVLVVINQQESRDEVDLRLAPPTL--ESQELSNSFNFDAHSERPPPLGQCASPVRCP 1063
            |..:|..:|.....::.||::: .|.:...||  :.::...||......:..|
Zfish     6 AGGEDPNKPSKKKSSEDESKNK-KLNIHIKTLADDMRDRITSFRKQGMKKEKP------------ 57

  Fly  1064 SPYDNIPRSQLQEPPPPPTTTLTSL---QPRFSPQTRRAGEKLFISRHQNIDELLGGACRPLSPL 1125
                      |.:.|..|.:|.|.|   ||.|..::....||..:...:.:.|
Zfish    58 ----------LIQHPTDPISTQTELPVPQPFFDERSMNLSEKEIVDLFEKMME------------ 100

  Fly  1126 FYGNSNPAESELTPLAGKNMFLLEEVTPDQVRIHDSTAQLPVIQRMQRDVEWLDNGSNFYEPPEQ 1190
               :.|..|....||.||::               ||.:..|:|
Zfish   101 ---DMNLNEERKAPLRGKDL---------------STKREMVVQ--------------------- 126

  Fly  1191 RQHQPPRRIDDAAIQVYKDGDYGAYLDLESSLAEQAEEIEGVNVS--RKNSLVVRTQLNVRVQAI 1253
                                          .::..|:.|.|..|:  .:||   :.:..:..|..
Zfish   127 ------------------------------YISATAKSITGSKVAGGLRNS---KHECTLSSQEY 158

  Fly  1254 IEKLLSAQGSDLRRALFSLKQVFQEDKDLVHAFVALGGLNCLVRVGNCADQN----YQNYILRAL 1314
            :.:|.|.               ..|||          .||||..:......|    ..|:....|
Zfish   159 VHELRSG---------------ISEDK----------LLNCLESLRVSLTSNPVSWVNNFGHEGL 198

  Fly  1315 GQVMLYVDGMNGVM------------KHEPTMQWLYSLIASNY--RSVVKTALKLLLVFVEYAES 1365
            |   |.:|.:..::            :|: .:|.|.:.:.:.|  :.::.....|||:
Zfish   199 G---LLLDALERLLDKKQQENIDKKNQHK-LIQCLKAFMNNKYGLQRILGDERSLLLL------- 252

  Fly  1366 NCYVLVSAIHAVDASQGTLPWSNIMRLLKDYDNADAELVIYATSLINKTLAGL------NDQDSF 1424
                    ..|:|..| |...:.|:::|      .|..:|...::::|.||.:      |:::.|
Zfish   253 --------ARAIDPKQ-TNMMTEIVKIL------SAVCIIGEENILDKILAAMTIAAERNNKERF 302

  Fly  1425 YDESDLLEQ---QGMETVIQRYMSKPGTDLDLLD-QLQLYEAVLKFEDGESDGQRLPQNSMRKTQ 1485
            ....:.||.   |.::....:.::...|..|.|| ::.|....|:
Zfish   303 APIVEGLENHEAQQLQVACMQLINALVTSPDDLDFRIHLRNEFLR-------------------- 347

  Fly  1486 RYRPGANTTERRKSRRHSTDNSPASLTKVLPTTVLRMTPTQATVDEDSSGSTNSTEFSGGLFNEK 1550
                                   ..|.|:||                ....|...:....:|||.
Zfish   348 -----------------------CGLKKILP----------------ELKETEELDIQLKVFNEN 373

  Fly  1551 KPRDGAGVTPGLRRRRERAERHKSFLKEQQEAAANGIFAALEQREGLGQIVTAIPATIQTGDSPP 1615
            |..|..          |.:.|......|..:               :|::...:...::...|.|
Zfish   374 KEEDSI----------ELSHRLDDIRAEMDD---------------MGEVYHLLSNMVKDTGSEP 413

  Fly  1616 ---QSLQHEVPPCNNISGITNISNNNVSNLSCND---TPNNSLLVMSPSKQLL---TG------- 1664
               ..|||.:                   |..||   .|....::.....|::   :|
Zfish   414 YFLSILQHLL-------------------LIRNDYYIRPQYYKVIEECVSQIVLHRSGMDPDFAY 459

  Fly  1665 --------SHSISIINNSFDKA----SNNNQSEFLTKKNLFRERNSTVINGIMKNIQQTDSAYKK 1717
                    ||   :|:...|||    |....:||..|   |.|..| ........:|:.:...|.
Zfish   460 RERLDVDFSH---LIDQCVDKAKVDESEQRAAEFSKK---FDEEFS-ARQEAQAELQKQEEKIKA 517

  Fly  1718 YENEANRLNNYYSQSPKHQIHQPIQPTPEVLLSPKKTLNASGFDFTPAPLSSTPVKCDVPPEPEP 1782
            :|::.|.|....: |.:.::.:     .|..:|.:.:..|:|    |....:.|     ||.|.|
Zfish   518 FESQINTLQAQLT-SERDKLKE-----AEKSISERNSKIAAG----PKAAGAGP-----PPPPPP 567

  Fly  1783 LSPVKKPAAAPPPPPPPPPPP----PPPPGWWHAPIYNSPQARTLTSTNPELLPHPVDPSDMESE 1843
            ...:     ||||||||||||    ||||                        |.|..|:.:.
Zfish   568 PGGI-----APPPPPPPPPPPIGGAPPPP------------------------PPPPFPASLG-- 601

  Fly  1844 DQQLLLQLKRDHTVKDLTQKLSNLPMSPTQDSANRALVGDMSGLISKAKEGLAKSKSKGEISRSS 1908
                                    |..|
Zfish   602 ------------------------PPPP------------------------------------- 605

  Fly  1909 SVDQDVKKSEPKKSENELHWEELVRNMTRPLNLCDLDFTDLRDDDEKDVLAPRSLGAGIPPPPPP 1973
                                                               |...|.|.||||||
Zfish   606 ---------------------------------------------------PPPPGCGPPPPPPP 619

  Fly  1974 LGGAIAPPPMMPPSLAPPPM-----YGYGGSLTNSVNSLNGSINGELVNGNNTIKKNKKTVKLFW 2033
            .||...|||.||.  ||||:     ||.....|...:|:...:|.      :.|...:.....||
Zfish   620 PGGGPPPPPGMPS--APPPLVVQLPYGLAPKKTYKPDSIMKRVNW------SKIVPQEMAENCFW 676

  Fly  2034 KEVREDMIPQVVGKTIWDELPDANVDTQKLEHLFESRAK-------DLMTKKQQELNKSKEIIVL 2091
            .:|:|:.....   .::.||        .|....:||.|       |.||   |...|:||:.:|
Zfish   677 LKVKEERFENT---DMFSEL--------SLSFSSKSRVKKDVEETDDRMT---QFKKKAKELRIL 727

  Fly  2092 DHKRSNAINIAITKLP-PPRAIKTAILKMDATVVTREGIDKLLNMLPTDEERGKIQEAQLSNPEL 2155
            |.|.:..::|.:.... |...|:..:|::|...::...|..|:..||..:|...:  |:|.|...
Zfish   728 DAKTAQNLSIFLGSFRLPYEEIRDIVLQVDEERLSEALIQNLIKNLPEQKELSNL--AELKNEYE 790

  Fly  2156 PLGSAEQFLLTLASISELEARLKLWAFRLDFDNSEKEIAEPLMDLKQGIEILRQNRTFRSILSTL 2220
            .|..:|||.:.::|:..|..||....|:|.|:.....|...:|::....|.::::..|..:|..:
Zfish   791 ELCESEQFGIVMSSVKMLRPRLNGILFKLTFEEQVNNIRPDIMNVTFACEEVKKSEGFHMLLEMV 855

  Fly  2221 LSVGIFLN----GAPVKGFQIEYLAKVPEVKDTVHKHSLLHHLCHMVMESSSDTSDLYSEIGPIT 2281
            |.||.::|    .|...||.|.:|.|:.:.|.|....:|||.|.....|...:......|:..:.
Zfish   856 LLVGNYMNSGSRNAQTFGFNISFLCKLRDTKSTDQNTTLLHFLAEKCEEKYPEMLKFPDELEHVE 920

  Fly  2282 RASKADFTDLAHNLNQLEAECKACWDRLKLIAK-HDCPPPLKQKLVDFLADCAERIIILQIVHRR 2345
            .|||.....|..:|:.:|...:...:.::...| .|......:|:..|.....|:...|..:|:.
Zfish   921 SASKVAAQTLKASLDIMERHIQRLENDIQNFPKTDDKQDKFVEKMSGFSKHSREQYEKLSTMHKN 985

  Fly  2346 VMNRYRKFLLWLGMPQHSVAESRPNEFCRTLSEF---------------ALEYRTTRERV-QQQL 2394
            :...|.....:.....|:|:   ..:|...|:.|               .:|.:..|.:: :::.
Zfish   986 MQKLYENLGSYFAFDPHTVS---IEDFFGDLANFRNLFMDAVRENHKKREMEEKIKRAKIAKEKA 1047

  Fly  2395 EKKANHRERNKTRGKLIIDMAKFKTKDDVADDELKKLLDTSSADQADGTLTWRRRR 2450
            |::...|::.|   |.:|||.|...:..|.|..::.|       |:......||:|
Zfish  1048 EREKIERQQKK---KQLIDMNKEGDETGVMDSLMEAL-------QSGAAFRDRRKR 1093

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fhos	NP_001163387.2	FH2	2020..2384	CDD:280362	88/391 (23%)
Fhos	NP_001163387.2	CSRNP_N	2357..>2451	CDD:292638	22/110 (20%)
diaph2	XP_021336921.1	Drf_GBD	86..276	CDD:310750	49/324 (15%)
		Drf_FH3	284..470	CDD:310747	41/291 (14%)
		FH2	647..1020	CDD:280362	90/397 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1924
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810