DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fhos and DIAPH1

DIOPT Version :9

Sequence 1:	NP_001163387.2	Gene:	Fhos / 39004	FlyBaseID:	FBgn0266084	Length:	2528	Species:	Drosophila melanogaster
Sequence 2:	XP_024310152.1	Gene:	DIAPH1 / 1729	HGNCID:	2876	Length:	1313	Species:	Homo sapiens

Alignment Length:	1398	Identity:	289/1398 - (20%)
Similarity:	468/1398 - (33%)	Gaps:	441/1398 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1327 VMKHEPTMQWLYSLIASNYRSVVKTALKLLLVFVEYAESNC--YVLVSAIHAVDASQGTLPWS-- 1387
            ::|.|...|:||:..|...:   |.:.|..:::::...|..  ..|:|.:.::..|....|.|
Human   119 IIKREMVSQYLYTSKAGMSQ---KESSKSAMMYIQELRSGLRDMPLLSCLESLRVSLNNNPVSWV 180

  Fly  1388 ------------NIMRLLKD--------YDNADAELVIYATSLINKTLAGLNDQDSFYDESDLLE 1432
                        :|::.|.|        ||:.:...:|...........|:         ..:||
Human   181 QTFGAEGLASLLDILKRLHDEKEETAGSYDSRNKHEIIRCLKAFMNNKFGI---------KTMLE 236

  Fly  1433 QQGMETVIQRYMSKPGTDLDLLDQLQLYEAVLKFEDGESDGQRL-----PQNSMRKTQRYRP--- 1489
            .:....::.|.|. |.....::|..:|..|:......|...:|:     .:..|.:.:|::|
Human   237 TEEGILLLVRAMD-PAVPNMMIDAAKLLSALCILPQPEDMNERVLEAMTERAEMDEVERFQPLLD 300

  Fly  1490 --GANTT------------------ERRKSRRHSTDNSPASLTKVLPTTVLRMTPTQATVD---- 1530
              .:.||                  |....|.|            :.:.::|:...|...|
Human   301 GLKSGTTIALKVGCLQLINALITPAEELDFRVH------------IRSELMRLGLHQVLQDLREI 353

  Fly  1531 -----------EDSSGSTNSTEFSGGL---------FNE------KKPRDGAGVTPGLRRRRERA 1569
                       .|..|..:|.:..|.|         |||      ...:|            .:|
Human   354 ENEDMRVQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEVFQILLNTVKD------------SKA 406

  Fly  1570 E-------RHKSFLKEQQEAAANGIFAALEQREGLGQIVTAIPATIQTGDSPPQSLQH-EVPPCN 1626
            |       :|...::...||... .:..:|  |.:.|||..     :.|..|....:| ::
Human   407 EPHFLSILQHLLLVRNDYEARPQ-YYKLIE--ECISQIVLH-----KNGADPDFKCRHLQI---- 459

  Fly  1627 NISGITN--ISNNNVSNLSCNDTPNNSLLVMSPSKQL---LTGSHSISI----INNSFDKASNNN 1682
            .|.|:.:  |....|.        .:........|:|   ||..|.:.:    :.:.|::...:.
Human   460 EIEGLIDQMIDKTKVE--------KSEAKAAELEKKLDSELTARHELQVEMKKMESDFEQKLQDL 516

  Fly  1683 QSEFLTKKNLFRERNSTVINGIMKNIQQTDSAYKKYENEANRLNNYYSQSPKHQIHQPIQPTPEV 1747
            |.|   |..|..|:            ||..:..:..|.|.::|....::..|.
Human   517 QGE---KDALHSEK------------QQIATEKQDLEAEVSQLTGEVAKLTKE------------ 554

  Fly  1748 LLSPKK---TLNASGFDFTPAPLSSTPVKCDVPPEPE---------PLSPVKKPAAAPPPPPPPP 1800
            |...||   :|:|:.....|    |.|.:..|||.|.         |..|....:..||||||||
Human   555 LEDAKKEMASLSAAAITVPP----SVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPP 615

  Fly  1801 PPPPPPPGWWHAPIYNSPQARTLTSTNPELLPHPVDPSDMESEDQQLLLQLKRDHTVKDLTQKLS 1865
            |||||.||  ...|.:.|.....|:.:|   |.|                |..|.|:
Human   616 PPPPPLPG--GVCISSPPSLPGGTAISP---PPP----------------LSGDATI-------- 651

  Fly  1866 NLPMSPTQDSANRALVGDMSGLISKAKEGLAKSKSKGEISRSSSVDQDVKKSEPKKSENELHWEE 1930
              |..|                  ...||:.       |...||:........|.    .|....
Human   652 --PPPP------------------PLPEGVG-------IPSPSSLPGGTAIPPPP----PLPGSA 685

  Fly  1931 LVRNMTRPLNLCDLDFTDLRDDDEKDVLAPRSLG-----------AGIPPPPPPL--GGAIAPPP 1982
            .:.....||                    |.|.|           ||:|||||||  |..|.|||
Human   686 RIPPPPPPL--------------------PGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPP 730

  Fly  1983 -------MMPP----SLAPPPMYGYGGSLTNSVNSLNGSINGELVNGNNTIKKNKKTVKL----- 2031
                   :.||    .:.|||.:|:|....           ..|..|....|..|..|:|
Human   731 PFPGGPGIPPPPPGMGMPPPPPFGFGVPAA-----------PVLPFGLTPKKLYKPEVQLRRPNW 784

  Fly  2032 ------------FWKEVREDMIPQVVGKTIWDELPDANVDTQKLEHLFESRAKDLMTKKQQE--- 2081
                        ||.:|:||..             :.|....||...|.::.|....||.||
Human   785 SKLVAEDLSQDCFWTKVKEDRF-------------ENNELFAKLTLTFSAQTKTSKAKKDQEGGE 836

  Fly  2082 ------LNKSKEIIVLDHKRSNAINIAITKLPPP-RAIKTAILKMDATVVTREGIDKLLNMLPTD 2139
                  ..|.||:.|||.|.:..::|.:.....| :.||..||:::..|:|...|..|:..:|..
Human   837 EKKSVQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEP 901

  Fly  2140 EERGKIQEAQLSNPELPLGSAEQFLLTLASISELEARLKLWAFRLDFDNSEKEIAEPLMDLKQGI 2204
            |:...:.|  |.:....|..:|||.:.:.::..|..||....|:|.|....:.|...::.:....
Human   902 EQLKMLSE--LKDEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAAC 964

  Fly  2205 EILRQNRTFRSILSTLLSVGIFLN----GAPVKGFQIEYLAKVPEVKDTVHKHSLLHHLCHMVME 2265
            |.||::.:|.::|...|.||.::|    .|...||.|.:|.|:.:.|.|..|.:|||.|..:...
Human   965 EELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQKMTLLHFLAELCEN 1029

  Fly  2266 SSSDTSDLYSEIGPITRASKADFTDLAHNLNQLEAECKAC-WDRLKLIAKHDCPPPLKQKLVDFL 2329
            ...|......|:..:.:||:....:|..||:|::.:.... .|.....|..|......:|:..|:
Human  1030 DYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSFV 1094

  Fly  2330 ADCAERIIILQIVHRRVMNRYRKF-LLWLGMPQHSVAESRPNEFCRTLSEF------ALEYRTTR 2387
            .|..|:...|:::|..:...|::. ..:|..|:....|    ||...|..|      :..|..|.
Human  1095 KDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVE----EFFMDLHNFRNMFLVSKGYLLTE 1155

  Fly  2388 ERV----------------------------QQQLEKKANHRERNK--TRGKLIIDMAKFKTKDD 2422
            ..|                            ||.:::....||..:  .|.||        .|:.
Human  1156 SFVGISHFPLGSCWLVVGIQCPCVPSSSSLPQQAVKENQKRRETEEKMRRAKL--------AKEK 1212

  Fly  2423 VADDELKKLLDTSSADQADGTLTWRRRRAEQLRSPITRQSEEQFTDGDDEILESLVKTATKAPGT 2487
            ...:.|:|                 :::.|||   |...:|...|...|.:||:|...|..
Human  1213 AEKERLEK-----------------QQKREQL---IDMNAEGDETGVMDSLLEALQSGAAF---- 1253

  Fly  2488 RTTPRERKRTRHADRK---SLRRTLKNGLTEEE 2517
                |.::..|.|:||   ::...|.:.||:::
Human  1254 ----RRKRGPRQANRKAGCAVTSLLASELTKDD 1282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fhos	NP_001163387.2	FH2	2020..2384	CDD:280362	97/402 (24%)
Fhos	NP_001163387.2	CSRNP_N	2357..>2451	CDD:292638	20/129 (16%)
DIAPH1	XP_024310152.1	Drf_GBD	84..268	CDD:310750	29/161 (18%)
		Drf_FH3	274..464	CDD:310747	35/225 (16%)
		SMC_N	<429..>570	CDD:330553	34/187 (18%)
		Drf_FH1	598..>700	CDD:283903	38/181 (21%)
		FH2	769..1145	CDD:280362	97/394 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910