Protein Alignment Fhos and diaph2

DIOPT Version :9

• Sequence 1: NP_001163387.2
• Gene: Fhos / 39004
• FlyBaseID: FBgn0266084
• Length: 2528
• Species: Drosophila melanogaster
• Sequence 2: XP_031746616.1
• Gene: diaph2 / 100485481
• XenbaseID: XB-GENE-6258603
• Length: 1100
• Species: Xenopus tropicalis
• Alignment Length: 1246
• Identity: 257/1246 - (20%)
• Similarity: 416/1246 - (33%)
• Gaps: 402/1246 - (32%)

  Fly  1489 PGAN--TTERRKSRRHSTD-----NSPA--------------SLTKVLPTTVLRMTP-------T 1525
            ||.|  .|..:.|:|.:.|     |.|.              .||....:.|.:..|       :
 Frog    15 PGKNAEVTSSKNSKRKAIDPDEGKNKPKLNIHIKTLADDVRDRLTSFRKSAVKKEKPLIQHPTDS 79

  Fly  1526 QATVDE--------DSSGSTNSTEFSGGLFNEKKPRDGAGVTPGLRRRRERAERHKSFLKEQQEA 1582
            ||.|.:        |......|.:....|| ||...|     ..|...|:...|.|...::.:
 Frog    80 QAVVTDFPAPQQLFDERSLNLSEKEIMDLF-EKMMED-----MNLNEERKAPLRQKDLTRKHE-- 136

  Fly  1583 AANGIFAALEQREGLGQIVTAIPATIQTGDSPPQSLQHEVPPCNNISGITNISNNNVSNLSCNDT 1647
                            .:|..|.||.::|..  ::.:||   |      |..|...|..|....|
 Frog   137 ----------------MVVQYISATAKSGGL--KNSKHE---C------TLSSQEYVHELRSGIT 174

  Fly  1648 PNNSLLVMSPSKQLLTGSHSISIINN-----------SFDKASNNNQSEFLTKKNLFRERNSTVI 1701
            ....|..:...:..|| |:.:|.:||           ..:|..:..|.|.:.|||..
 Frog   175 DEKLLNCLESLRVSLT-SNPVSWVNNFGHEGLGLLLDVLEKLLDKKQQESIDKKNQH-------- 230

  Fly  1702 NGIMKNIQQTDSAYKKYENEANRLNNYYSQ-----------SPKH-------------------- 1735
                |.||    ..|.:.|....|....|:           .||.
 Frog   231 ----KLIQ----CLKAFMNNKYGLQRILSEDRSLLLLARAIDPKQANMMTEILKILSAICIIGED 287

  Fly  1736 --------------QIH--QPIQPTPEVLLSPKK-TLNASGFDFTPAPLSSTPVKCDVPPEPEPL 1783
                          :||  :...|..|.|.:.:. .|.||...|..|.|:|          ||.|
 Frog   288 NILDKLLEAITTAAEIHNKERFAPIVEALENHEAFQLQASCMQFINALLTS----------PEEL 342

  Fly  1784 SPVKKPAAAPPPPPPPPPPPPPPPGWWHAPIYNSPQARTLTSTNPELLPHPVDPSDMESEDQQLL 1848
            .                         :...:.|......|....|||         .|.|:::|.
 Frog   343 D-------------------------FRIHLRNEFLRCGLKQILPEL---------KEKENEELD 373

  Fly  1849 LQLK------------RDHTVKDLTQKLS------NLPMSPTQDSANRA---------------- 1879
            :|||            ..|.::|:..::.      :|..:..:|:|:..
 Frog   374 IQLKVFDENKEEDLLELSHRLRDIRAEMDDINEVYHLLYNMLKDTASETYFQSILQHFLLIRNDY 438

  Fly  1880 --------LVGDMSGLISKAKEGL---AKSKSKGEISRSSSVD-----QDVKKSEPKKSENELHW 1928
                    ::.:..|.:.....|:   .:.:.:.:|..|..:|     ..|::||.|.||....:
 Frog   439 YIRPQYYKVIDECVGQVVLQCSGMDPDFRYRGRLDIDFSHLIDACVDKAKVEESEKKASEFSKKF 503

  Fly  1929 EE----------LVRNMTRPLNLCDLDFTDLRDDDEK---DVLAPRSLGAGIPPPPPPLGGAIAP 1980
            :|          .::.:...:...:.:...|:....|   ...|..||....|||||||.|.|||
 Frog   504 DEEFTARQEAQAELQKLEEKIKALETENQQLKTQGPKLPTQAEAGSSLPPPPPPPPPPLFGNIAP 568

  Fly  1981 PP-----------------MMPPSLAPPPMYG------YGGSLTNSVNSLNGSINGELVNGNNTI 2022
            ||                 :.|||..|||::|      :||                       |
 Frog   569 PPPPPPLPGGIPPPPPPLGLCPPSAPPPPLFGAPPPPPFGG-----------------------I 610

  Fly  2023 K------------KNKKTVK-------LFWKEVREDMIPQVVGKT-IW-----DELPDANVDTQK 2062
            :            |.||..|       :.|.:|.    ||.:.:| ||     |...:..:.| :
 Frog   611 RPPPPPVQLPFGMKPKKIYKPETNMKRINWSKVE----PQDITETCIWVKAKEDHFENPEIFT-R 670

  Fly  2063 LEHLFESRAKDLMTKKQQELNKS-------KEIIVLDHKRSNAINIAITKLPPP-RAIKTAILKM 2119
            |..:|.:..|.....:|.|.||.       ||:.|||.|.:..::|.:...... ..||:.||::
 Frog   671 LSQMFATHMKAKKATEQAEENKPTLIKKKVKELRVLDSKTAQNLSIFLGSYRMSYEEIKSMILEV 735

  Fly  2120 DATVVTREGIDKLLNMLPTDEERGKIQEAQLSNPELPLGSAEQFLLTLASISELEARLKLWAFRL 2184
            |...::...|..|:..||..:|...:  :||.:....|...|||.:.:::|..|.:||....|:|
 Frog   736 DEEKLSESLIQNLIKNLPEQKELSAL--SQLKSEYEDLCEPEQFGVVMSTIKMLRSRLNGILFKL 798

  Fly  2185 DFDNSEKEIAEPLMDLKQGIEILRQNRTFRSILSTLLSVGIFLN----GAPVKGFQIEYLAKVPE 2245
            .||.....|...::.:....|.|:::.:|:.|:..:|.||.::|    .|...||.:.:|.|:.:
 Frog   799 TFDEHISNIKPDIIAVTLACEELKKSESFKKIVELVLLVGNYMNSGSRNAQSLGFNVSFLCKIRD 863

  Fly  2246 VKDTVHKHSLLHHLCHMVMESSSDTSDLYSEIGPITRASKADFTDLAHNLNQLEAECKACWDRLK 2310
            .|.:..|.:|||.|..:..|...:......|:..:..|||....:|..:|:.:|.:.|.....:|
 Frog   864 TKSSDQKTTLLHFLAEICEERFKEILKFPDELEHVESASKVSAQNLKSSLDAMEHQIKRLEGDIK 928

  Fly  2311 LIAKHDCPPPLKQKLVD------FLADCAERIIILQIVHRRVMNRYRKFLLWLGMPQHSVAESRP 2369
            ...|.|.|   ..|.|:      |.....|:...|..::..:...|.....:|.....:|:   .
 Frog   929 NFTKTDNP---NDKFVEKMTTYIFAKGAREQYEKLSNMYNHMNKLYDNLGDYLTFDAKAVS---V 987

  Fly  2370 NEFCRTLSEFALEYRTTRERVQQQLEKKANHRERNKTRGKLIIDMAKFKTKDDVADDELKK--LL 2432
            .||...||.|    ||......::..|:....|:.| |.|:    ||.|.:.:..:.:.||  |:
 Frog   988 EEFFGDLSSF----RTLFLEAVKENNKRREMEEKMK-RAKI----AKEKAEREKLERQHKKKQLI 1043

  Fly  2433 DTSSADQADGTLTWRRRRAEQLRSPITRQSEEQFTDGDDEILESLVKTATKAPGTRTTPR----- 2492
            |.:......|.:                          |.:||:|...|......:.||:
 Frog  1044 DINKEGDETGVM--------------------------DSLLEALQSGAAFRDRRKRTPKTNDNR 1082

  Fly  2493 ----ERKRTRH 2499
                ||.|:||
 Frog  1083 QVALERSRSRH 1093

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fhos	NP_001163387.2	FH2	2020..2384	CDD:280362	98/406 (24%)
		CSRNP_N	2357..>2451	CDD:292638	22/95 (23%)
diaph2	XP_031746616.1	Drf_GBD	100..283	CDD:399398	45/234 (19%)
		Drf_FH3	291..479	CDD:368862	35/231 (15%)
		FH2	625..1001	CDD:396655	98/392 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910