Protein Alignment Fhos and Fhod3

DIOPT Version :10

• Sequence 1: NP_001163387.2
• Gene: Fhos / 39004
• FlyBaseID: FBgn0266084
• Length: 2528
• Species: Drosophila melanogaster
• Sequence 2: NP_001402649.1
• Gene: Fhod3 / 100360334
• RGDID: 2322319
• Length: 1586
• Species: Rattus norvegicus
• Alignment Length: 1600
• Identity: 617/1600 - (38%)
• Similarity: 834/1600 - (52%)
• Gaps: 292/1600 - (18%)

  Fly  1175 VEWLD-----NGSNFYEPPE-------------------QRQHQPPRRIDDAAIQVYKDGDYGAY 1215
            |::||     |.:||.||..                   .|..:.|.::||..:|:..:   |||
  Rat     8 VQFLDDTDPFNSTNFPEPSRPPLFTFREDLALGTQLAGVHRLLRAPHKLDDCTLQLSHN---GAY 69

  Fly  1216 LDLESSLAEQAEEIEG----VNVSRKNSLVVRTQLNVRVQAIIEKLLSAQGSDLRRALFSLKQVF 1276
            ||||::||||.:|:||    ....:|||:::||||:|||.|.||||.::.|.|||||||||||:|
  Rat    70 LDLEATLAEQRDELEGFQDDTGRGKKNSIILRTQLSVRVHACIEKLYNSTGRDLRRALFSLKQIF 134

  Fly  1277 QEDKDLVHAFVALGGLNCLVRVGNCADQNYQNYILRALGQVMLYVDGMNGVMKHEPTMQWLYSLI 1341
            |:||||||.||...||.||::||..|||||||||||||||:||||||||||:.|..|:||||:|:
  Rat   135 QDDKDLVHEFVIAEGLTCLIKVGAEADQNYQNYILRALGQIMLYVDGMNGVINHSETIQWLYTLV 199

  Fly  1342 ASNYRSVVKTALKLLLVFVEYAESNCYVLVSAIHAVDASQGTLPWSNIMRLLKDYDNADAELVIY 1406
            .|.:|.|||||||||||||||:|||..:|:.|:.|||..:|..||||||.:|::.|..|.||::|
  Rat   200 GSKFRLVVKTALKLLLVFVEYSESNAPLLIQAVSAVDTKRGVKPWSNIMEILEEKDGVDTELLVY 264

  Fly  1407 ATSLINKTLAGLNDQDSFYDESDLLEQQGMETVIQRYMSKPGTDLDLLDQLQLYEAVLKFEDGES 1471
            |.:|:|||||||.|||:|||..|.||:.|:..|.||:::|.|||||||:|..:||..|:.|||:.
  Rat   265 AMTLVNKTLAGLPDQDTFYDVVDCLEELGIAAVSQRHLNKKGTDLDLLEQFNIYEVALRHEDGDE 329

  Fly  1472 DGQRLPQNSMRKTQRYRPGANTT------ERRKSRRHSTDN--SPASL-TKVLPTTVLRMTPTQA 1527
            ..:..|.....:.:.......|.      :||:|||||..|  ||.|. |.....||....|:|.
  Rat   330 TAEPPPSGHRDRRRASMCSGGTVGEQQGLDRRRSRRHSIQNIKSPLSAPTSPCSQTVPAFKPSQV 394

  Fly  1528 -----TVDEDSSGSTNSTEFSGGLFNEKKPRDGAGVTPGLRRRRERAERHKSFLKEQQEAAANGI 1587
                 ..:|:.......||     .|.::.|:......|...:...|.:...  .|:.....:..
  Rat   395 RDLCEKDEEEEEEEQPITE-----PNSEEEREDDAQCQGKDSKASSASKQSP--PEKDATPESST 452

  Fly  1588 FAALEQREGLGQIVTAIPAT---IQTGDSPPQSLQ--HEVPPCNNI------------------- 1628
            ..........|:.:.|.||.   :..|.|.|::.:  ..:||.:.:
  Rat   453 LRTTSSPTSQGRWLPANPAAQSPVLAGTSGPEASRPAARLPPPSPVLAPRPSTAPKVSPTIDKLP 517

  Fly  1629 -----------------------SGITNISNNNVSNLSCNDTPNNSLLVMSPSKQLLTGSHSISI 1670
                                   .|..:.:.|..||.|     ::|.....||........|.|.
  Rat   518 YVPHSPFHLFSYDFEDSPLLTKDKGGDSQTENRYSNFS-----SSSFQSSRPSPGPSVSPSSASS 577

  Fly  1671 INNSFDKASNNNQSEFLTKKNLFRERNSTVINGIMKNIQQTDSAYKKYE-NEANRLNNYYSQSPK 1734
            .::..|  :.::.|..||..  ||:...::.....:..|:.:...::.| .|.|:.|..|....:
  Rat   578 FSSPQD--TRSSPSGLLTSS--FRQHQESLAAERERRRQEREERLQRIEREERNKFNREYLDKRE 638

  Fly  1735 HQ-----------------IHQPIQPTPEVL-----LSPKKTLNASGFDFTPAPLSSTPVKCD-- 1775
            .|                 .|:..|.:....     ||...:|.|:  ..:|:|.|.:|...|
  Rat   639 EQRQARGERYKYLEHLAAEAHEKEQRSRSASRGRADLSLDLSLPAA--PASPSPSSPSPDSADSQ 701

  Fly  1776 -------VPP------------EPE--------------PLSPVKKPAAAPPPPPPPPPPP---- 1803
                   .||            |||              .::...:.|.:...|.....|.
  Rat   702 EALTVPSTPPTLQYPQVSGKDREPELEAEAGQGADEASRDIASAHREAGSQEEPALELEPEERAS 766

  Fly  1804 ----------------------------------------PPPPGWWHAPI----YNSPQARTLT 1824
                                                    ..|.|.|.|.:    .|......||
  Rat   767 LSEKERQNEEVNERDNCSASSISSSSSTLEREEKEDKLSGDRPTGLWSASLQDVGVNGQCGDILT 831

  Fly  1825 STN---PELLPH-PVDPSDMESEDQQLLLQLKRDHTVKDLTQKLSNLPMS--PTQDSANRALVG- 1882
            |..   ..|..| .....|.|..|.:.....:....|..|..::|.|..:  ..::|..|..:|
  Rat   832 SKRFMLDMLYAHNRKSTEDEEKGDGEPGRSAQEVEAVASLATRISTLQANSQAPEESIKRVDIGC 896

  Fly  1883 -DMSGLISKAKEGLAKSKSKGEISRSS-SVDQDVKKSEPK------KSENELHWEELVRNMTRPL 1939
             |..|.:    :..|:..:.||:.|.| |.|.:.:...|.      |:|::..|::|:.| .|.|
  Rat   897 LDNRGSV----KAFAEKFNSGEVGRGSVSPDAESQDKVPDTPPAQLKTESDYIWDQLMAN-PREL 956

  Fly  1940 NLCDLDFTDLRDDDEKDVL--------APRSLGAGIPPPPPP--LGGAIAPPPMMPPSLAPPPMY 1994
            .:.|:|||||.::|:.|||        ||     |.||||||  ||....|||.:..|:.|||:.
  Rat   957 RIQDMDFTDLGEEDDIDVLDVDLGHREAP-----GPPPPPPPTFLGLPPPPPPPLLDSVPPPPVP 1016

  Fly  1995 G--YGGSLTNSVNSLNGSINGELVNGNNTIKKNKKTVKLFWKEVREDMIPQVVGKT----IWDEL 2053
            |  ....:.|:...|..|   ::..|.....|.|||::|||.|||....|....:.    :|.:|
  Rat  1017 GNLLASPVFNTPQGLGWS---QVPKGQPAFTKKKKTIRLFWNEVRPFEWPSKNNRRCREFLWSKL 1078

  Fly  2054 PDANVDTQKLEHLFESRAKDL-MTKKQQELNKSKEIIVLDHKRSNAINIAITKLPPPRAIKTAIL 2117
            ....|||.:|||||||::|:| :|||.....|.:||||||.||||||||.:|.|||||.||.|||
  Rat  1079 EPIKVDTSRLEHLFESKSKELSVTKKTAADGKRQEIIVLDSKRSNAINIGLTVLPPPRTIKIAIL 1143

  Fly  2118 KMDATVVTREGIDKLLNMLPTDEERGKIQEAQLSNPELPLGSAEQFLLTLASISELEARLKLWAF 2182
            ..|...:.:|||:|:|.|:||:||:.|||||||:|||:||||||||||||:|||||.|||.||||
  Rat  1144 NFDEYALNKEGIEKILTMIPTEEEKQKIQEAQLANPEVPLGSAEQFLLTLSSISELSARLHLWAF 1208

  Fly  2183 RLDFDNSEKEIAEPLMDLKQGIEILRQNRTFRSILSTLLSVGIFLNGAPVKGFQIEYLAKVPEVK 2247
            ::|::.:|||:||||:|||:||:.|..|:|...||||||::|.||||...|.|::.||.||||||
  Rat  1209 KMDYETTEKEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLNGTNAKAFELSYLEKVPEVK 1273

  Fly  2248 DTVHKHSLLHHLCHMVMESSSDTSDLYSEIGPITRASKADFTDLAHNLNQLEAECKACWDRLKLI 2312
            |||||.|||||:|.||:|:..|:||||||||.|||::|.||..|..||.|:|..|||.||.||.|
  Rat  1274 DTVHKQSLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFDQLQDNLCQMERRCKASWDHLKAI 1338

  Fly  2313 AKHDCPPPLKQKLVDFLADCAERIIILQIVHRRVMNRYRKFLLWLGMPQHSVAESRPNEFCRTLS 2377
            |||:..|.|||::.:.|.|||||||||:|||||::||:..|||::|.|.:::.|...|:|||.:|
  Rat  1339 AKHEMKPVLKQRMSELLKDCAERIIILKIVHRRIINRFHSFLLFMGHPPYAIREVNINKFCRIIS 1403

  Fly  2378 EFALEYRTTRERVQQQLEKKANHRERNKTRGKLIID--------MAKFKTK-------------- 2420
            |||||||||||||.||.:|:||||||||||||:|.|        ..||...
  Rat  1404 EFALEYRTTRERVLQQKQKRANHRERNKTRGKMITDTDDEDDTESGKFSGSSPAAPSQPQGLSYA 1468

  Fly  2421 DDVADDE-LKKLLDTSSADQADGT----LTWRRRRAEQLRSPITRQSEEQFT---DGDDEILESL 2477
            :|.|:.| :|.:|.|||....|.|    :..|.|.:....|..|..:||..:   |..|||::.:
  Rat  1469 EDAAEHENMKAVLKTSSPALEDATPMLGVRTRSRASRGSTSSWTMGTEESPSVPDDAADEIMDRI 1533

  Fly  2478 VKTATKAPGTRTTPRERKRTRHADRKSLRRTLKNGLTEEE 2517
            ||:||:.|..|..||||||:| |:|||||||||:|||.||
  Rat  1534 VKSATQVPSQRVVPRERKRSR-ANRKSLRRTLKSGLTPEE 1572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fhos	NP_001163387.2	Formin_GBD_N	1174..1265	CDD:465735	43/117 (37%)
		FH2	2020..2384	CDD:396655	218/368 (59%)
Fhod3	NP_001402649.1	Formin_GBD_N	6..123	CDD:465735	43/117 (37%)
		PHA03247	441..>517	CDD:223021	10/77 (13%)
		FH2	1039..1410	CDD:396655	219/370 (59%)