Protein Alignment Fhos and Diaph1

DIOPT Version :9

• Sequence 1: NP_001163387.2
• Gene: Fhos / 39004
• FlyBaseID: FBgn0266084
• Length: 2528
• Species: Drosophila melanogaster
• Sequence 2: NP_001292909.1
• Gene: Diaph1 / 13367
• MGIID: 1194490
• Length: 1264
• Species: Mus musculus
• Alignment Length: 1741
• Identity: 331/1741 - (19%)
• Similarity: 548/1741 - (31%)
• Gaps: 628/1741 - (36%)

  Fly   897 PSNGSQRSSKSSASKNGSN-----PKSGGANPWWLSGPARKMFNVQRVESGERAWW-----QEEA 951
            ||.|.....:.:..|....     |.:||      .|...|.|.::|:.:.|...:     ::|.
Mouse     3 PSGGGLGPGRGTRDKKKGRSPDELPATGG------DGGKHKKFTLKRLMADELERFTSMRIKKEK 61

  Fly   952 EEPPQEEKESEPPPVKPPTPPPRIIKHWESGERAWWLQDETESNQLPVQASSDDEEQPVLVVINQ 1016
            |:|....:.|.......||                            .|:..|..::.|||:..|
Mouse    62 EKPNSAHRNSSASYGDDPT----------------------------AQSLQDISDEQVLVLFEQ 98

  Fly  1017 QESRDEVDLRLAPPTLESQELSNSFNFDAHSERPPPLGQCASPVR--CPSPYDNIPRSQLQEPPP 1079
            .    .||:.|                  :.|:..||.:....::  ..|.|.:..::.:.:..
Mouse    99 M----LVDMNL------------------NEEKQQPLREKDIVIKREMVSQYLHTSKAGMNQKE- 140

  Fly  1080 PPTTTLTSLQPRFSPQTRRAG----------EKLFISRHQNIDELLGGACRPLSPLFYGNSNPAE 1134
                  :|.......|..|:|          |.|.:|.:.|
Mouse   141 ------SSRSAMMYIQELRSGLRDMHLLSCLESLRVSLNNN------------------------ 175

  Fly  1135 SELTPLAGKNMFLLEEVTPDQVRIHDSTAQLPVIQRMQRDVEWLDNGSNFYEPPEQRQHQPPRRI 1199
                |::....|..|.:          .:.|.:::|:..:.|  :...|:   ..:.||:..|
Mouse   176 ----PVSWVQTFGAEGL----------ASLLDILKRLHDEKE--ETSGNY---DSRNQHEIIR-- 219

  Fly  1200 DDAAIQVYKDGDYGAYLDLESSLAEQAEEIEGVNVSRKNSLVVRTQ----LNVRVQAIIEKLLSA 1260
               .::.:.:..:|....||:.        ||:      .|:||..    .|:.:.|  .|||||
Mouse   220 ---CLKAFMNNKFGIKTMLETE--------EGI------LLLVRAMDPAVPNMMIDA--AKLLSA 265

  Fly  1261 -----QGSDL-RRALFSLKQVFQEDKDLVHAFVAL-----GGLNCLVRVGNCADQNYQNYILRAL 1314
                 |..|: .|.|.::.:  :.:.|.|..|..|     .|.:..::|| |.  ...|.::...
Mouse   266 LCILPQPEDMNERVLEAMTE--RAEMDEVERFQPLLDGLKSGTSIALKVG-CL--QLINALITPA 325

  Fly  1315 GQVMLYVDGMNGVMK---HEPTMQWLYSLIASNYRSVVKTALKL-LLVFVEYAESNCYVLVSAIH 1375
            .::...|...:.:|:   |:         :....|.:....:|: |.||.|..:.:.:.|
Mouse   326 EELDFRVHIRSELMRLGLHQ---------VLQELREIENEDMKVQLCVFDEQGDEDFFDL----- 376

  Fly  1376 AVDASQGTLPWSNIMRLLKDYDNA---------DAELVIYATSLINKTLAGLNDQDSFYDESDLL 1431
                 :|.|  .:|...:.|:...         |::...:..|::...|...||.::......|:
Mouse   377 -----KGRL--DDIRMEMDDFGEVFQIILNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLI 434

  Fly  1432 EQQGMETVIQRYMSKPGTDLDLLDQLQLYEAVLKFEDGESDGQRLPQNSMRKTQRYRPGANTTER 1496
            |    |.|.|..:.|.|||.|           .|....:.|.:||....:.||:..:..|..||.
Mouse   435 E----ECVSQIVLHKNGTDPD-----------FKCRHLQIDIERLVDQMIDKTKVEKSEAKATEL 484

  Fly  1497 RK------SRRHSTDNSPASLTKVLPTTVLRMTPTQATVDEDSSGSTNSTEFSGGLFNEKKPRDG 1555
            .|      :.||.           |...:.:|                ..:|      |:|.:|.
Mouse   485 EKKLDSELTARHE-----------LQVEMKKM----------------ENDF------EQKLQDL 516

  Fly  1556 AGVTPGLRRRRERAERHKSFLKEQQEAAANGIFAALEQREGLGQIVTAIPATIQTGDSPPQSLQH 1620
            .|....|...:::....|..|:.:.......:....::.|.....:.::.|.:.   :|..|...
Mouse   517 QGEKDALDSEKQQITAQKQDLEAEVSKLTGEVAKLSKELEDAKNEMASLSAVVV---APSVSSSA 578

  Fly  1621 EVPPCNNISGITNISNNNVSNLSCNDTPNNSLLVMSPSKQLLTGSHSISIINNSFDKASNNNQSE 1685
            .|||...:                   |.:|..|:.|.
Mouse   579 AVPPAPPL-------------------PGDSGTVIPPP--------------------------- 597

  Fly  1686 FLTKKNLFRERNSTVINGIMKNIQQTDSAYKKYENEANRLNNYYSQSPKHQIHQPIQPTPEVLLS 1750
                                                                 .|..|.|..::.
Mouse   598 -----------------------------------------------------PPPPPLPGGVVP 609

  Fly  1751 PKKTLNASGFDFTPAPLSSTPVKCDVPPEPEPLSPVKKPAAAPPPPP-------PPPPP------ 1802
            |...|........|.||   |....:||.|:    :...||.|||||       |||||
Mouse   610 PSPPLPPGTCIPPPPPL---PGGACIPPPPQ----LPGSAAIPPPPPLPGVASIPPPPPLPGATA 667

  Fly  1803 -PPPPPGWWHAPIYNSPQARTLTSTNPEL-----LPHPVDPSDMESEDQQLLLQLKRDHTVKDLT 1861
             |||||         .|.| |.....|.|     :|.|..|
Mouse   668 IPPPPP---------LPGA-TAIPPPPPLPGGTGIPPPPPP------------------------ 698

  Fly  1862 QKLSNLPMSPTQDSANRALVGDMSGLISKAKEGLAKSKSKGEISRSSSVDQDVKKSEPKKSENEL 1926
                 ||.|          ||
Mouse   699 -----LPGS----------VG-------------------------------------------- 704

  Fly  1927 HWEELVRNMTRPLNLCDLDFTDLRDDDEKDVLAPRSL--GAGIPPPPPPLGGAIA-PPPMMPPSL 1988
                                          |..|..|  |.|:||||||..||.. |||  ||.:
Mouse   705 ------------------------------VPPPPPLPGGPGLPPPPPPFPGAPGIPPP--PPGM 737

  Fly  1989 A--PPPMYGYGGSLTNSVNSLNGSINGELVNGNNTIKKNKKTVKL-----------------FWK 2034
            .  |||.:|:|....           ..|..|....|..|..|:|                 ||.
Mouse   738 GVPPPPPFGFGVPAA-----------PVLPFGLTPKKVYKPEVQLRRPNWSKFVAEDLSQDCFWT 791

  Fly  2035 EVREDMIPQVVGKTIWDELPDANVDTQKLEHLFESRAKDLMTKKQQE---------LNKSKEIIV 2090
            :|:||..             :.|....||...|.::.|....||.||         ..|.||:.|
Mouse   792 KVKEDRF-------------ENNELFAKLTLAFSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKV 843

  Fly  2091 LDHKRSNAINIAITKLPPP-RAIKTAILKMDATVVTREGIDKLLNMLPTDEERGKIQEAQLSNPE 2154
            ||.|.:..::|.:.....| :.||..||:::..|:|...|..|:..:|..|:...:.|  |....
Mouse   844 LDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQLKMLSE--LKEEY 906

  Fly  2155 LPLGSAEQFLLTLASISELEARLKLWAFRLDFDNSEKEIAEPLMDLKQGIEILRQNRTFRSILST 2219
            ..|..:|||.:.:.::..|..||....|:|.|....:.|...::.:....|.||::..|.|:|..
Mouse   907 DDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSENFSSLLEL 971

  Fly  2220 LLSVGIFLN----GAPVKGFQIEYLAKVPEVKDTVHKHSLLHHLCHMVMESSSDTSDLYSEIGPI 2280
            .|.||.::|    .|...||.|.:|.|:.:.|....|.:|||.|..:......:......|:..:
Mouse   972 TLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSADQKMTLLHFLAELCENDHPEVLKFPDELAHV 1036

  Fly  2281 TRASKADFTDLAHNLNQLE---AECKACWDRLKLIAKHDCPPPLKQKLVDFLADCAERIIILQIV 2342
            .:||:....:|..:|:|::   |:.:.  |.....|..|......:|:..|:.|..|:...|:::
Mouse  1037 EKASRVSAENLQKSLDQMKKQIADVER--DVQNFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMM 1099

  Fly  2343 HRRVMNRYRKFLLWLGMPQHSVAESRPNEFCRTLSEFALEYRTTRERVQQQLEKKANHRERNK-- 2405
            |..:...|::    ||  .:.|.:  |.:.  ::.||.::....|....|.:::....||..:
Mouse  1100 HSNMETLYKE----LG--DYFVFD--PKKL--SVEEFFMDLHNFRNMFLQAVKENQKRRETEEKM 1154

  Fly  2406 TRGKLIIDMAKFKTKDDVADDELKK--LLDTSSADQADGTL-----------TWRRRRAEQ---- 2453
            .|.||    ||.|.:.:..:.:.|:  |:|.::.....|.:           .:||:|..:
Mouse  1155 RRAKL----AKEKAEKERLEKQQKREQLIDMNAEGDETGVMDSLLEALQSGAAFRRKRGPRQVNR 1215

  Fly  2454 ---------LRSPITRQSEEQFTDGDDEILESLVKTATKAPGTRTTPRERK 2495
                     |.|.:|:         ||.:....||...|:.|..|...|.|
Mouse  1216 KAGCAVTSLLASELTK---------DDAMAPGPVKVPKKSEGVPTILEEAK 1257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fhos	NP_001163387.2	FH2	2020..2384	CDD:280362	95/397 (24%)
		CSRNP_N	2357..>2451	CDD:292638	22/108 (20%)
Diaph1	NP_001292909.1	Drf_GBD	84..268	CDD:283920	46/276 (17%)
		Drf_FH3	274..464	CDD:283917	43/230 (19%)
		Spc24	523..>557	CDD:285486	3/33 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	576..746		70/400 (18%)
		FH2	762..1199	CDD:214697	109/467 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1924
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810