DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fhos and Fhod1

DIOPT Version :9

Sequence 1:	NP_001163387.2	Gene:	Fhos / 39004	FlyBaseID:	FBgn0266084	Length:	2528	Species:	Drosophila melanogaster
Sequence 2:	XP_008770705.1	Gene:	Fhod1 / 291964	RGDID:	1589776	Length:	1206	Species:	Rattus norvegicus

Alignment Length:	1428	Identity:	519/1428 - (36%)
Similarity:	704/1428 - (49%)	Gaps:	361/1428 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1162 TAQLPVIQRMQRDVEWLDNGSNFYEPPEQRQHQPPRRIDDAAIQVYKDGDYGAYLDLESSLAEQA 1226
            :||:|.:.|:.        |:             |.:::|.|:||   ...|.|||.|.||.||.
  Rat    52 SAQIPALHRLL--------GA-------------PLKLEDCALQV---SPSGYYLDPELSLEEQR 92

  Fly  1227 EEIEG----VNVSRKNSLVVRTQLNVRVQAIIEKLLSAQGSDLRRALFSLKQVFQEDKDLVHAFV 1287
            |.:||    ::..||.:|::||||:|||.||:|||..:.|.:|||:||||||:||||||||..||
  Rat    93 EMLEGFYEEISKGRKPTLILRTQLSVRVNAILEKLYGSSGPELRRSLFSLKQIFQEDKDLVPEFV 157

  Fly  1288 ALGGLNCLVRVGNCADQNYQNYILRALGQVMLYVDGMNGVMKHEPTMQWLYSLIASNYRSVVKTA 1352
            ...||:||:|||..||.|||:||||||||:||:||||.||:.|..|:||||:|.||..|.|||||
  Rat   158 HSEGLSCLIRVGAAADHNYQSYILRALGQLMLFVDGMLGVVAHSETVQWLYTLCASLSRLVVKTA 222

  Fly  1353 LKLLLVFVEYAESNCYVLVSAIHAVDASQGTLPWSNIMRLLKDYDNADAELVIYATSLINKTLAG 1417
            ||||||||||:|:|..:.:.|::||.::.|||||:|::.:|::.:..|.||::|..:|||||||.
  Rat   223 LKLLLVFVEYSENNAPLFIQAVNAVASNTGTLPWANLVSILEEKNGVDPELLVYTVTLINKTLAA 287

  Fly  1418 LNDQDSFYDESDLLEQQGMETVIQRYMSKPGTDLDLLDQLQLYEAVLKFEDGESDGQRLPQNSMR 1482
            |.|||||||.:|..||||||.::||.:...|||:||..||.|||:.|:.|||:.:.......:..
  Rat   288 LPDQDSFYDVTDAFEQQGMEALVQRLLGTAGTDVDLRTQLTLYESALRLEDGDMEEAAAAAAAGG 352

  Fly  1483 KTQRYRPGANTTERRKSRRHSTDNSPASLTKVLPTTVLRMTPTQATVDEDSSGSTNSTEFSGGLF 1547
            :.:|.:|  ::.|.::|||......       .|.......||.:.....|:..|:||..:...|
  Rat   353 RRERRKP--SSEEGKRSRRSLEGGG-------CPVRTPEPGPTGSASPVGSASFTDSTSPTSSAF 408

  Fly  1548 NEKKPRDGAGVTPGLRRRRERAERHKSFLKEQQEAAANGIFAALEQREGLGQIVTAIPATIQTGD 1612
            :...|..|.               |.|                          |...| ||..|.
  Rat   409 SPTGPASGL---------------HTS--------------------------VNLFP-TISVGP 431

  Fly  1613 SPPQSLQHEVPPCNNISGITNISNNNVSNLSCNDTPNNSLLVMSPSKQLLTGSHSISIINNSFDK 1677
            |...|.:..|...:..:.|            |:.   .||    |..|.|||...:
  Rat   432 SVDTSCERSVYKLHQTAPI------------CSP---ESL----PVPQSLTGQARL--------- 468

  Fly  1678 ASNNNQSEFLTKKNLFRERNSTVINGIMKNIQQTDSAYKKYENEANRLNNYYSQSPKHQIHQPIQ 1742
                 ::.||                  :|:...:
  Rat   469 -----EARFL------------------ENVAAAE------------------------------ 480

  Fly  1743 PTPEVLLSPKKTLNASGFDFTPAPLSSTPVKCDVPPEPEPLSPVKKPAAAPPPPPPPPPPPPPPP 1807
                   :.|:...|.|...|.|  .:|..:.|.......|....:||:||.||..|..|
  Rat   481 -------TEKQAALAQGRAETLA--GATVDETDESSGTRELWDSSEPASAPRPPQSPVSP----- 531

  Fly  1808 GWWHAPIYNSPQARTLTSTNPELLPHPVDPSDMESEDQQLLLQLKRDHTVKDLTQKLSNLPMSPT 1872
                          .:..|...|.|.|.:|..                            |.||
  Rat   532 --------------IVLRTQRSLEPEPKEPVS----------------------------PRSP- 553

  Fly  1873 QDSANRALVGDMSGLISKAKEGLAKSKSKGEISRSSSVDQDVKKSEPKKSENELHWEELVRNMTR 1937
                                                       |:||.        :||..::.:
  Rat   554 -------------------------------------------KTEPV--------QELPTHVPK 567

  Fly  1938 PLNLC--DLDFTDLRDDDEKDV----------------LAPRSLGAGIPPPPPPLGGAIAPPPMM 1984
               ||  ||||:||.:|:::|.                |.|.|...|.||||||      |||::
  Rat   568 ---LCIGDLDFSDLGEDEDQDTLNVESVEAGKASLVLSLPPSSFSGGPPPPPPP------PPPII 623

  Fly  1985 -----PPSLAPPPMYG-------YGGSLTNSVNSLNGSINGELVNGNNTIKKNKKTVKLFWKEVR 2037
                 ||...|||:.|       ......:|  :|:|..:          ...:|||||||:|::
  Rat   624 VSCPPPPPPPPPPIMGSCLPPPPLAAPFPHS--ALDGPRH----------PTKRKTVKLFWRELK 676

  Fly  2038 EDMIPQVVGK------TIWDELPDANVDTQKLEHLFESRAKDLMTKKQQELNKSKEIIVLDHKRS 2096
            ....|.....      |:|..|...:|||.:|||||||||||::..|:....:....||||.|||
  Rat   677 PTGSPGCSRSRFGPCPTLWASLEPVSVDTARLEHLFESRAKDVLPTKKAGEGRRTMTIVLDPKRS 741

  Fly  2097 NAINIAITKLPPPRAIKTAILKMDATVVTREGIDKLLNMLPTDEERGKIQEAQLSNPELPLGSAE 2161
            |||||.:|.|||...||.|:|..|...|:::||:|||.|:||:|||.||:||||:||::|||.||
  Rat   742 NAINIGLTTLPPVHVIKAALLNFDEFAVSKDGIEKLLTMMPTEEERQKIEEAQLANPDVPLGPAE 806

  Fly  2162 QFLLTLASISELEARLKLWAFRLDFDNSEKEIAEPLMDLKQGIEILRQNRTFRSILSTLLSVGIF 2226
            .||:|||||..|.|||:||||:||:::.|:||||||.|||.|:|.|..|.|||.||:|||:||.|
  Rat   807 NFLMTLASIGGLAARLQLWAFKLDYESMEREIAEPLFDLKVGMEQLVHNATFRCILATLLAVGNF 871

  Fly  2227 LNGAPVKGFQIEYLAKVPEVKDTVHKHSLLHHLCHMVMESSSDTSDLYSEIGPITRASKADFTDL 2291
            |||:...||::.||.||.||||||.:.|||:|||.:|:::..|:|||||||..:||.:|.||..|
  Rat   872 LNGSQSSGFELSYLEKVSEVKDTVRRQSLLYHLCSLVLQTRPDSSDLYSEIPALTRCAKVDFEQL 936

  Fly  2292 AHNLNQLEAECKACWDRLKLIAKHDCPPPLKQKLVDFLADCAERIIILQIVHRRVMNRYRKFLLW 2356
            ..||.|||...:|..|.|:.:|||:..|.|:.:|..|||.|..|:.:|::|||||.||:..|||:
  Rat   937 TENLGQLECRSQAAEDSLRSLAKHELSPALRARLTHFLAQCTRRVAMLRVVHRRVCNRFHAFLLY 1001

  Fly  2357 LGMPQHSVAESRPNEFCRTLSEFALEYRTTRERVQQQLEKKANHRERNKTRGKLIIDMAKFK--- 2418
            ||....:..|.|..:||.||.||||||||.||||.||.:|:|.:||||||||::|.:..||.
  Rat  1002 LGYTAQAAREVRIMQFCHTLREFALEYRTCRERVLQQQQKRATYRERNKTRGRMITETEKFSGVA 1066

  Fly  2419 -----------------TKDDVADDELKKLLDTSSADQADGTLTWRRRRAEQLRSPITRQSEEQF 2466
                             .:.|..:....|.|.||..:  |.|.:.|.|...|..||:|..:...|
  Rat  1067 GEVPSNLSVPVAVGSGPGRGDADNHASMKSLLTSRPE--DATHSRRSRGMVQSSSPVTHTTVGPF 1129

  Fly  2467 T-------------DGDDEILESLVKTATKAPGTRTTPRERKRTRHADRKSLRRTLKNGLTEE 2516
            |             |..|||::.||::.||:.......|||||:| .:|||||||||:||.::
  Rat  1130 TASPEETAASGLPSDTSDEIMDLLVQSVTKSSPRALAARERKRSR-GNRKSLRRTLKSGLGDD 1191

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fhos	NP_001163387.2	FH2	2020..2384	CDD:280362	194/369 (53%)
Fhos	NP_001163387.2	CSRNP_N	2357..>2451	CDD:292638	44/113 (39%)
Fhod1	XP_008770705.1	FH2	657..1029	CDD:280362	195/381 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	112	1.000	Domainoid score	I6067
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003497
OrthoInspector	1	1.000	-	-		otm46195
orthoMCL	1	0.900	-	-		OOG6_104165
Panther	1	1.100	-	-	LDO	PTHR45920
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2390
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.910