Protein Alignment Fhos and FHOD1

DIOPT Version :9

• Sequence 1: NP_001163387.2
• Gene: Fhos / 39004
• FlyBaseID: FBgn0266084
• Length: 2528
• Species: Drosophila melanogaster
• Sequence 2: NP_001305131.1
• Gene: FHOD1 / 29109
• HGNCID: 17905
• Length: 1190
• Species: Homo sapiens
• Alignment Length: 1417
• Identity: 521/1417 - (36%)
• Similarity: 696/1417 - (49%)
• Gaps: 357/1417 - (25%)

  Fly  1163 AQLPVIQRMQRDVEWLDNGSNFYEPPEQRQHQPPRRIDDAAIQVYKDGDYGAYLDLESSLAEQAE 1227
            ||:|.:.|:.        |:             |.:::|.|:||   ...|.|||.|.||.||.|
Human    53 AQIPAVHRLL--------GA-------------PLKLEDCALQV---SPSGYYLDTELSLEEQRE 93

  Fly  1228 EIEG----VNVSRKNSLVVRTQLNVRVQAIIEKLLSAQGSDLRRALFSLKQVFQEDKDLVHAFVA 1288
            .:||    ::..||.:|::||||:|||.||:|||.|:.|.:|||:||||||:||||||||..||.
Human    94 MLEGFYEEISKGRKPTLILRTQLSVRVNAILEKLYSSSGPELRRSLFSLKQIFQEDKDLVPEFVH 158

  Fly  1289 LGGLNCLVRVGNCADQNYQNYILRALGQVMLYVDGMNGVMKHEPTMQWLYSLIASNYRSVVKTAL 1353
            ..||:||:|||..||.|||:||||||||:||:||||.||:.|..|:||||:|.||..|.||||||
Human   159 SEGLSCLIRVGAAADHNYQSYILRALGQLMLFVDGMLGVVAHSDTIQWLYTLCASLSRLVVKTAL 223

  Fly  1354 KLLLVFVEYAESNCYVLVSAIHAVDASQGTLPWSNIMRLLKDYDNADAELVIYATSLINKTLAGL 1418
            |||||||||:|:|..:.:.|:::|.::.|..||:|::.:|::.:.||.||::|..:|||||||.|
Human   224 KLLLVFVEYSENNAPLFIRAVNSVASTTGAPPWANLVSILEEKNGADPELLVYTVTLINKTLAAL 288

  Fly  1419 NDQDSFYDESDLLEQQGMETVIQRYMSKPGTDLDLLDQLQLYEAVLKFEDGESDGQRLPQNSMRK 1483
            .|||||||.:|.|||||||.::||::...|||:||..||.|||..||.|||:.:
Human   289 PDQDSFYDVTDALEQQGMEALVQRHLGTAGTDVDLRTQLVLYENALKLEDGDIE----------- 342

  Fly  1484 TQRYRPGA-NTTERRKSRRHSTDNSPASLTKVLPTTVLRMTPTQATVDEDSSGSTNSTEFSGGLF 1547
               ..||| ...||||         |:|                    |:...|..|.|  ||..
Human   343 ---EAPGAGGRRERRK---------PSS--------------------EEGKRSRRSLE--GGGC 373

  Fly  1548 NEKKPRDGAGVTPGLRRRRERAERHKSFLKEQQEAAANGIFAALEQREGLGQIVTAIPATIQTGD 1612
            ..:.|..|                            ..|..:.:......|..:...||:...|
Human   374 PARAPEPG----------------------------PTGPASPVGPTSSTGPALLTGPASSPVG- 409

  Fly  1613 SPPQSLQHEVPPCNNISGITNISNNNVSNLSCNDTPNNSLLVMSPSKQLLTGSHSISIINNSFDK 1677
             ||..||..|                                                  |.|..
Human   410 -PPSGLQASV--------------------------------------------------NLFPT 423

  Fly  1678 ASNNNQSEFLTKKNLFRERNSTVINGIMKNIQQTDSAYKKYENEANRLNNYYSQSPKHQIHQPIQ 1742
            .|....::..:::::::             :.||.|.:.......       .|||..|.....:
Human   424 ISVAPSADTSSERSIYK-------------LHQTASVWAPESPPV-------PQSPPGQARLEAR 468

  Fly  1743 PTPEVLL--SPKKTLNASGFDFTPAPLSSTPVKCDVPPEPEPL--SPVKKPAAAPPPPPPPPPPP 1803
            ....|..  :.|:...|.|...|.|  .:.|.:....|:...|  ||...|||..|..|.|
Human   469 FLENVAAAETEKQVALAQGRAETLA--GAMPNEAGGHPDARQLWDSPETAPAARTPQSPAP---- 527

  Fly  1804 PPPPGWWHAPIYNSPQARTLTSTNPELLPHPVDPSDMESEDQQLLLQLKRDHTVKDLTQKLSNLP 1868
                             ..|......|.|.|.:|.                            :|
Human   528 -----------------CVLLRAQRSLAPEPKEPL----------------------------IP 547

  Fly  1869 MSPTQDSANRALVGDMSGLISKAKEGLAKSKSKGEISRSSSVDQDVKKSEPKKSENELHWEELVR 1933
            .||                                            |:||       .||...|
Human   548 ASP--------------------------------------------KAEP-------IWELPTR 561

  Fly  1934 NMTRPLNLCDLDFTDLRDDDEKDVLAPRSLGAG--IPPPPPP---LGGAIAPPPMMPP-----SL 1988
              ...|::.||||:||.:|:::|:|...|:.||  ||.|.||   |.|...|||:.||     ..
Human   562 --APRLSIGDLDFSDLGEDEDQDMLNVESVEAGKDIPAPSPPLPLLSGVPPPPPLPPPPPIKGPF 624

  Fly  1989 APPPMYGYGGSLTNSVNSLNGSINGELVNGNNTIKKNKKTVKLFWKEVREDMIPQVVG------- 2046
            .|||.......|.:||..            ::.:...:|||||||:|::      :.|
Human   625 PPPPPLPLAAPLPHSVPD------------SSALPTKRKTVKLFWRELK------LAGGHGVSAS 671

  Fly  2047 -----KTIWDELPDANVDTQKLEHLFESRAKDLMTKKQQELNKSKEIIVLDHKRSNAINIAITKL 2106
                 .|:|..|...:|||.:||||||||||:::..|:....:.....|||.||||||||.:|.|
Human   672 RFGPCATLWASLDPVSVDTARLEHLFESRAKEVLPSKKAGEGRRTMTTVLDPKRSNAINIGLTTL 736

  Fly  2107 PPPRAIKTAILKMDATVVTREGIDKLLNMLPTDEERGKIQEAQLSNPELPLGSAEQFLLTLASIS 2171
            ||...||.|:|..|...|:::||:|||.|:||:|||.||:||||:||::|||.||.||:|||||.
Human   737 PPVHVIKAALLNFDEFAVSKDGIEKLLTMMPTEEERQKIEEAQLANPDIPLGPAENFLMTLASIG 801

  Fly  2172 ELEARLKLWAFRLDFDNSEKEIAEPLMDLKQGIEILRQNRTFRSILSTLLSVGIFLNGAPVKGFQ 2236
            .|.|||:||||:||:|:.|:||||||.|||.|:|.|.||.|||.||:|||:||.||||:...||:
Human   802 GLAARLQLWAFKLDYDSMEREIAEPLFDLKVGMEQLVQNATFRCILATLLAVGNFLNGSQSSGFE 866

  Fly  2237 IEYLAKVPEVKDTVHKHSLLHHLCHMVMESSSDTSDLYSEIGPITRASKADFTDLAHNLNQLEAE 2301
            :.||.||.||||||.:.|||||||.:|:::..::|||||||..:||.:|.||..|..||.|||..
Human   867 LSYLEKVSEVKDTVRRQSLLHHLCSLVLQTRPESSDLYSEIPALTRCAKVDFEQLTENLGQLERR 931

  Fly  2302 CKACWDRLKLIAKHDCPPPLKQKLVDFLADCAERIIILQIVHRRVMNRYRKFLLWLGMPQHSVAE 2366
            .:|..:.|:.:|||:..|.|:.:|..||..||.|:.:|:||||||.||:..|||:||....:..|
Human   932 SRAAEESLRSLAKHELAPALRARLTHFLDQCARRVAMLRIVHRRVCNRFHAFLLYLGYTPQAARE 996

  Fly  2367 SRPNEFCRTLSEFALEYRTTRERVQQQLEKKANHRERNKTRGKLIIDMAKFK------------- 2418
            .|..:||.||.||||||||.||||.||.:|:|.:||||||||::|.:..||.
Human   997 VRIMQFCHTLREFALEYRTCRERVLQQQQKQATYRERNKTRGRMITETEKFSGVAGEAPSNPSVP 1061

  Fly  2419 -------TKDDVADDELKKLLDTSSADQADGTLTWRRRRAEQLRSPI-------TRQSEEQ---- 2465
                   .:.|.......|.|.||..:  |.|...|.|...|..|||       |...||.
Human  1062 VAVSSGPGRGDADSHASMKSLLTSRPE--DTTHNRRSRGMVQSSSPIMPTVGPSTASPEEPPGSS 1124

  Fly  2466 -FTDGDDEILESLVKTATKAPGTRTTPRERKRTRHADRKSLRRTLKNGLTEE 2516
             .:|..|||::.||::.||:.......|||||:| .:|||||||||:||.::
Human  1125 LPSDTSDEIMDLLVQSVTKSSPRALAARERKRSR-GNRKSLRRTLKSGLGDD 1175

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fhos	NP_001163387.2	FH2	2020..2384	CDD:280362	194/375 (52%)
		CSRNP_N	2357..>2451	CDD:292638	44/113 (39%)
FHOD1	NP_001305131.1	Jun	<385..467	CDD:281890	19/153 (12%)
		FH2	642..1014	CDD:280362	194/389 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	110	1.000	Domainoid score	I6306
eggNOG	1	0.900	-	-		E1_KOG1924
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40860
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003497
OrthoInspector	1	1.000	-	-		otm42051
orthoMCL	1	0.900	-	-		OOG6_104165
Panther	1	1.100	-	-	LDO	PTHR45920
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3293
SonicParanoid	1	1.000	-	-		X2390
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.840