Protein Alignment Fhos and fhod1

DIOPT Version :10

• Sequence 1: NP_001163387.2
• Gene: Fhos / 39004
• FlyBaseID: FBgn0266084
• Length: 2528
• Species: Drosophila melanogaster
• Sequence 2: XP_021333585.2
• Gene: fhod1 / 503946
• ZFINID: ZDB-GENE-110623-4
• Length: 1441
• Species: Danio rerio
• Alignment Length: 1545
• Identity: 569/1545 - (36%)
• Similarity: 806/1545 - (52%)
• Gaps: 322/1545 - (20%)

  Fly  1175 VEWLDNG-----SNFYEP--PEQ---RQHQP--------------PRRIDDAAIQVYKDGDYGAY 1215
            |::|::.     |||.||  |.|   .:|.|              |.::::.|:|:..:|:   |
Zfish     8 VQYLEDSDPFVCSNFPEPRRPPQYDFNEHLPLNEQIAGVHKLLEAPLKLEECALQLASNGN---Y 69

  Fly  1216 LDLESSLAEQAEEIE----GVNVSRKNSLVVRTQLNVRVQAIIEKLLSAQGSDLRRALFSLKQVF 1276
            |||:||||||.:::|    .|...:|..|::||||:|||.:|:|||.::.|.:|||:||||||:|
Zfish    70 LDLDSSLAEQRDDVEQLYDDVEKGKKPILILRTQLSVRVHSILEKLYNSHGPELRRSLFSLKQLF 134

  Fly  1277 QEDKDLVHAFVALGGLNCLVRVGNCADQNYQNYILRALGQVMLYVDGMNGVMKHEPTMQWLYSLI 1341
            |:|||||..||...||.|.::||..||.||||||||||.|:||:||||||::.|..|:||||:|.
Zfish   135 QDDKDLVPEFVISEGLTCFIKVGAEADHNYQNYILRALSQIMLFVDGMNGIVNHNETVQWLYTLC 199

  Fly  1342 ASNYRSVVKTALKLLLVFVEYAESNCYVLVSAIHAVDASQGTLPWSNIMRLLKDYDNADAELVIY 1406
            .|..|.|||||||||:|||||.|||..:|:.|::.||..:|..||:.::.:|...:.:|.||:||
Zfish   200 GSLSRLVVKTALKLLIVFVEYTESNSPLLIQAVNIVDGKRGVKPWTILIDILSAKNGSDTELLIY 264

  Fly  1407 ATSLINKTLAGLNDQDSFYDESDLLEQQGMETVIQRYMSKPGTDLDLLDQLQLYEAVLKFEDGES 1471
            ..:|||||||.|.|||||||.:|.|||..||::||::|:..||:.||..|..:||..||.||||.
Zfish   265 TMTLINKTLAALPDQDSFYDVTDCLEQLEMESIIQKHMTSSGTEGDLKQQFTIYEKALKCEDGEM 329

  Fly  1472 DGQRLPQNSMRKTQRYRPGANTTERRKSRRHSTDN-SPASLTKVLPT-TVLRMTPTQATVDEDSS 1534
            | :..|  ::||.:| :...:..|.|||||.|:.| |.:|.....|| :|...:||.:.|...:|
Zfish   330 D-ETAP--NVRKDRR-KLTPSEQEGRKSRRSSSHNLSDSSFRPASPTVSVSSNSPTPSEVTRTAS 390

  Fly  1535 GSTNSTEFSGGLFNEKKPRDGAGVTPGLRRRRERAERHKSFLKEQQEAAANGIFAALEQREGLGQ 1599
            ...:.:..|        |..|:                                          .
Zfish   391 PQLSDSSSS--------PAPGS------------------------------------------P 405

  Fly  1600 IVTAIPATIQTGDSPPQSL-------------QHEVPPCNNISGITNISNNNVSNLSCNDTPNNS 1651
            ::|:..:|.....:||.:|             ||            |:..:.:|....:
Zfish   406 VLTSPSSTTSGSRTPPLALVTNGAESAAVPQQQH------------NLGRSFMSQYIAH------ 452

  Fly  1652 LLVMSPSKQLLTGSHSISIINNS-FDKAS-NNNQSEFLTKKNLFRERNSTVINGIMKNIQQTDSA 1714
               |..|::.|....||:..|:| |.:|| :...|...|......::.|..:...:...||.||.
Zfish   453 ---MGISRRRLKKERSITEENSSIFSRASFSETDSAPETPTQTTADQPSRTVGKRVFKQQQADSV 514

  Fly  1715 YKKYENEANRLNNYYS---------------------QSPKHQIHQPIQPTPEVLLSPKKTLNAS 1758
            ..:..|....:..:|:                     |....:...|.:...::.||...|.:.|
Zfish   515 CPESVNRDLPVLRHYADTFLRSLAVSEWEKTKKSSALQEKPSESEAPTETEEQISLSTTTTESIS 579

  Fly  1759 GFDFTPAPLSSTPVKCDVPPEPEPLSPVKKPAAAPPPPPPPPPPPPPPPGWWHAPIYNSPQARTL 1823
            |.:.....:|...::     :||..:.....|..               |..|.. ..:.|..||
Zfish   580 GQESQGENVSRHTLE-----QPEDTTTAHNEAEG---------------GLQHQG-STAEQHSTL 623

  Fly  1824 TSTNPELLPHPVDPSD-----MESEDQQLLLQLKRDHTVKDLTQKLSNLPMS---PTQDSANRAL 1880
            :.....::......|:     :||...:..|:   .|.::.:..:||.|..|   ||:|.:.||.
Zfish   624 SDDQRFVMDMLYSKSNTSSGALESPSLESALE---GHGIRSMAVRLSRLQSSSSQPTEDPSRRAE 685

  Fly  1881 VGDMSGLISKAKEGLAKSKSKGEISRSSSVDQDVKKSEPKKS-ENELH----------------- 1927
            :..:.|....|:..||:             :|.:||..|:.| |.|.|
Zfish   686 LESLGGTADAARARLAE-------------EQKLKKLRPQYSIEAETHSQSLEKTLMTPLSRGSQ 737

  Fly  1928 --WEELVRNMTRPLNLCDLDFTDLRDDDEKDVLAPRSLGAG----IPPPPPP---LGGAIAPPP- 1982
              |::| :..:|||.:.||||:||.::::.|||...:...|    |||||||   ||.|..|||
Zfish   738 DAWDKL-QPSSRPLRIKDLDFSDLMEEEDIDVLDIDTFDTGLSNVIPPPPPPVPGLGSAPPPPPP 801

  Fly  1983 ---------MMPPSLAPPPMYGYGGSLTN----------SVNSLNGSINGELVNG-NNTIKKNKK 2027
                     ..||...|||..|:.|..:.          |:....|........| :....|.:|
Zfish   802 PPPPGPAGLFSPPPPPPPPPPGFAGLASPPPPPPPPGGLSIPPPPGLFTTSPSQGLDPAFVKKRK 866

  Fly  2028 TVKLFWKEVREDMIPQ--VVGK-TIWDELPDANVDTQKLEHLFESRAKDL-MTKKQQELNKSKEI 2088
            ||||||||:::...|:  ..|: |:|..|...:|||.||||||||:.||| :.||..|:.|: .|
Zfish   867 TVKLFWKELKQSDSPRKCKFGRGTVWASLDKVDVDTAKLEHLFESKGKDLPVAKKGAEVKKA-AI 930

  Fly  2089 IVLDHKRSNAINIAITKLPPPRAIKTAILKMDATVVTREGIDKLLNMLPTDEERGKIQEAQLSNP 2153
            .|||.||||||||.:|.||....||:|||..|...:::|||:|:|.|.||:||:.|||||||:||
Zfish   931 SVLDPKRSNAINIGMTVLPAIHVIKSAILTFDEFAISKEGIEKILTMTPTEEEKQKIQEAQLANP 995

  Fly  2154 ELPLGSAEQFLLTLASISELEARLKLWAFRLDFDNSEKEIAEPLMDLKQGIEILRQNRTFRSILS 2218
            ::|||:||||||||:|||.|.|||:||||:|:::..||||||||.|||||:|.|.:|:||:.||:
Zfish   996 DVPLGTAEQFLLTLSSISGLTARLQLWAFKLNYETLEKEIAEPLFDLKQGMEQLAKNKTFKRILA 1060

  Fly  2219 TLLSVGIFLNGAPVKGFQIEYLAKVPEVKDTVHKHSLLHHLCHMVMESSSDTSDLYSEIGPITRA 2283
            |||::|.|||.:..|||::.||.||.|||||||:.|||||.|:.|:|:..||:||||||..|||:
Zfish  1061 TLLAIGNFLNSSRAKGFELGYLEKVTEVKDTVHRQSLLHHTCNFVVENYPDTTDLYSEIPAITRS 1125

  Fly  2284 SKADFTDLAHNLNQLEAECKACWDRLKLIAKHDCPPPLKQKLVDFLADCAERIIILQIVHRRVMN 2348
            :|.:|..|:.||.|||.:||..||.||::|||:..|.||.|:.:||.||.||||||::||||::|
Zfish  1126 AKVEFEQLSENLIQLERKCKTSWDNLKVVAKHETKPNLKNKMTEFLKDCTERIIILKVVHRRIIN 1190

  Fly  2349 RYRKFLLWLGMPQHSVAESRPNEFCRTLSEFALEYRTTRERVQQQLEKKANHRERNKTRGKLIID 2413
            |:..|||:||.|.:||.:::...||:.:||||||||||||||..|..|:|.||||.|||||||.:
Zfish  1191 RFHSFLLYLGHPSYSVRDTKVTHFCKIISEFALEYRTTRERVLTQKRKRAVHRERTKTRGKLITE 1255

  Fly  2414 MAKFK------------------TKDDVADDE---LKKLLDTSSADQADGTLTWRRRRAEQL--- 2454
            ..||.                  .:.:.|.:|   :|.||..::    |..|..|.|...::
Zfish  1256 TEKFSGAVTELSLDSSPSPVFSAVESEPAQEEHENMKNLLIANN----DNKLLRRSRAVRKILTT 1316

  Fly  2455 --------------------------RSPITRQS--------------------EEQFT---DGD 2470
                                      .||:..||                    |:..:   |..
Zfish  1317 AGDTSPVSPSLQWSDEEEPCDSDSAHTSPVESQSARDEDDEGVGRLSTHMSVAKEDSASSQDDAT 1381

  Fly  2471 DEILESLVKTATKAPGTR-TTPRERKRTRHADRKSLRRTLKNGLTEEEKQ 2519
            |||::.|||:.|:.|..| ::|:.|||:| .:|||||||||:||:.|..|
Zfish  1382 DEIMDRLVKSVTQNPTERASSPKTRKRSR-LNRKSLRRTLKSGLSVEVVQ 1430

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fhos	NP_001163387.2	Formin_GBD_N	1174..1265	CDD:465735	41/117 (35%)
		FH2	2020..2384	CDD:396655	209/367 (57%)
fhod1	XP_021333585.2	None