Protein Alignment Prm and MYO1

DIOPT Version :10

• Sequence 1: NP_523982.2
• Gene: Prm / 39002
• FlyBaseID: FBgn0003149
• Length: 879
• Species: Drosophila melanogaster
• Sequence 2: NP_011888.1
• Gene: MYO1 / 856418
• SGDID: S000001065
• Length: 1928
• Species: Saccharomyces cerevisiae
• Alignment Length: 1086
• Identity: 226/1086 - (20%)
• Similarity: 426/1086 - (39%)
• Gaps: 314/1086 - (28%)

  Fly    28 IEYIQDL------------SSLSRLEDKIRLLQ---DDLEVERELRQRIEREKADLSVQVIQMSE 77
            :|..|||            |.|:|::.....||   |||..|::   .|.|||       :::::
Yeast   898 LENTQDLLNQEKENLRKNESLLNRVKTSSETLQKQFDDLVSEKD---EISREK-------LEVAQ 952

  Fly    78 RLEEAEGGAEHQFEANRKRDAELLKL----RKLLE-------DVHLESEETTLLLKKK---HNEI 128
            .||||....:...|..|:|:|.|.||    .:|::       |:..|....:|:.:.|   .|||
Yeast   953 NLEEAHQKIQGLQETIREREATLEKLHSKNNELIKQISDLNCDISKEQSSQSLIKESKLKLENEI 1017

  Fly   129 ------ITDFQEQVEILTKNKARAEKD---------------KAKFQ---TEVYELLSQIESYNK 169
                  |...:|:::......:.:|:|               .::.|   ||..:|.|:.|::.|
Yeast  1018 KRLKDVINSKEEEIKSFNDKLSSSEEDLDIKLVTLEKNCNIAMSRLQSLVTENSDLRSKNENFKK 1082

  Fly   170 EKIVSEKHISKLEVSISELNVKIEELNRTVIDISSHRSRLSQENIELTKDVQDLKVQLDTVSFSK 234
            ||......:...|..:.::..||:...:.:...|..|.....|:.::|.::::.::||.....:.
Yeast  1083 EKAALNNQLKNKESELLKMKEKIDNHKKELATFSKQRDDAVSEHGKITAELKETRIQLTEYKSNY 1147

  Fly   235 SQVISQLEDARRRL-EDEDRRRSLLESSLHQVEIELDSVRNQLEEESEARIDLERQL-------- 290
            .::..:..:.:|.. |.|.::|:.|..||:      ||...:||......|.|.:.|
Yeast  1148 QKIKEEYSNFQRETKEQEQKKRNSLVESLN------DSKIKELEARLSQEISLNQYLNKRISGNS 1206

  Fly   291 VKANADATSWQNKWNSEVAARAEEVEEIRRKY---QVRITELEEHIESLIVK----VNNLEKMKT 348
            |:.|..:|.....::.:..    :.|:|.:||   |:..||:..::|:.|.:    ::.|...:|
Yeast  1207 VETNISSTRRSTSYSDDPL----DKEDIIKKYYDLQLAFTEITRNLENEIEEKKNLISRLRFTET 1267

  Fly   349 RLAS-------------EVEVLIIDLEKS----------NNSCRELTKSVNTLEKHNVELKSRLD 390
            ||||             :::.||.|::.|          .::|.:....:|.|......||.:||
Yeast  1268 RLASSSFEDQKIKAQMKKLKKLIQDMDPSIPLDSILNEPLDNCPDKESDINKLMLEVDYLKRQLD 1332

  Fly   391 -ET--------------------------------IILYETSQRDLKNKH--------------- 407
             ||                                .:.:|.|:..:|:..
Yeast  1333 IETRAHYDAENAISALHSKFRKIQGESSLSSSDIYKLKFEASEERVKSLEDKLKTMPLRDRTNLP 1397

  Fly   408 -ADLVRTVHELDKVKDNNNQLTRENKKLGDDLHEAKGAINE--------------LNRRLHELEL 457
             .|:::....:.|.::.......||.||.:.|:|:.|.:::              |:.:|..|:.
Yeast  1398 VGDIIKNRDSISKYEEEIRYYKLENYKLQEILNESNGKLSQLTLDLRQSKSKEALLSEQLDRLQK 1462

  Fly   458 ELRRLENERDELTAAYKEAE----------------------AGRKAEE---------------- 484
            :|...|.:::.|::..|:.:                      |.::|||
Yeast  1463 DLESTERQKELLSSTIKQQKQQFENCMDDLQGNELRLREHIHALKQAEEDVKNMASIIEKLKTQN 1527

  Fly   485 QRGQRLAADFNQYRHDAERRLAEK---------------------DEEIEAI--RKQTSIEI--- 523
            ::.::|..:....|:|::.:|.|.                     .|.:.|:  |.|.:.||
Yeast  1528 KQKEKLIWEREMERNDSDMQLQETLLELKRVQDVKKILSDDLAHLKERLSAVEDRSQYTDEINRL 1592

  Fly   524 -EQLNARVIEAETRLKTEVTRIKKKLQIQITELEMSLDVANKTNIDLQKVIKKQSLQLTELQAHY 587
             |:||.. ::|||.||.|...:|.||:....:.|..:.       ||.|.:.           ||
Yeast  1593 KEELNCS-LKAETNLKKEFATLKYKLETSTNDSEAKIS-------DLLKQLD-----------HY 1638

  Fly   588 EDVQRQLQATLDQYAVAQRRL----AGLNGELEEVRSHLDSANRAKRTVELQYEEAASRINELTT 648
            ..|...|....|..::|::.|    ..||.|.|.::..:.|..:.|:.:|       |.:|:.|.
Yeast  1639 TKVVEMLNNEKDAISLAEKELYQKYEALNTECESLKGKIVSLTKIKQELE-------SDLNQKTD 1696

  Fly   649 A----NVSLVSIKSK----------LEQELSVVA---SDYEEVSKELRISDERYQKVQVELKHVV 696
            |    |.:|.|...|          ||:.|.:..   |...|:.|.|:.|...|:....:.|...
Yeast  1697 ALQISNAALSSSTQKNKEITEKIKYLEETLQLQMEQNSRNGELVKTLQASCNGYKDKFDDEKQKN 1761

  Fly   697 EQVHEEQERIVKLETIKKSLEVEVKNLSIRLEE-VELNAVAGSKRIISKLEARIRDLELELEEEK 760
            ..::||.:.:.||.|   .|::::|||..||.: .|.||....   |.:||..: .||.:|:.|:
Yeast  1762 IDLYEENQTLQKLNT---DLQLQLKNLHERLSDTTEKNAWLSK---IHELENMV-SLETDLKYEE 1819

  Fly   761 RRHAETIKILRKKERTVKEVLVQCEEDQKNLILL----QDALDKSTAKINIYRRQLSEQEGVSQQ 821
            .:..:::      ||.|:|:..: ...|.::|.|    :...:::|.|   |..|:|:.|....|
Yeast  1820 MKKNKSL------ERAVEELQTK-NSQQTDVIELANKNRSEFEEATLK---YEAQISDLEKYISQ 1874

  Fly   822 TTTRVRRFQRELEAAEDRADTAESSLNIIRAKHRTFVTTSTVPGSQ 867
            ....:::..|:..:..|:.......:...::::.     ||:.||:
Yeast  1875 QELEMKKSIRDNSSYRDKVQEMAQEIEFWKSRYE-----STMIGSK 1915

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prm	NP_523982.2	Myosin_tail_1	<34..853	CDD:460256	219/1064 (21%)
MYO1	NP_011888.1	COG5022	2..1691	CDD:227355	168/838 (20%)
		Smc	1607..>1901	CDD:440809	78/335 (23%)