DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fhos and Diaph1

DIOPT Version :9

Sequence 1:	NP_001163387.2	Gene:	Fhos / 39004	FlyBaseID:	FBgn0266084	Length:	2528	Species:	Drosophila melanogaster
Sequence 2:	NP_001100863.3	Gene:	Diaph1 / 307483	RGDID:	1310707	Length:	1266	Species:	Rattus norvegicus

Alignment Length:	1532	Identity:	317/1532 - (20%)
Similarity:	512/1532 - (33%)	Gaps:	480/1532 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1106 SRHQNIDELLGGACRPLSPLFYGNSNPAESELTPLAGKNMFLLEEVTPDQVRIHDSTAQLPVIQR 1170
            |.|:|            |...||:...|:|            |::::.|||        |.:.::
  Rat    66 SAHRN------------SSASYGDDPTAQS------------LQDISDDQV--------LVLFEQ 98

  Fly  1171 MQRDVEWLDNGSNFYEPPEQRQHQPPRRIDDAAIQ---------------VYKDGDYGAYL---D 1217
            |..|:       |..|     :.|.|.|..|..|:               ..|:....|.:   :
  Rat    99 MLVDM-------NLNE-----EKQQPLREKDIVIKREMVSQYLHTSKAGMNQKESSRSAMMYIQE 151

  Fly  1218 LESSLAEQ--AEEIEGVNVSRKNSLVVRTQLNVRVQAIIEKLLSAQGSDLRRALFSLKQVFQEDK 1280
            |.|.|.:.  ...:|.:.||..|:.|...|           ...|:|  |...|..||::..|.:
  Rat   152 LRSGLRDMHLLSCLESLRVSLNNNPVSWVQ-----------TFGAEG--LASLLDILKRLHDEKE 203

  Fly  1281 DLVHAFVALGGLNCLVRVGNCADQNYQNYILRALGQVMLYVDGMNGVMKHEPTMQWLYSLIASNY 1345
            :               ..||...:| |:.|:|.|...|                         |.
  Rat   204 E---------------TSGNYDSRN-QHEIIRCLKAFM-------------------------NN 227

  Fly  1346 RSVVKTALKLLLVFVEYAESNCYVLVSAIHAVDASQGTLPWSNIMRLLKDYDNADAELVIYATSL 1410
            :..:||.|                        :..:|      |:.|::..|.|...::|.|..|
  Rat   228 KFGIKTML------------------------ETEEG------ILLLVRAMDPAVPNMMIDAAKL 262

  Fly  1411 INKTLAGLNDQDSFYDE--SDLLEQQGMETVIQRYMS-----KPGTDLDL-LDQLQLYEAVLKFE 1467
            :: .|..|...:...:.  ..:.|:..||.| :|:..     |.||.:.| :..|||..|::
  Rat   263 LS-ALCILPQPEDMNERVLEAMTERAEMEEV-ERFQPLLDGLKSGTSIALKVGCLQLINALI--- 322

  Fly  1468 DGESDGQRLPQNSMRKTQRYRPGANTTERRKSRRHSTDNSPASLTKVLPTTVLRMTPTQATVDED 1532
               :..:.|......:::..|.|.:.. .::.|....|:....|...                 |
  Rat   323 ---TPAEELDFRVHIRSELMRLGLHQV-LQELREIDNDDMRVQLNVF-----------------D 366

  Fly  1533 SSGSTNSTEFSGGLFNEKKPRDGAGVTPGLRRRRERAERHKSFLKEQQEAAANGIFAALEQ---- 1593
            ..|..:..:..|.|.:.:...|..|            |..:..|...:::.|...|.::.|
  Rat   367 EQGDEDFFDLKGRLDDIRMEMDDFG------------EVFQIILNTVKDSKAEPHFLSILQHLLL 419

  Fly  1594 ---------------REGLGQIVTAIPATIQTGDSPPQSLQH-EVPPCNNISGITN--ISNNNVS 1640
                           .|.:.|||..     :.|..|....:| ::    :|.|:.:  |....|.
  Rat   420 VRNDYEARPQYYKLIEECVSQIVLH-----KNGTDPDFKCRHLQI----DIEGLVDQMIDKTKVE 475

  Fly  1641 NLSCNDTPNNSLLVMSPSKQL---LTGSHSISI----INNSFDKASNNNQSEFLTKKNLFRERNS 1698
            ......|        ...|:|   ||..|.:.:    :.|.|::...:.|.|   |..|..|:..
  Rat   476 KSEAKAT--------ELEKKLDSELTARHELQVEMKKMENDFEQKLQDLQGE---KDALDSEKQQ 529

  Fly  1699 TVINGIMKNIQQTDSAYKKYENEANRLNNYYSQSPKHQIHQPIQPTPEVLLSPKKTLNASGFDFT 1763
                 |....|..::...|...|..:|:.....:.|.     :.....|.::|..:.:|:.....
  Rat   530 -----ITTQKQDLEAEVSKLTGEVAKLSKELEDAKKE-----MASLSAVAVAPSVSSSAAVPQAP 584

  Fly  1764 PAPLSSTPVKCDVPPEPEPLSPVKKPAAAPPPPPPPP-------PPPPPPPGWWHAPIYNSPQAR 1821
            |.|..|..|   :||.|.| .|:  |..|.|||||||       |||||.||  .|.|.:|||..
  Rat   585 PLPGDSGTV---IPPPPPP-PPL--PGGAVPPPPPPPLPAGTGIPPPPPLPG--GACISSSPQLF 641

  Fly  1822 TLTSTNP--------ELLPHPVDPSDMESEDQQLLLQLKRDHTVKDLTQKLSNLPMSPTQDSANR 1878
            ..|:..|        .:.|.|..|.                         .:.:|..|....|..
  Rat   642 GSTAIPPPPPLPGATAIPPPPPLPG-------------------------ATAIPPPPPLPGATA 681

  Fly  1879 -----ALVGDMSGLISKAKEGLAKSKSKGEISRSSSVDQDVKKSEPKKSENELHWEELVRNMTRP 1938
                 .|.|                 :.|.......:...|....|
  Rat   682 IPPPPPLPG-----------------ATGVPPPPPPLPGSVGVPPP------------------- 710

  Fly  1939 LNLCDLDFTDLRDDDEKDVLAPRSLGAGIPPPPPPLGGAIA-PPPMMPPSLA--PPPMYGYGGSL 2000
                                .|...|.|:||||||..||.. |||  ||.:.  |||.:|:|...
  Rat   711 --------------------PPLPGGPGLPPPPPPFPGAPGIPPP--PPGMGVPPPPPFGFGIPA 753

  Fly  2001 TNSVNSLNGSINGELVNGNNTIKKNKKTVKL-----------------FWKEVREDMIPQVVGKT 2048
            .           ..|..|....|..|..|:|                 ||.:|:||..
  Rat   754 A-----------PVLPFGLTPKKVYKPEVQLRRPNWSKFVAEDLSQDCFWTKVKEDRF------- 800

  Fly  2049 IWDELPDANVDTQKLEHLFESRAKDLMTKKQQE---------LNKSKEIIVLDHKRSNAINIAIT 2104
                  :.|....||...|.::.|....||.||         ..|.||:.|||.|.:..::|.:.
  Rat   801 ------ENNELFAKLTLAFSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKVLDSKTAQNLSIFLG 859

  Fly  2105 KLPPP-RAIKTAILKMDATVVTREGIDKLLNMLPTDEERGKIQEAQLSNPELPLGSAEQFLLTLA 2168
            ....| :.||..||:::..|:|...|..|:..:|..|:...:.|  |......|..:|||.:.:.
  Rat   860 SFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQLKMLSE--LKEEYDDLAESEQFGVVMG 922

  Fly  2169 SISELEARLKLWAFRLDFDNSEKEIAEPLMDLKQGIEILRQNRTFRSILSTLLSVGIFLN----G 2229
            ::..|..||....|:|.|....:.|...::.:....|.||::..|.|:|...|.||.::|    .
  Rat   923 TVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSENFSSLLELTLLVGNYMNAGSRN 987

  Fly  2230 APVKGFQIEYLAKVPEVKDTVHKHSLLHHLCHMVMESSSDTSDLYSEIGPITRASKADFTDLAHN 2294
            |...||.|.:|.|:.:.|....|.:|||.|..:......|......|:..:.:||:....:|..|
  Rat   988 AGAFGFNISFLCKLRDTKSADQKMTLLHFLAELCETDHPDVLKFPDELAHVEKASRVSAENLQKN 1052

  Fly  2295 LNQLE---AECKACWDRLKLIAKHDCPPPLKQKLVDFLADCAERIIILQIVHRRVMNRYRKFLLW 2356
            |:|::   |:.:.  |.....|..|......:|:..|:.|..|:...|:::|..:...|::
  Rat  1053 LDQMKKQIADVER--DVQNFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKE---- 1111

  Fly  2357 LGMPQHSVAESRPNEFCRTLSEFALEYRTTRERVQQQLEKKANHRERNK--TRGKLIIDMAKFKT 2419
            ||  .:.|.:  |.:.  ::.||.::....|....|.:::....||..:  .|.||    ||.|.
  Rat  1112 LG--DYFVFD--PKKL--SVEEFFMDLHNFRNMFLQAVKENQKRRETEEKMRRAKL----AKEKA 1166

  Fly  2420 KDDVADDELKK--LLDTSSADQADGTL-----------TWRRRRAEQ-------------LRSPI 2458
            :.:..:.:.|:  |:|.::.....|.:           .:||:|..:             |.|.:
  Rat  1167 EKERLEKQQKREQLIDMNAEGDETGVMDSLLEALQSGAAFRRKRGPRQVNRKAGCAVTSLLASEL 1231

  Fly  2459 TRQSEEQFTDGDDEILESLVKTATKAPGTRTTPRERK 2495
            |:         ||.:..|..|...|:.|..|...|.|
  Rat  1232 TK---------DDAVAASSAKVPKKSEGVTTILEEAK 1259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fhos	NP_001163387.2	FH2	2020..2384	CDD:280362	97/397 (24%)
Fhos	NP_001163387.2	CSRNP_N	2357..>2451	CDD:292638	22/108 (20%)
Diaph1	NP_001100863.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..83		7/28 (25%)
Diaph1	NP_001100863.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	503..531		7/35 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1924
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810