Protein Alignment Fhos and dia

DIOPT Version :9

• Sequence 1: NP_001163387.2
• Gene: Fhos / 39004
• FlyBaseID: FBgn0266084
• Length: 2528
• Species: Drosophila melanogaster
• Sequence 2: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Alignment Length: 1472
• Identity: 288/1472 - (19%)
• Similarity: 490/1472 - (33%)
• Gaps: 474/1472 - (32%)

  Fly  1101 EKLFISRHQNIDELLGGACRPLSPLFYGNSNPAESELTPLA-------GKNMFLLEEVTPDQVRI 1158
            :||.:|||:......||.   |..||   ..|::|:...::       |:.:.....|.|.   :
  Fly     4 KKLGMSRHEKTKSTGGGL---LDSLF---GRPSKSKGGTISSGTLAHGGRPVSADNYVVPG---V 59

  Fly  1159 HDSTAQLPVIQRMQRDVEWLDNGSNFYEPPEQRQHQPPRRIDDAAIQVYKDGDYGAYLDLESSLA 1223
            .|....:..:...:.|.::|:...:...|.::|                           |..||
  Fly    60 EDFEQYIQQLSVAELDAKFLEIIEDMNIPKDKR---------------------------EPLLA 97

  Fly  1224 EQAEEIEGV---NVSRKNSLVVRTQLNVRVQAIIEKLLSAQGSDLRRALFSLKQVFQEDKDLVHA 1285
            :..||.:.:   ::..||||  ....|.|.:..|:.:...|..:     .|..:|:|..:.|..|
  Fly    98 KSKEERQKMIMWHLKGKNSL--ERSANSRFEKPIDYVEYLQNGE-----HSTHKVYQCVESLRVA 155

  Fly  1286 FVA----------LGGLNCLVRV-----GNCADQNYQNYILRALGQVMLYVDGMNGVM---KHEP 1332
            ..:          :.|:..:.::     .|.:.:..:...:|.|..:|....|:|.|:   :|..
  Fly   156 LTSNPISWIKEFGVAGIGTIEKLLARSKNNASYEKIEFEAIRCLKAIMNNTWGLNVVLNPDQHSV 220

  Fly  1333 TMQWLYSLIASNYRSVVKTALKLLLVFVEYAESNCY------VLVSAIHAVDASQGTLPWSNIMR 1391
            .:....||.....:::.: |||||..|....|.|.|      :...|..:..||:...|..:.:
  Fly   221 VLLLAQSLDPRKPQTMCE-ALKLLASFCIVYERNGYEKVLRAITTIAATSFKASERFRPIVDAL- 283

  Fly  1392 LLKDYDNADAELVIYATSLINKTLAGLNDQDSFYDESDLLEQQGMETVIQRYMSKPGTDLDLLDQ 1456
            ...|..:...:|..::...|| ||..        ..:||..:..:...|.|        :.|.|:
  Fly   284 FASDQQDPKRDLACHSLIFIN-TLTN--------TPTDLNFRLHLRCEIMR--------MGLYDR 331

  Fly  1457 LQLYEAVLKFEDGESDGQRLPQ-----NSMRK------TQRYRPGANTTERRKSRRHSTDNSPAS 1510
            |..:..:::    .|:.:.|.|     |.:|:      .||:   .|.|..........|
  Fly   332 LDEFTKIVE----ASNNENLQQHFKIFNEIREDDFEEFVQRF---DNVTFNMDDATDCFD----- 384

  Fly  1511 LTKVLPTTVLRMTPTQATVDEDSSGSTNSTEFSGGLFNEKKPRDGAGVTPGLRRRRERAERHKSF 1575
               ||...|              :.:|:...|...|.:....||.....|...:..|
  Fly   385 ---VLKNLV--------------TDTTSEPYFLSILQHLLYIRDDFYFRPAYYQLIE-------- 424

  Fly  1576 LKEQQEAAANGIFAALEQREGLGQIVTAIPATIQTGDSPPQSLQHEVPPCNNISGITNISNNNVS 1640
                               |.:.|||      ...|...|                 |..|.|.
  Fly   425 -------------------ECISQIV------FHKGYCDP-----------------NFENRNF- 446

  Fly  1641 NLSCNDTPNNSLLVMSPSKQLLTGSHSISIINNSFDKASNNNQSEFLTKKNLFRERNSTVINGIM 1705
            |:   ||   |||:             ..|:..:  ||..:.:||...||
  Fly   447 NI---DT---SLLL-------------DDIVEKA--KAKESKRSEEYEKK--------------- 475

  Fly  1706 KNIQQTDSAYKKYENEANRLNNYYSQSPKHQIHQPIQPTPEVLLSPKKTLNASGFDFTPAPLSST 1770
              |:|.:||.::.|.:|..|.........:.:..|         ||.| |........|.|
  Fly   476 --IEQLESAKQEAEAKAAHLEEKVKLMEANGVAAP---------SPNK-LPKVNIPMPPPP---- 524

  Fly  1771 PVKCDVPPEPEPLSPVKKPAAAPPPPPPP-------PPPPPPPPGWWHAPIYNSPQARTLTSTNP 1828
            |.....||.|.|..|.:.....|||||||       |||||||||....|
  Fly   525 PGGGGAPPPPPPPMPGRAGGGPPPPPPPPMPGRAGGPPPPPPPPGMGGPP--------------- 574

  Fly  1829 ELLPHPVDPSDMESEDQQLLLQLKRDHTVKDLTQKLSNLPMSPTQDSANRALVGDMSGLISKAKE 1893
               |.|                                                 |.|
  Fly   575 ---PPP-------------------------------------------------MPG------- 580

  Fly  1894 GLAKSKSKGEISRSSSVDQDVKKSEPKKSENELHWEELVRNMTRPLNLCDLDFTDLRDDDEKDVL 1958
                                                     |.||
  Fly   581 -----------------------------------------MMRP-------------------- 584

  Fly  1959 APRSLGAGIPPPPPPLGGAIAPPPMMPPSLAPPPMYGYGGSLTNSVNSLNGSINGELVNGNNTIK 2023
                 |.|.||||..:|..:   |::|..|.|...:    .:.|.:...|.          ..|.
  Fly   585 -----GGGPPPPPMMMGPMV---PVLPHGLKPKKKW----DVKNPMKRANW----------KAIV 627

  Fly  2024 KNKKTVKLFWKEVREDMIPQVVGKTIWDELPDANVDTQKLEHLFESR-----AKDLMTKKQQELN 2083
            ..|.:.|.||.:.:||.:.|       |:.      ..:|...|.|:     .||.:.|......
  Fly   628 PAKMSDKAFWVKCQEDKLAQ-------DDF------LAELAVKFSSKPVKKEQKDAVDKPTTLTK 679

  Fly  2084 KSKEIIVLDHKRSNAINIAI-----TKLPPPRAIKTAILKMDATVVTREGIDKLLNMLPTDEERG 2143
            |:.::.|||.|  .|.|:||     .|......||..:|:.|..:::...:.:|:..||..|...
  Fly   680 KNVDLRVLDSK--TAQNLAIMLGGSLKHLSYEQIKICLLRCDTDILSSNILQQLIQYLPPPEHLK 742

  Fly  2144 KIQEAQLSNPELPLGSAEQFLLTLASISELEARLKLWAFRLDFDNSEKEIAEPLMDLKQGIEILR 2208
            ::||.:.....||  ..|||..|:..|..|..||....|:|.:.:..::|...::......|.:|
  Fly   743 RLQEIKAKGEPLP--PIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIR 805

  Fly  2209 QNRTFRSILSTLLSVGIFLNGAPVK----GFQIEYLAKVPEVKDTVHKHSLLHHLCHMVMESSSD 2269
            .::.|..||..:|.:|.::|.....    ||:|.||.|:...||..:|.:|||:|..:|.:...|
  Fly   806 NSKKFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPD 870

  Fly  2270 TSDLYSEIGPITRASKADFTDLAHNLNQLEAECKACWDRLKLIAKHDC-PPPLKQKLVDFLADCA 2333
            ..:.|.::..:.:||:.:...:...:.|:.:..|.....|:......| .....:.:..|..:|.
  Fly   871 ALNFYDDLSHVNKASRVNMDAIQKAMRQMNSAVKNLETDLQNNKVPQCDDDKFSEVMGKFAEECR 935

  Fly  2334 ERIIILQIVHRRVMNRYRKFLLWLGMPQHSVAESRPNEFCRTLSEFALEYRTTRE---------- 2388
            :::.:|..:..::...|:....:....        |:::  |:.||..:.:|.::
  Fly   936 QQVDVLGKMQLQMEKLYKDLSEYYAFD--------PSKY--TMEEFFADIKTFKDAFQAAHNDNV 990

  Fly  2389 RVQQQLEKK----------ANHRERNKTRGKLIIDMAKFKTKDDVADDELKKLLDTSSADQADGT 2443
            ||:::||||          |..::..:.|.|.::||...:|::.|.|..|:.|...|:..|.:..
  Fly   991 RVREELEKKRRLQEAREQSAREQQERQQRKKAVVDMDAPQTQEGVMDSLLEALQTGSAFGQRNRQ 1055

  Fly  2444 LTWRRRRAEQLRSPITR-QSEEQFTDGD--------DEILES 2476
            ...:|....:.|:.::| :|..:.|:|.        :|:|.|
  Fly  1056 ARRQRPAGAERRAQLSRSRSRTRVTNGQLMTREMILNEVLGS 1097

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fhos	NP_001163387.2	FH2	2020..2384	CDD:280362	86/378 (23%)
		CSRNP_N	2357..>2451	CDD:292638	24/113 (21%)
dia	NP_001246113.1	Drf_GBD	66..248	CDD:283920	39/216 (18%)
		Drf_FH3	253..453	CDD:283917	52/303 (17%)
		FH2	608..983	CDD:280362	90/415 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1924
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810